Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29785251 | 1.00 | WDR5 (0.34) | WDR5NPSR1POLBAPOBEC3ACASP6 | |
| SCHEMBL38662081 | 1.00 | WDR5 (0.34) | WDR5NPSR1POLBAPOBEC3ACASP6 | |
| SCHEMBL7521120 | 0.90 | GPR84 (0.32) | WDR5NPSR1 | |
| SCHEMBL17747337 | 0.87 | HKDC1 (0.32) | NPSR1POLBKMT2ACTDSP1 | |
| SCHEMBL7117366 | 0.87 | — | — | |
| SCHEMBL132989 | 0.85 | WDR5 (0.44) | WDR5NPSR1POLBDNMT1 | |
| SCHEMBL29382484 | 0.85 | WDR5 (0.44) | WDR5NPSR1POLBDNMT1 | |
| Phosphoric Acid SCHEMBL17352912 | 0.82 | WDR5 (0.43) | WDR5DNMT1 | |
| SCHEMBL6932286 | 0.82 | — | — | |
| SCHEMBL5107 | 0.82 | ALDH1A1 (0.44) | WDR5DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11591314-B2 | Process for preparing tetrahydrocarbazole carboxamide compound | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-02-28 | — | — | US | claimed |
| CN-110312713-B | Process for preparing tetrahydrocarbazole carboxamide compounds | 百时美施贵宝公司 | 2022-08-12 | — | — | CN | claimed |
| US-20210078980-A1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | BRISTOL MYERS SQUIBB CO (US) | 2021-03-18 | — | — | US | claimed |
| US-10875843-B2 | Process for preparing tetrahydrocarbazole carboxamide compound | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-12-29 | — | — | US | claimed |
| EP-3558977-B1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | BRISTOL MYERS SQUIBB CO (US) | 2020-10-28 | — | — | EP | claimed |
| US-20200109133-A1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | BRISTOL MYERS SQUIBB CO (US) | 2020-04-09 | — | — | US | claimed |
| EP-3558977-A1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | Bristol-Myers Squibb Company (US) | 2019-10-30 | — | — | EP | claimed |
| WO-2018118830-A1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-06-28 | — | — | WO | claimed |
| US-20240158424-A1 | METHOD FOR PRODUCING DIPHOSPHINE MONOXIDE | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2024-05-16 | — | — | US | disclosed |
| EP-4361162-A2 | METHOD FOR PRODUCING DIPHOSPHINE MONOXIDE | Takasago International Corporation (JP) | 2024-05-01 | — | — | EP | disclosed |
| US-11591314-B2 | Process for preparing tetrahydrocarbazole carboxamide compound | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-02-28 | — | — | US | disclosed |
| CN-110312713-B | Process for preparing tetrahydrocarbazole carboxamide compounds | 百时美施贵宝公司 | 2022-08-12 | — | — | CN | disclosed |
| US-20210078980-A1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | BRISTOL MYERS SQUIBB CO (US) | 2021-03-18 | — | — | US | disclosed |
| US-10875843-B2 | Process for preparing tetrahydrocarbazole carboxamide compound | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-12-29 | — | — | US | disclosed |
| US-20060063933-A1 | Process for production of carebastine | AMR TECHNOLOGY, INC. (US) | 2006-03-23 | — | — | US | disclosed |
| EP-0771812-B1 | Method for producing an optically active diphosphine | TAKASAGO PERFUMERY CO LTD (JP) | 2003-12-10 | — | — | EP | disclosed |
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |
| US-5922918-A | Method for making an optically active diphosphine ligand | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1999-07-13 | — | — | US | disclosed |
| EP-0839819-A1 | Method of preparing optically active diphosphine ligands | Takasago International Corporation (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5693868-A | REACTING 2,2'-BIS(TRIFLUOROMETHANESULFONYLOXY)-1,1-BINAPHTHYL WITH A PHOSPHINE OXIDE IN THE PRESENCE OF A TRANSITION METAL-PHOSPHINE COMPLEX | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1997-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240158424-A1 | METHOD FOR PRODUCING DIPHOSPHINE MONOXIDE | TDO2, SCO2, DUOX1 | WDR5 692/4885NPSR1 3080/4885POLB 296/4885 |
| US-20210078980-A1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | CYP2C8, CYP3A7, PARP8 | WDR5 3701/4885NPSR1 2714/4885POLB 507/4885 |
| US-11591314-B2 | Process for preparing tetrahydrocarbazole carboxamide compound | CYP2C8, CYP3A7, PARP8 | WDR5 3701/4885NPSR1 2714/4885POLB 507/4885 |
| US-10875843-B2 | Process for preparing tetrahydrocarbazole carboxamide compound | CYP2C8, CYP3A7, CDK8 | WDR5 3458/4885NPSR1 3096/4885POLB 534/4885 |
| US-20060063933-A1 | Process for production of carebastine | GABRE, GABRB3, GABRB2 | WDR5 4184/4885NPSR1 1706/4885POLB 178/4885 |
| US-20200109133-A1 | PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND | CYP2C8, CYP3A7, CDK8 | WDR5 3458/4885NPSR1 3096/4885POLB 534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.