Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 10/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809278 | 0.84 | FDPS (0.46) | ALDH1A1L3MBTL1CYP1A2CYP2C19FDPS | |
| SCHEMBL2808779 | 0.82 | ALDH1A1 (0.52) | ALDH1A1CYP1A2CYP2C19FDPSMAPT | |
| SCHEMBL2810172 | 0.82 | FDPS (0.45) | ALDH1A1L3MBTL1CYP1A2CYP2C19FDPS | |
| SCHEMBL524215 | 0.81 | KMT2A (0.55) | ALDH1A1L3MBTL1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL20482174 | 0.79 | LMNA (0.59) | ALDH1A1L3MBTL1CYP1A2CYP2C19FDPS | |
| SCHEMBL7951853 | 0.78 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL27339812 | 0.78 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1CYP1A2CYP2C19FDPS | |
| SCHEMBL2391793 | 0.77 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL4007449 | 0.77 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL22301646 | 0.76 | FDPS (0.51) | ALDH1A1L3MBTL1FDPSMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |
| US-8975252-B2 | Morpholine derivative | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2015-03-10 | — | — | US | disclosed |
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2010-09-23 | — | — | US | disclosed |
| EP-2168952-A1 | MORPHOLINE DERIVATIVE | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | REN, AGTR1, AGTR2 | ALDH1A1 2202/4885L3MBTL1 4737/4885CYP1A2 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.