Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3369562 | 0.81 | KDM4E (0.58) | KDM4EKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL7028782 | 0.81 | ALDH1A1 (0.52) | KDM4EKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL27426758 | 0.81 | ALDH1A1 (0.44) | KDM4EKMT2AMAPTALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL7035251 | 0.80 | ALDH1A1 (0.51) | KDM4EKMT2AMAPTALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL27403072 | 0.80 | ALDH1A1 (0.43) | KDM4EKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL9527282 | 0.79 | KDM4E (0.41) | KDM4EKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL23460209 | 0.79 | KDM4E (0.57) | KDM4EKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL3230676 | 0.79 | KDM4E (0.57) | KDM4EKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL1845347 | 0.79 | KDM4E (0.57) | KDM4EKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL163725 | 0.79 | KDM4E (0.57) | KDM4EKMT2AMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4514808-B1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS INC (US) | 2025-12-17 | — | — | EP | disclosed |
| EP-4514807-B1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS INC (US) | 2025-12-17 | — | — | EP | disclosed |
| US-20250340564-A1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS INC (US) | 2025-11-06 | — | — | US | disclosed |
| US-20250340570-A1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS INC (US) | 2025-11-06 | — | — | US | disclosed |
| US-20250340571-A1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS INC (US) | 2025-11-06 | — | — | US | disclosed |
| US-12384797-B2 | Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia | PTC THERAPEUTICS, INC. (US) | 2025-08-12 | — | — | US | disclosed |
| US-20250101034-A1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2025-03-27 | — | — | US | disclosed |
| EP-4514807-A1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | Skyhawk Therapeutics, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| EP-4514808-A1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | Skyhawk Therapeutics, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| CN-115151550-B | External nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP 1) modulators and uses thereof | 桑福德·伯纳姆·普雷比医学发现研究所 | 2024-11-22 | — | — | CN | disclosed |
| US-7763643-B2 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-07-27 | — | — | US | disclosed |
| US-20090137630-A1 | SUBSTITUTED THIOPHENES: COMPOSITIONS, PROCESSES OF MAKING, AND USES IN DISEASE TREATMENT AND DIAGNOSIS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-05-28 | — | — | US | disclosed |
| US-7488746-B2 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-02-10 | — | — | US | disclosed |
| US-20080070947-A1 | SUBSTITUTED THIOPHENES: COMPOSITIONS, PROCESSES OF MAKING, AND USES IN DISEASE TREATMENT AND DIAGNOSIS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-20 | — | — | US | disclosed |
| US-7317033-B2 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-01-08 | — | — | US | disclosed |
| US-7179830-B2 | Substituted thienoimidazoles useful for disease treatment and prevention | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-02-20 | — | — | US | disclosed |
| US-20060160873-A1 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-20 | — | — | US | disclosed |
| US-7049333-B2 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-05-23 | — | — | US | disclosed |
| US-20050075385-A1 | Substituted thienoimidazoles useful for disease treatment and prevention | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-04-07 | — | — | US | disclosed |
| US-20040006119-A1 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137630-A1 | SUBSTITUTED THIOPHENES: COMPOSITIONS, PROCESSES OF MAKING, AND USES IN DISEASE TREATMENT AND DIAGNOSIS | PLAT, CPS1, TST | KDM4E 2821/4885KMT2A 3784/4885MAPT 3886/4885 |
| US-20040006119-A1 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | TST, GOT2, ALPP | KDM4E 2986/4885KMT2A 3747/4885MAPT 3261/4885 |
| US-20080070947-A1 | SUBSTITUTED THIOPHENES: COMPOSITIONS, PROCESSES OF MAKING, AND USES IN DISEASE TREATMENT AND DIAGNOSIS | PLAT, TST, PNLIP | KDM4E 2875/4885KMT2A 3668/4885MAPT 3447/4885 |
| US-20250101034-A1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | RBM17, SNRPE, SNRPA1 | KDM4E 3676/4885KMT2A 3059/4885MAPT 3190/4885 |
| US-20060160873-A1 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis | PLAT, TST, PNLIP | KDM4E 2875/4885KMT2A 3668/4885MAPT 3447/4885 |
| US-20250340570-A1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | RBM17, SF3A2, SMN1; SMN2 | KDM4E 4041/4885KMT2A 3380/4885MAPT 2061/4885 |
| US-12384797-B2 | Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia | SF3B5, SF3B2, SF3B1 | KDM4E 2301/4885KMT2A 2237/4885MAPT 863/4885 |
| US-20250340571-A1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | RBM17, RBM22, U2AF1 | KDM4E 3826/4885KMT2A 3175/4885MAPT 3166/4885 |
| US-20250340564-A1 | COMPOSITIONS USEFUL FOR MODULATING SPLICING | RBM17, SNRPE, SNRPA1 | KDM4E 3676/4885KMT2A 3059/4885MAPT 3190/4885 |
| US-20050075385-A1 | Substituted thienoimidazoles useful for disease treatment and prevention | TPMT, TYMS, SLC19A2 | KDM4E 3744/4885KMT2A 2585/4885MAPT 3943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.