Sugi Predict

Sugi Predict / Compounds / SCHEMBL303218

SCHEMBL303218

SCHEMBL303218

Clc1ccc2c(c1)OCCN2

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.49
▸ GAA P10253 2/20 0.49
▸ HSD17B10 Q99714 2/20 0.49
▸ MAPT P10636 1/20 0.49
▸ MAP3K14 Q99558 4/20 0.42
▸ EGFR P00533 3/20 0.39
▸ AHR P35869 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ GLA P06280 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ CASP1 P29466 1/20 0.39
▸ CASP7 P55210 1/20 0.39
▸ ATM Q13315 1/20 0.39
▸ TRPV1 Q8NER1 1/20 0.38
▸ HDAC11 Q96DB2 1/20 0.37
▸ FABP6 P51161 1/20 0.37
▸ AR P10275 1/20 0.36
▸ PDE3B Q13370 1/20 0.36
▸ PDE3A Q14432 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29998365 1.00 ALDH1A1 (0.49) ALDH1A1GAAHSD17B10MAPTMAP3K14
SCHEMBL1495875 0.89 CHEK1 (0.40) ALDH1A1GAAHSD17B10MAPTMAP3K14
SCHEMBL304035 0.85 ALDH1A1 (0.62) ALDH1A1GAAHSD17B10MAPTMAP3K14
SCHEMBL8469136 0.80 AHR (0.41) MAP3K14EGFRAHR
SCHEMBL24820913 0.77 ALDH1A1 (0.49) ALDH1A1GAAHSD17B10MAPTKDM4E
SCHEMBL304015 0.77 MAPT (0.49) ALDH1A1GAAHSD17B10MAPTEGFR
SCHEMBL1859632 0.77 FABP6 (0.56) ALDH1A1GAAHSD17B10MAPTEGFR
SCHEMBL2746377 0.77 ALDH1A1 (0.49) ALDH1A1GAAHSD17B10MAPTKDM4E
SCHEMBL3588662 0.77 GAA (0.49) ALDH1A1GAAHSD17B10MAPTEGFR
SCHEMBL17581725 0.77 ALDH1A1 (0.49) ALDH1A1GAAHSD17B10MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12152038-B2 Vasopressin receptor antagonists and products and methods related thereto Neumora Therapeutics, Inc. (US) 2024-11-26 — — US disclosed
US-20240158412-A1 UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS AND USES THEREOF FAXIAN THERAPEUTICS, LLC 2024-05-16 — — US disclosed
US-20240150362-A1 Substituted Pyrrolotriazines MOLECURE S.A. (PL) 2024-05-09 — — US disclosed
WO-2024042494-A1 SUBSTITUTED PYRROLOTRIAZINES MOLECURE SA (PL) 2024-02-29 — — WO disclosed
EP-4288442-A1 UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS AND USES THEREOF Faxian Therapeutics, LLC (US) 2023-12-13 — — EP disclosed
EP-3679043-B9 VASOPRESSIN RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO NEUMORA THERAPEUTICS INC (US) 2023-09-27 — — EP disclosed
EP-3679043-B9 VASOPRESSIN RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO NEUMORA THERAPEUTICS INC (US) 2023-09-27 — — EP disclosed
US-20230174523-A1 BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF AMATHUS THERAPEUTICS, INC. (US) 2023-06-08 — — US disclosed
EP-3679043-B1 VASOPRESSIN RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO NEUMORA THERAPEUTICS INC (US) 2023-05-31 — — EP disclosed
US-20230142739-A1 PROTEIN-PROTEIN INTERACTION STABILIZERS UNIV CALIFORNIA (US) 2023-05-11 — — US disclosed
WO-2019050988-A1 VASOPRESSIN RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO BLACKTHORN THERAPEUTICS, INC. (US) 2019-03-14 — — WO disclosed
WO-2019050988-A1 VASOPRESSIN RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO BLACKTHORN THERAPEUTICS, INC. (US) 2019-03-14 — — WO disclosed
CN-106536491-B Benzoxazine keto-amide as mineralcorticoid receptor regulator 阿斯利康(瑞典)有限公司 2018-12-18 — — CN disclosed
US-8093238-B2 Fused thiazole derivatives as kinase inhibitors UCB PHARMA S.A. (BE) 2012-01-10 — — US disclosed
US-20100069361-A1 Fused Thiazole Derivatives as Kinase Inhibitors UCB PHARMA S.A. (BE) 2010-03-18 — — US disclosed
CN-1021332-C Process for preparing spiro-linked pyrrolidine-2, 5-diones KYORIN SEIYAKU KK (JP) 1993-06-23 — — CN disclosed
US-4749789-A Process for the manufacture of spiro-linked pyrrolidine 2,5-diones KYORIN PHARMACEUTICAL CO., LTD. (JP) 1988-06-07 — — US disclosed
CN-87104819-A Process for preparing spiro-linked pyrrolidine-2, 5-diones — 1988-02-03 — — CN disclosed
EP-0254149-A2 The process for the manufacture of spiro-linked pyrrolidine-2,5-diones KYORIN PHARMACEUTICAL CO., LTD. (JP) 1988-01-27 — — EP disclosed
US-4288589-A Cationic dyes CIBA-GEIGY CORPORATION (US) 1981-09-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12152038-B2 Vasopressin receptor antagonists and products and methods related thereto AVPR1A, AVPR2, AVPR1B ALDH1A1 2907/4885GAA 4709/4885HSD17B10 1680/4885
US-20240158412-A1 UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS AND USES THEREOF USP7, USP28, USP1 ALDH1A1 1048/4885GAA 258/4885HSD17B10 2022/4885
US-20100069361-A1 Fused Thiazole Derivatives as Kinase Inhibitors JAK1, MTOR, MOK ALDH1A1 1714/4885GAA 1343/4885HSD17B10 2961/4885
US-20230174523-A1 BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF TRAP1, PINK1, TP53BP1 ALDH1A1 2569/4885GAA 1667/4885HSD17B10 3120/4885
US-20240150362-A1 Substituted Pyrrolotriazines USP7, UBA7, USP5 ALDH1A1 1836/4885GAA 733/4885HSD17B10 1817/4885
US-20230142739-A1 PROTEIN-PROTEIN INTERACTION STABILIZERS HSPBP1, HSPA8, HSPH1 ALDH1A1 3889/4885GAA 3615/4885HSD17B10 2477/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.