SCHEMBL30869713

SCHEMBL30869713

C[Si](C)(C)CCOCn1ncc2c(-c3ccc4c(c3)Sc3cc(-c5cccc6[nH]ncc56)ccc3N4CCN3CCOCC3)ccnc21

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 14/20 0.36
PIK3CG P48736 2/20 0.36
TGFBR1 P36897 1/20 0.34
PIK3R1 P27986 2/20 0.34
PIK3CD O00329 2/20 0.34
CHUK O15111 1/20 0.34
INSR P06213 1/20 0.34
MAPK8 P45983 1/20 0.34
CAMKK2 Q96RR4 1/20 0.34
KDM1A O60341 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869756 0.82 PIK3CG (0.49) PIK3CAPIK3CGPIK3R1PIK3CDKDM1A
SCHEMBL30869711 0.82 PRKCQ (0.45) PIK3CAPIK3CGPIK3CDKDM1A
SCHEMBL30869650 0.75 PIK3CD (0.47) PIK3CATGFBR1PIK3CDKDM1A
SCHEMBL30869587 0.74 PIK3CG (0.41) PIK3CAPIK3CGPIK3R1PIK3CDKDM1A
SCHEMBL30869729 0.69 PIK3CG (0.48) PIK3CAPIK3CGPIK3R1PIK3CD
SCHEMBL30869663 0.69 CD274 (0.39) KDM1A
SCHEMBL32682887 0.67 EGFR (0.52) PIK3CAMAPK8KDM1A
SCHEMBL30869697 0.66 BRAF (0.42)
SCHEMBL30869877 0.66 PIK3CD (0.48) PIK3CATGFBR1PIK3CD
SCHEMBL32682882 0.64 KDM1A (0.47) KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260070880-A1 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES, INC. (US) 2026-03-12 US disclosed
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070880-A1 DYNAMIN ACTIVATORS DNM1, DNM1L, DNM2 PIK3CA 475/4885PIK3CG 159/4885TGFBR1 3352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.