Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Saccharin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 5/20 | 0.41 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.41 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.41 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Saccharin SCHEMBL787894 | 1.00 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL29355014 | 1.00 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL485938 | 0.98 | GPR3 (0.43) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL1138065 | 0.98 | GPR3 (0.43) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL29364573 | 0.98 | GPR3 (0.43) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL10399957 | 0.96 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL473608 | 0.96 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL2954783 | 0.96 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL8668442 | 0.96 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 | |
| Saccharin SCHEMBL5870938 | 0.96 | GPR3 (0.44) | GPR3CA9CA12KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 96867 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144747-A1 | SYRUP PREPARATION | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2026-05-28 | — | — | US | claimed |
| CN-122081908-A | Alkaline chemical nickel surface treatment method for pure aluminum or aluminum alloy | — | 2026-05-26 | — | — | CN | claimed |
| CN-122082054-A | Electrolysis additive composition and application method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122074696-A | Buccal product and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075589-A | Preparation method of pelvic inflammation eliminating oral liquid | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075376-A | An oral cavity cough liquid for preventing and treating stomatocace and refreshing breath, and its preparation method | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075328-A | Dentifrice with whitening, tooth stain removing and anti-inflammatory effects and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121802410-B | Electroplating Ni-P-Fe on surface of aluminum nitride substrate2O3Method for producing a PTFE composite lubricant layer | 深圳市好利时实业有限公司 | 2026-05-22 | — | — | CN | claimed |
| WO-2026103205-A1 | ORALLY DISINTEGRATING TABLET OF PIMAVANSERIN OR SALT THEREOF AND PREPARATION METHOD THEREFOR | 江苏百奥信康医药科技有限公司 | 2026-05-21 | — | — | WO | claimed |
| EP-4746079-A1 | SECONDARY BATTERY AND PREPARATION METHOD THEREFOR, AND ELECTRIC DEVICE | Contemporary Amperex Technology Co., Limited (CN) | 2026-05-20 | — | — | EP | claimed |
| US-4140772-A | SACCHARIN OR ALKALI METAL SALT THEREOF | DART INDUSTRIES INC. (US) | 1979-02-20 | — | — | US | claimed |
| US-4127645-A | CANDY, LEAVENING AGENT AND AN ACIDULANT | LIFE SAVERS, INC. (US) | 1978-11-28 | — | — | US | claimed |
| US-4088788-A | ORGANIC CARBOXYLIC ACID AND SACCHARIN | WM. WRIGLEY JR. COMPANY (US) | 1978-05-09 | — | — | US | claimed |
| US-4087557-A | ROSIN AND DERIVATIVES, SACCHARIN | LIFE SAVERS, INC. (US) | 1978-05-02 | — | — | US | claimed |
| US-4085227-A | FINELY DIVIDED POORLY WATER-SOLUBLE SWEETENING AGENTS AND/OR FOOD ACIDS | LIFE SAVERS, INC. (US) | 1978-04-18 | — | — | US | claimed |
| US-4064274-A | Long-lasting flavored chewing gum including chalk-free gum base | LIFE SAVERS, INC. (US) | 1977-12-20 | — | — | US | claimed |
| US-4053586-A | PREPARATION FOR TREATING SQUAMOUS CELL CARCINOMA AND METHOD FOR MAKING SAME | INTERMOUNTAIN LABORATORIES, INC. (US) | 1977-10-11 | — | — | US | claimed |
| US-4041042-A | Intermediate composition | WARNER-LAMBERT COMPANY (US) | 1977-08-09 | — | — | US | claimed |
| US-4010285-A | SACCHARIN | Van Doren, Fred M. (US) | 1977-03-01 | — | — | US | claimed |
| US-3982010-A | Thiazole cardiovascular agents | SYNTEX (U.S.A.) INC. (US) | 1976-09-21 | — | — | US | claimed |