Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 3/20 | 0.51 |
| ▸ | ACE | P12821 | 5/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14407783 | 1.00 | FKBP1A (0.51) | FKBP1AACECES2CES1 | |
| SCHEMBL3397276 | 1.00 | FKBP1A (0.51) | FKBP1AACECES2CES1 | |
| SCHEMBL5834349 | 1.00 | FKBP1A (0.51) | FKBP1AACECES2CES1 | |
| SCHEMBL14394666 | 0.98 | FKBP1A (0.49) | FKBP1AACE | |
| SCHEMBL5966183 | 0.96 | FKBP1A (0.55) | FKBP1AACECES2CES1 | |
| SCHEMBL14407780 | 0.96 | FKBP1A (0.55) | FKBP1AACECES2CES1 | |
| SCHEMBL14407787 | 0.96 | FKBP1A (0.55) | FKBP1AACECES2CES1 | |
| SCHEMBL14407782 | 0.96 | FKBP1A (0.55) | FKBP1AACECES2CES1 | |
| SCHEMBL14407795 | 0.96 | FKBP1A (0.55) | FKBP1AACECES2CES1 | |
| SCHEMBL14407789 | 0.95 | FKBP1A (0.52) | FKBP1AACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100330063-A1 | STEM-LIKE CELLS, METHOD FOR DE-DIFFERENTIATING MAMMALIAN SOMATIC CELLS INTO STEM-LIKE CELLS, AND METHOD FOR DIFFERENTIATING STEM-LIKE CELLS | GLIAMED, INC. (US) | 2010-12-30 | — | — | US | claimed |
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | HAMILTON GREGORY S | 2008-03-27 | — | — | US | claimed |
| US-7282510-B2 | Small molecule inhibitors of rotamase enzyme activity | GLIAMED, INC. (US) | 2007-10-16 | — | — | US | claimed |
| EP-1227859-B1 | NEUROPHILIN LIGANDS FOR TREATING OCULAR CONDITIONS | ALCON INC (CH) | 2006-08-09 | — | — | EP | claimed |
| US-20050272780-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD NIL HOLDINGS, INC. | 2005-12-08 | — | — | US | claimed |
| US-6943187-B2 | Pyrrolidine derivative hair growth compositions and uses | GPI NIL HOLDINGS, INC. (US) | 2005-09-13 | — | — | US | claimed |
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | AMGEN INC. | 2004-09-23 | — | — | US | claimed |
| US-20040049046-A1 | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 2004-03-11 | — | — | US | claimed |
| US-20030203890-A1 | Method for treating nerve injury caused as a result of surgery | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2003-10-30 | — | — | US | claimed |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | GLIAMED, INC. | 2002-12-26 | — | — | US | claimed |
| EP-0769006-B1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2000-11-08 | — | — | EP | claimed |
| EP-0998263-A1 | PYRROLIDINE DERIVATIVE HAIR GROWTH COMPOSITIONS AND USES | GUILFORD PHARMACEUTICALS INC. (US) | 2000-05-10 | — | — | EP | claimed |
| EP-0992492-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-12 | — | — | EP | claimed |
| US-5859031-A | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 1999-01-12 | — | — | US | claimed |
| WO-1998055091-A1 | PYRROLIDINE DERIVATIVE HAIR GROWTH COMPOSITIONS AND USES | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-10 | — | — | WO | claimed |
| EP-0769006-A4 | — | GUILFORD PHARM INC (US) | 1997-05-28 | — | — | EP | claimed |
| EP-0769006-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1997-04-23 | — | — | EP | claimed |
| US-5614547-A | Small molecule inhibitors of rotamase enzyme | GUILFORD PHARMACEUTICALS INC. (US) | 1997-03-25 | — | — | US | claimed |
| WO-1996040633-A9 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | — | 1997-02-27 | — | — | WO | claimed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | GAP43, CHAT, MYOC | FKBP1A 2845/4885ACE 2889/4885CES2 2098/4885 |
| US-20030203890-A1 | Method for treating nerve injury caused as a result of surgery | NGF, BDNF, GAP43 | FKBP1A 1167/4885ACE 1092/4885CES2 933/4885 |
| US-20040049046-A1 | Small molecule inhibitors of rotamase enzyme activity | FKBP8, FKBP14, PREP | FKBP1A 4/4885ACE 371/4885CES2 1432/4885 |
| US-20050272780-A1 | Small molecule inhibitors of rotamase enzyme activity | FKBP8, FKBP1A, PREP | FKBP1A 2/4885ACE 339/4885CES2 1170/4885 |
| US-20100330063-A1 | STEM-LIKE CELLS, METHOD FOR DE-DIFFERENTIATING MAMMALIAN SOMATIC CELLS INTO STEM-LIKE CELLS, AND METHOD FOR DIFFERENTIATING STEM-LIKE CELLS | POU2F1, POU2F2, POU5F1 | FKBP1A 4746/4885ACE 4534/4885CES2 2057/4885 |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | MKI67, PLOD2, HDGF | FKBP1A 42/4885ACE 2839/4885CES2 4030/4885 |
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | FKBP8, FKBP1A, FKBP2 | FKBP1A 2/4885ACE 636/4885CES2 2010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.