Protocatechuic Acid

Protocatechuic Acid

SCHEMBL3196359

O.O=C(O)c1ccc(O)c(O)c1

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Protocatechuic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 known ✓ P35354 1/20 0.95
HDAC6 known ✓ Q9UBN7 1/20 0.56
DPP4 known ✓ P27487 1/20 0.54
TOP1 known ✓ P11387 2/20 0.52
CA12 O43570 5/20 0.95
CA1 P00915 5/20 0.95
CA2 P00918 5/20 0.95
CA7 P43166 5/20 0.95
CA9 Q16790 5/20 0.95
CA14 Q9ULX7 5/20 0.95
KDM4E B2RXH2 3/20 0.95
CA4 P22748 3/20 0.95
CA6 P23280 3/20 0.95
MAPT P10636 2/20 0.95
GAA P10253 2/20 0.95
POLB P06746 1/20 0.95
L3MBTL1 Q9Y468 1/20 0.95
HTT P42858 1/20 0.55
TP53 P04637 2/20 0.54
CA3 P07451 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Protocatechuic Acid SCHEMBL30767247 1.00 CA12 (0.95) CA12CA1CA2CA7CA9
Protocatechuic Acid SCHEMBL29350008 0.97 CA12 (1.00) CA12CA1CA2CA7CA9
Protocatechuic Acid SCHEMBL27815804 0.97 CA12 (1.00) CA12CA1CA2CA7CA9
Protocatechuic Acid SCHEMBL30030432 0.97 CA12 (1.00) CA12CA1CA2CA7CA9
Protocatechuic Acid SCHEMBL39435 0.97 CA12 (1.00) CA12CA1CA2CA7CA9
Protocatechuic Acid SCHEMBL3189340 0.95 CA12 (0.86) CA12CA1CA2CA7CA9
Protocatechuic Acid SCHEMBL23495982 0.95 CA12 (0.95) CA12CA1CA2CA7CA9
Protocatechuic Acid SCHEMBL2274950 0.95 CA12 (0.95) CA12CA1CA2CA7CA9
Protocatechuic Acid SCHEMBL9491440 0.95 CA12 (0.95) CA12CA1CA2CA7CA9
Protocatechuic Acid SCHEMBL30677996 0.95 CA12 (0.95) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200205541-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND L'OREAL (FR) 2020-07-02 US claimed
US-20130298933-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND L'OREAL (FR) 2013-11-14 US claimed
US-20100300472-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND L'OREAL S.A. (FR) 2010-12-02 US claimed
US-20240415792-A1 METHODS AND COMPOSITIONS INCLUDING PROTOCATECHUIC ACID CRYSTALS FOR THE TREATMENT OF CONDITIONS CAUSED BY AN ENVELOPED VIRUS JOHNSON LANNY LEO (US) 2024-12-19 US disclosed
US-12109183-B2 Methods and compositions including protocatechuic acid crystals for the treatment of conditions caused by an enveloped virus JOHNSON LANNY LEO (US) 2024-10-08 US disclosed
US-11759443-B2 Methods and compositions including protocatechuic acid crystals for the treatment of respiratory syncytial virus JOHNSON LANNY LEO (US) 2023-09-19 US disclosed
US-11731927-B2 Cocrystals of ubiquinol and compositions comprising them CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L. (ES) 2023-08-22 US disclosed
WO-2023081198-A1 METHODS AND COMPOSITIONS INCLUDING PROTOCATECHUIC ACID CRYSTALS FOR THE TREATMENT OF CONDITIONS CAUSED BY AN ENVELOPED VIRUS JOHNSON LANNY LEO (US) 2023-05-11 WO disclosed
WO-2023038776-A1 COMPOSITIONS AND TREATMENTS FOR MICROBIAL PERSISTER CELLS JOHNSON LANNY LEO (US) 2023-03-16 WO disclosed
US-20220296545-A1 METHODS AND COMPOSITIONS INCLUDING PROTOCATECHUIC ACID CRYSTALS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS JOHNSON LANNY LEO (US) 2022-09-22 US disclosed
US-11399611-B2 Process for straightening keratin fibres with a heating means and denaturing agents L'OREAL (FR) 2022-08-02 US disclosed
US-20170073335-A1 1,3-BENZODIOXOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-03-16 US disclosed
EP-3121175-A1 1,3-BENZODIOXOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-01-25 EP disclosed
CN-104379729-A Useful microorganism, and method for producing desired substance GENARIS INC 2015-02-25 CN disclosed
US-20140326268-A1 PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS L'OREAL (FR) 2014-11-06 US disclosed
US-8765107-B2 Process for straightening keratin fibres with a heating means and denaturing agents L'OREAL (FR) 2014-07-01 US disclosed
US-20130298933-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND L'OREAL (FR) 2013-11-14 US disclosed
US-20120192888-A1 PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS L 'Oréal S.A., (FR) 2012-08-02 US disclosed
US-20100300472-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND L'OREAL S.A. (FR) 2010-12-02 US disclosed
US-20100028280-A1 PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS L'OREAL S.A. (FR) 2010-02-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120192888-A1 PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS KRT18, KRTCAP2, TUBB4A PTGS2 2563/4885HDAC6 354/4885DPP4 4004/4885
US-20200205541-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND KRT18, TUBB4A, TUBB4B PTGS2 3620/4885HDAC6 511/4885DPP4 3439/4885
US-11399611-B2 Process for straightening keratin fibres with a heating means and denaturing agents KRT18, KRTCAP2, TUBB4A PTGS2 2563/4885HDAC6 354/4885DPP4 4004/4885
US-20100028280-A1 PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS KRT18, KRTCAP2, TUBB4A PTGS2 2563/4885HDAC6 354/4885DPP4 4004/4885
US-20170073335-A1 1,3-BENZODIOXOLE DERIVATIVE EZH1, EZH2, BMI1 PTGS2 2035/4885HDAC6 58/4885DPP4 950/4885
US-11731927-B2 Cocrystals of ubiquinol and compositions comprising them NDUFS6, NDUFV2, NDUFA6 PTGS2 616/4885HDAC6 959/4885DPP4 3345/4885
US-20100300472-A1 METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND KRT18, TUBB4A, TUBB4B PTGS2 3620/4885HDAC6 511/4885DPP4 3439/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.