Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Saccharin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 5/20 | 0.41 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.41 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.41 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Saccharin SCHEMBL3372 | 1.00 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL787894 | 1.00 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL485938 | 0.98 | GPR3 (0.43) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL1138065 | 0.98 | GPR3 (0.43) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL29364573 | 0.98 | GPR3 (0.43) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL10399957 | 0.96 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL473608 | 0.96 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL2954783 | 0.96 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL8668442 | 0.96 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL5870938 | 0.96 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6090 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743098-A1 | THERAPEUTIC USE OF FIBROBLASTS FOR THE TREATMENT OF PSORIASIS | FibroBiologics, Inc. (US) | 2026-05-20 | — | — | EP | claimed |
| EP-3834815-B1 | TOPICAL AQUEOUS PHARMACEUTICAL COMPOSITIONS OF FLURBIPROFEN AND CHLORHEXIDINE | SANOVEL ILAC SANAYI VE TICARET AS (TR) | 2026-05-06 | — | — | EP | claimed |
| WO-2026090082-A2 | METHODS FOR PREVENTION OF INSTANT BLOOD-MEDIATED INFLAMMATORY REACTION IN CELL BASED THERAPEUTICS | FIBROBIOLOGICS, INC. (US) | 2026-04-30 | — | — | WO | claimed |
| EP-4659739-A9 | TOPICAL FORMULATION COMPRISING NON-COVALENT KERATIN-ACTIVE AGENT CONJUGATES FOR THERAPEUTIC USE | Rigi Therapeutics AG (CH) | 2026-04-29 | — | — | EP | claimed |
| EP-4698146-A1 | LIQUID AND SOLID COMPOSITIONS OF IMIPRIDONE DERIVATIVES | Institut Gustave-Roussy (FR) | 2026-02-25 | — | — | EP | claimed |
| US-20250387310-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2025-12-25 | — | — | US | claimed |
| EP-4659739-A1 | TOPICAL FORMULATION COMPRISING NON-COVALENT KERATIN-ACTIVE AGENT CONJUGATES FOR THERAPEUTIC USE | Rigi Therapeutics AG (CH) | 2025-12-10 | — | — | EP | claimed |
| EP-4659738-A1 | TOPICAL FORMULATION CONTAINING KERATIN PARTICLES FOR DERMATOLOGICAL USE | Rigi Therapeutics AG (CH) | 2025-12-10 | — | — | EP | claimed |
| EP-3523274-B1 | FORMULATIONS FOR ADMINISTRATION OF EFLORNITHINE | ORBUS THERAPEUTICS INC (US) | 2025-11-05 | — | — | EP | claimed |
| US-12403103-B2 | Compositions and methods useful for treatment of respiratory illness | THE PROCTER & GAMBLE COMPANY (US) | 2025-09-02 | — | — | US | claimed |
| US-11419851-B2 | Oral formulations of pyrrolidine derivatives | ObsEva S.A. (CH) | 2022-08-23 | — | — | US | claimed |
| EP-4039338-A1 | ORAL-HEALTH COMPOSITION AND PREPARATION METHOD FOR ORAL-HEALTH COMPOSITION | MMF&T Desenvolvimento Tecnológico e Inovação Ltda. (BR) | 2022-08-10 | — | — | EP | claimed |
| EP-4039245-A1 | FLAVOUR AND FRAGRANCE COMPOSITIONS COMPRISING ACETOPHENONE DERIVATIVES | Symrise AG (DE) | 2022-08-10 | — | — | EP | claimed |
| WO-2022155054-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2022-07-21 | — | — | WO | claimed |
| EP-4025207-A1 | OXYTOCIN ANTAGONIST DOSING REGIMENS FOR PROMOTING EMBRYO IMPLANTATION AND PREVENTING MISCARRIAGE | ObsEva S.A. (CH) | 2022-07-13 | — | — | EP | claimed |
| US-20220204517-A1 | INHALED POWDER FORMULATIONS | GENENTECH, INC. (US) | 2022-06-30 | — | — | US | claimed |
| US-20220152016-A1 | Compositions And Kits Useful For Treatment Of Respiratory Illness | PROCTER & GAMBLE (US) | 2022-05-19 | — | — | US | claimed |
| US-11319279-B2 | Antimicrobial compound and use thereof | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2022-05-03 | — | — | US | claimed |
| US-11285091-B2 | M-aminophenol-free hair-colouring compositions | BEAUTY & BUSINESS S.P.A. (IT) | 2022-03-29 | — | — | US | claimed |
| US-20220023236-A1 | Compositions And Kits Useful For Treatment Of Respiratory Illness | PROCTER & GAMBLE (US) | 2022-01-27 | — | — | US | claimed |