Sugi Predict

Sugi Predict / Compounds / SCHEMBL3222039

SCHEMBL3222039

SCHEMBL3222039

CCOC(=O)C1=CCN(Cc2ccccc2)C1

nearest known ligand 0.76

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.48
▸ MEN1 O00255 2/20 0.48
▸ KMT2A Q03164 2/20 0.48
▸ MAPT P10636 1/20 0.48
▸ ADORA1 P30542 1/20 0.48
▸ MAPK1 P28482 3/20 0.48
▸ TSHR P16473 1/20 0.48
▸ PRMT1 Q99873 1/20 0.47
▸ CASP3 P42574 1/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ TRPC5 Q9UL62 1/20 0.45
▸ CYP3A4 P08684 1/20 0.44
▸ CYP2D6 P10635 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44
▸ CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15312239 0.88 LMNA (0.47) LMNAMEN1KMT2AMAPTADORA1
SCHEMBL5778817 0.88 MEN1 (0.56) LMNAMEN1KMT2AMAPTADORA1
SCHEMBL7534318 0.86 MEN1 (0.47) LMNAMEN1KMT2AMAPTALDH1A1
SCHEMBL5327640 0.82 CRHBP (0.43) LMNAMEN1KMT2AALDH1A1
SCHEMBL1344511 0.81 CYP2D6 (0.46) LMNAKMT2ATSHRALDH1A1CYP3A4
SCHEMBL28039452 0.81 SIGMAR1 (0.47) LMNAMEN1KMT2AMAPK1TSHR
SCHEMBL15315351 0.80 LMNA (0.47) LMNAMEN1KMT2AMAPTADORA1
SCHEMBL8319696 0.78 MEN1 (0.46) LMNAMEN1KMT2AMAPTADORA1
SCHEMBL4111304 0.78 KMT2A (0.49) MEN1KMT2AMAPTTSHRALDH1A1
SCHEMBL20314913 0.77 ALDH1A1 (0.42) LMNAMEN1KMT2AMAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122079960-A Alkynyl quinazoline compounds — 2026-05-26 — — CN disclosed
EP-4013749-B1 ALKYNYL QUINAZOLINE COMPOUNDS BLACK DIAMOND THERAPEUTICS INC (US) 2026-03-11 — — EP disclosed
US-20260049063-A1 ALKYNYL QUINAZOLINE COMPOUNDS BLACK DIAMOND THERAPEUTICS INC (US) 2026-02-19 — — US disclosed
US-12435046-B2 Alkynyl quinazoline compounds BLACK DIAMOND THERAPEUTICS, INC. (US) 2025-10-07 — — US disclosed
CN-119390683-A Alkynyl quinazoline compounds 黑钻治疗公司 2025-02-07 — — CN disclosed
US-20220298120-A1 ALKYNYL QUINAZOLINE COMPOUNDS BLACK DIAMOND THERAPEUTICS, INC. 2022-09-22 — — US disclosed
CN-114787150-A Alkynyl quinazoline compounds 黑钻治疗公司 2022-07-22 — — CN disclosed
EP-4013749-A1 ALKYNYL QUINAZOLINE COMPOUNDS Black Diamond Therapeutics, Inc. (US) 2022-06-22 — — EP disclosed
WO-2021030711-A1 ALKYNYL QUINAZOLINE COMPOUNDS BLACK DIAMOND THERAPEUTICS, INC. (US) 2021-02-18 — — WO disclosed
WO-2021030711-A1 ALKYNYL QUINAZOLINE COMPOUNDS BLACK DIAMOND THERAPEUTICS, INC. (US) 2021-02-18 — — WO disclosed
US-20110263613-A1 COMPOUNDS AND COMPOSITIONS FOR COGNITION-ENHANCEMENT, METHODS OF MAKING, AND METHODS OF TREATING MAPLIGHT THERAPEUTICS, INC. 2011-10-27 — — US disclosed
US-20110263613-A1 COMPOUNDS AND COMPOSITIONS FOR COGNITION-ENHANCEMENT, METHODS OF MAKING, AND METHODS OF TREATING MAPLIGHT THERAPEUTICS, INC. 2011-10-27 — — US disclosed
US-20100069351-A1 SPIRO COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-03-18 — — US disclosed
EP-0690862-B1 QUINOLONE DERIVATIVES AND PROCESSES FOR PREPARING THE SAME KOREA RES INST CHEM TECH (KR) 2002-07-10 — — EP disclosed
US-5783708-A HEXAHYDROISOINDOLE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1998-07-21 — — US disclosed
US-5770597-A ANTIBIOTIC KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1998-06-23 — — US disclosed
US-5703094-A Quinolone- and naphthyridonecarboxylic acid derivatives BAYER AKTIENGESELLSCHAFT (DE) 1997-12-30 — — US disclosed
US-5679689-A BACTERICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-10-21 — — US disclosed
EP-0690862-A1 NOVEL QUINOLONE DERIVATIVES AND PROCESSES FOR PREPARING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1996-01-10 — — EP disclosed
WO-1994015938-A1 NOVEL QUINOLONE DERIVATIVES AND PROCESSES FOR PREPARING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1994-07-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12435046-B2 Alkynyl quinazoline compounds GLS, GLS2, MCL1 LMNA 557/4885MEN1 1389/4885KMT2A 4174/4885
US-20100069351-A1 SPIRO COMPOUND AND USE THEREOF SCD, SPR, SCD5 LMNA 400/4885MEN1 3647/4885KMT2A 2574/4885
US-20110263613-A1 COMPOUNDS AND COMPOSITIONS FOR COGNITION-ENHANCEMENT, METHODS OF MAKING, AND METHODS OF TREATING CHRM3, ACHE, CHRM4 LMNA 4269/4885MEN1 1991/4885KMT2A 3182/4885
US-20220298120-A1 ALKYNYL QUINAZOLINE COMPOUNDS GLS, GLS2, MCL1 LMNA 557/4885MEN1 1389/4885KMT2A 4174/4885
US-20260049063-A1 ALKYNYL QUINAZOLINE COMPOUNDS H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, MCL1, BCL6 LMNA 487/4885MEN1 1318/4885KMT2A 3453/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.