Ipriflavone

Ipriflavone

SCHEMBL29485035

CC(C)Oc1ccc2c(=O)c(-c3ccccc3)coc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 1.00
MAPT P10636 8/20 1.00
SMN1; SMN2 Q16637 7/20 1.00
NPC1 O15118 6/20 1.00
RAB9A P51151 6/20 1.00
MEN1 O00255 6/20 1.00
KMT2A Q03164 6/20 1.00
MAPK1 P28482 3/20 1.00
GAA P10253 2/20 1.00
POLB P06746 2/20 1.00
HDAC6 Q9UBN7 2/20 1.00
PTGS1 P23219 1/20 1.00
SLC6A2 P23975 1/20 1.00
STAT1 P42224 1/20 1.00
CASP3 P42574 1/20 1.00
HTT P42858 1/20 1.00
HIF1A Q16665 1/20 1.00
SENP8 Q96LD8 1/20 1.00
SENP7 Q9BQF6 1/20 1.00
SENP6 Q9GZR1 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ipriflavone SCHEMBL111472 1.00 ALDH1A1 (1.00) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL8635594 0.89 ALDH2 (0.83) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL738941 0.88 ALDH2 (0.80) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL11557001 0.88 ALDH1A1 (0.78) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL1701110 0.87 ALDH2 (1.00) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL28048765 0.87 ALDH1A1 (0.77) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL11012140 0.87 ALDH2 (0.77) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL2070406 0.86 NPC1 (1.00) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL762092 0.85 MAPT (1.00) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A
SCHEMBL11012372 0.85 MAPT (0.73) ALDH1A1MAPTSMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119174754-A Use of Ipriflavone in combating respiratory syncytial virus infection 苏州大学 2024-12-24 CN claimed
US-12630534-B2 1-((1H-pyrazol-4-yl)methyl)-3-(phenyl)-1,3-dihydro-2H-imidazol-2-one derivatives and related compounds as GPR139 antagonists for the treatment of e.g. depression TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2026-05-19 US disclosed
US-12594249-B2 Soluble curcumin and its derivatives THERMOLIFE INTERNATIONAL, LLC (US) 2026-04-07 US disclosed
US-12590086-B2 3-((1H-pyrazol-4-yl)methyl)-6′-(phenyl)-2H-(1,2′-bipyridin)-2-one derivatives and related compounds as GPR139 antagonists for use in a method of treatment of e.g. depression TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2026-03-31 US disclosed
CN-119174754-B Use of Ipriflavone in combating respiratory syncytial virus infection 苏州大学 2025-09-26 CN disclosed
CN-119174754-B Use of Ipriflavone in combating respiratory syncytial virus infection 苏州大学 2025-09-26 CN disclosed
EP-4340868-B1 SECRETED SPLICING VARIANT OF KLOTHO FOR TREATING BONE DISORDERS UNIV AUTòNOMA DE BARCELONA (ES) 2025-07-09 EP disclosed
US-20250213601-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR THE TREATMENT OF VIRAL DISEASES Didenko, Kirill (US) 2025-07-03 US disclosed
US-20250144067-A1 PERSONALIZED STARVATION THERAPY FOR CANCER FAETH THERAPEUTICS, INC. 2025-05-08 US disclosed
WO-2024250032-A9 SOLUBLE CURCUMIN AND ITS DERIVATIVES THERMOLIFE INTERNATIONAL, LLC (US) 2025-03-06 WO disclosed
WO-2022243519-A1 SECRETED SPLICING VARIANT OF KLOTHO FOR TREATING BONE DISORDERS UNIVERSITAT AUTÒNOMA DE BARCELONA (ES) 2022-11-24 WO disclosed
US-11491123-B2 Pharmaceutical compositions with antiflaviviral activity HEALTH RESEARCH, INC. (US) 2022-11-08 US disclosed
EP-4071473-A1 METHOD FOR ASSOCIATING WITH EXPRESSION LEVEL OF AKR1C3 ENZYME VIA CONTENT OF PROSTAGLANDIN, AND USE OF SCREENING FOR DRUG ADMINISTRATION Ascentawits Pharmaceuticals, Ltd. (CN) 2022-10-12 EP disclosed
EP-4062772-A2 ENCLOSING MATERIALS IN NATURAL TRANSPORT SYSTEMS Incredible Foods, Inc. (US) 2022-09-28 EP disclosed
CN-112386702-B Compositions and methods for reducing drug tolerance in patients with hormone-dependent diseases 中国科学院分子细胞科学卓越创新中心 2022-08-30 CN disclosed
CN-114931573-A Application of ipriflavone in inhibiting activation of NLRP3 inflammatory corpuscle 浙江中医药大学 2022-08-23 CN disclosed
WO-2022163852-A1 COMPOSITION FOR INHIBITING EXPRESSION OF ANGIOTENSIN CONVERTING ENZYME 2 (ACE2) AND/OR TMPRSS2 株式会社 バイオミメティクスシンパシーズ 2022-08-04 WO disclosed
US-11400106-B2 Methods for inhibiting microbe growth MCMASTER UNIVERSITY (CA) 2022-08-02 US disclosed
CN-114414608-A Method for detecting SIRTs deacetylase activity based on one-dimensional HNCO nuclear magnetic resonance spectrum and application 深圳大学 2022-04-29 CN disclosed
WO-2022034664-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BONE DISEASES 株式会社ジェクスヴァル 2022-02-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11491123-B2 Pharmaceutical compositions with antiflaviviral activity ETFB, ETFA, TTN ALDH1A1 3139/4885MAPT 861/4885SMN1; SMN2 331/4885
US-12590086-B2 3-((1H-pyrazol-4-yl)methyl)-6′-(phenyl)-2H-(1,2′-bipyridin)-2-one derivatives and related compounds as GPR139 antagonists for use in a method of treatment of e.g. depression GPR139, OPRL1, GRIN2C ALDH1A1 1460/4885MAPT 413/4885SMN1; SMN2 1227/4885
US-11400106-B2 Methods for inhibiting microbe growth MMP8, BPGM, CAPG ALDH1A1 1494/4885MAPT 4695/4885SMN1; SMN2 2930/4885
US-20250213601-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR THE TREATMENT OF VIRAL DISEASES ACE2, FURIN, SARS1 ALDH1A1 2943/4885MAPT 330/4885SMN1; SMN2 831/4885
US-12594249-B2 Soluble curcumin and its derivatives SLC2A8, SLC2A2, SLC2A1 ALDH1A1 435/4885MAPT 299/4885SMN1; SMN2 2615/4885
US-12630534-B2 1-((1H-pyrazol-4-yl)methyl)-3-(phenyl)-1,3-dihydro-2H-imidazol-2-one derivatives and related compounds as GPR139 antagonists for the treatment of e.g. depression GPR139, OPRL1, GRIN2C ALDH1A1 1685/4885MAPT 360/4885SMN1; SMN2 844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.