Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14407800 | 1.00 | ACE (0.52) | ACEPTPN1ALDH1A1SMN1; SMN2CES2 | |
| SCHEMBL14407794 | 0.96 | ACE (0.48) | ACEPTPN1ALDH1A1SMN1; SMN2CES2 | |
| SCHEMBL14407799 | 0.95 | ACE (0.47) | ACEPTPN1ALDH1A1SMN1; SMN2CES2 | |
| SCHEMBL5310085 | 0.86 | CHRNA7 (0.56) | ACEALDH1A1SMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL15347856 | 0.82 | CHRNA7 (0.55) | ACEALDH1A1SMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL11227099 | 0.82 | ACE (0.64) | ACE | |
| SCHEMBL8810826 | 0.79 | FKBP1A (0.68) | — | |
| SCHEMBL7992283 | 0.79 | FKBP1A (0.68) | — | |
| SCHEMBL8552264 | 0.78 | ALDH1A1 (0.57) | ACEALDH1A1SMN1; SMN2ITGB3ITGB1 | |
| SCHEMBL3148908 | 0.78 | ALDH1A1 (0.57) | ACEALDH1A1SMN1; SMN2ITGB3ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | HAMILTON GREGORY S | 2008-03-27 | — | — | US | claimed |
| EP-1227859-B1 | NEUROPHILIN LIGANDS FOR TREATING OCULAR CONDITIONS | ALCON INC (CH) | 2006-08-09 | — | — | EP | claimed |
| US-20050272780-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD NIL HOLDINGS, INC. | 2005-12-08 | — | — | US | claimed |
| US-6943187-B2 | Pyrrolidine derivative hair growth compositions and uses | GPI NIL HOLDINGS, INC. (US) | 2005-09-13 | — | — | US | claimed |
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | AMGEN INC. | 2004-09-23 | — | — | US | claimed |
| US-20040049046-A1 | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 2004-03-11 | — | — | US | claimed |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | GLIAMED, INC. | 2002-12-26 | — | — | US | claimed |
| US-20010049381-A1 | Pyrrolidine derivative hair growth compositions and uses | GPL NIL HOLDINGS, INC., | 2001-12-06 | — | — | US | claimed |
| US-20010034362-A1 | Pyrrolidine derivatives for vision and memory disorders | GUILFORD PHARMACEUTICALS INC. (US) | 2001-10-25 | — | — | US | claimed |
| US-20010029263-A1 | Novel pyrrolidine carboxylate hair revitalizing agents | GPI NIL HOLDINGS, INC. | 2001-10-11 | — | — | US | claimed |
| US-6239164-B1 | IMMUNOPHILIN AFFINITY; NONIMMUNOSUPPRESSANT | GPI NIL HOLDINGS, INC. | 2001-05-29 | — | — | US | claimed |
| US-6218423-B1 | ADMINISTERING PYRROLIDINE DERIVATIVE FOR THERAPY OF NERVE-RELATED VISION DISORDER, IMPROVING VISION, TREATING MEMORY IMPAIRMENT, OR ENHANCING MEMORY PERFORMANCE IN ANIMAL | GPI NIL HOLDINGS, INC. | 2001-04-17 | — | — | US | claimed |
| US-6177455-B1 | ADMINISTERING A NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | GPI NIL HOLDINGS, INC. | 2001-01-23 | — | — | US | claimed |
| EP-0769006-B1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2000-11-08 | — | — | EP | claimed |
| EP-0992492-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-12 | — | — | EP | claimed |
| WO-2000009124-A1 | PYRROLIDINE DERIVATIVES FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | claimed |
| EP-0769006-A4 | — | GUILFORD PHARM INC (US) | 1997-05-28 | — | — | EP | claimed |
| EP-0769006-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1997-04-23 | — | — | EP | claimed |
| US-5614547-A | Small molecule inhibitors of rotamase enzyme | GUILFORD PHARMACEUTICALS INC. (US) | 1997-03-25 | — | — | US | claimed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | GAP43, CHAT, MYOC | ACE 2889/4885PTPN1 4489/4885ALDH1A1 508/4885 |
| US-20040049046-A1 | Small molecule inhibitors of rotamase enzyme activity | FKBP8, FKBP14, PREP | ACE 371/4885PTPN1 623/4885ALDH1A1 3637/4885 |
| US-20050272780-A1 | Small molecule inhibitors of rotamase enzyme activity | FKBP8, FKBP1A, PREP | ACE 339/4885PTPN1 801/4885ALDH1A1 3358/4885 |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | MKI67, PLOD2, HDGF | ACE 2839/4885PTPN1 2441/4885ALDH1A1 757/4885 |
| US-20010034362-A1 | Pyrrolidine derivatives for vision and memory disorders | PDE6D, PDE6C, PDE4D | ACE 3129/4885PTPN1 3711/4885ALDH1A1 2196/4885 |
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | FKBP8, FKBP1A, FKBP2 | ACE 636/4885PTPN1 668/4885ALDH1A1 3064/4885 |
| US-20010029263-A1 | Novel pyrrolidine carboxylate hair revitalizing agents | PDCD1, PDCD4, PDCD5 | ACE 3740/4885PTPN1 163/4885ALDH1A1 1810/4885 |
| US-20010049381-A1 | Pyrrolidine derivative hair growth compositions and uses | MKI67, PLOD2, HDGF | ACE 2839/4885PTPN1 2441/4885ALDH1A1 757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.