Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.62 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.58 |
| ▸ | MPL | P40238 | 8/20 | 0.58 |
| ▸ | CTRC | Q99895 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | PTPRA | P18433 | 1/20 | 0.57 |
| ▸ | PTPRB | P23467 | 1/20 | 0.57 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL107958 | 0.99 | CYP1A2 (0.63) | CYP1A2CYP2C9TSHRCYP2C19HSD17B10 | |
| SCHEMBL107959 | 0.99 | CYP1A2 (0.63) | CYP1A2CYP2C9TSHRCYP2C19HSD17B10 | |
| SCHEMBL1435931 | 0.98 | CYP1A2 (0.62) | CYP1A2CYP2C9TSHRCYP2C19HSD17B10 | |
| SCHEMBL1435926 | 0.98 | CYP1A2 (0.62) | CYP1A2CYP2C9TSHRCYP2C19HSD17B10 | |
| SCHEMBL1435929 | 0.92 | CYP1A2 (0.54) | CYP1A2CYP2C9TSHRCYP2C19HSD17B10 | |
| SCHEMBL24026914 | 0.84 | PRMT1 (0.50) | CYP1A2CYP2C9TSHRCYP2C19HSD17B10 | |
| SCHEMBL24026725 | 0.83 | HPGD (0.51) | CYP1A2CYP2C9TSHRCYP2C19HSD17B10 | |
| SCHEMBL8912216 | 0.83 | CYP1A2 (0.64) | CYP1A2CYP2C9TSHRCYP2C19HSD17B10 | |
| SCHEMBL29259111 | 0.83 | CYP1A2 (0.67) | CYP1A2CYP2C9TSHRCYP2C19HSD17B10 | |
| SCHEMBL11854033 | 0.82 | HPGD (0.56) | CYP1A2CYP2C9TSHRCYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2930126-B1 | Fashionable aerosol dye | HENKEL AG & CO KGAA (DE) | 2019-10-09 | — | — | EP | claimed |
| US-9173829-B2 | Compositions for dyeing keratin fibers | HENKEL AG & CO. KGAA (DE) | 2015-11-03 | — | — | US | disclosed |
| US-9161898-B2 | Compositions for colouring keratin fibres | HENKEL AG & CO. KGAA (DE) | 2015-10-20 | — | — | US | disclosed |
| US-20140298592-A1 | COMPOSITIONS FOR DYEING KERATIN FIBERS | HENKEL AG & CO. KGAA (DE) | 2014-10-09 | — | — | US | disclosed |
| US-20140290690-A1 | COMPOSITIONS FOR COLOURING KERATIN FIBRES | HENKEL AG & CO. KGAA (DE) | 2014-10-02 | — | — | US | disclosed |
| US-20100021396-A1 | TINTING MOUSSE | HENKEL AG & CO. KGAA (DE) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140290690-A1 | COMPOSITIONS FOR COLOURING KERATIN FIBRES | KRT18, DSG1, PKN1 | THRB 4544/4885CYP1A2 1749/4885CYP2C9 1717/4885 |
| US-20140298592-A1 | COMPOSITIONS FOR DYEING KERATIN FIBERS | KRT18, PKN3, IK | THRB 3252/4885CYP1A2 3680/4885CYP2C9 4227/4885 |
| US-20100021396-A1 | TINTING MOUSSE | KRT18, MSN, MFAP1 | THRB 4316/4885CYP1A2 2191/4885CYP2C9 3411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.