SCHEMBL3223482

SCHEMBL3223482

CCn1c2c(c3ccccc31)-c1ccccc1C2[Ti](C)(C)(NC(C)(C)C)[SiH](C)C

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
KDM4E B2RXH2 1/20 0.32
RCE1 Q9Y256 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5041930 0.86 MEN1 (0.32) MEN1KMT2AKDM4ERCE1ALDH1A1
SCHEMBL3221291 0.75 MEN1 (0.31) MEN1KMT2A
SCHEMBL28436475 0.75 GPR3 (0.32) MEN1KMT2A
SCHEMBL3224020 0.73 MAPT (0.39) MEN1KMT2AKDM4EALDH1A1MAPK1
SCHEMBL4373398 0.71 ALDH1A1 (0.35) MEN1KMT2AKDM4ERCE1ALDH1A1
SCHEMBL4540619 0.62
SCHEMBL7128408 0.61 GPR3 (0.40) MEN1KMT2AKDM4EALDH1A1MAPK1
Hydrochloric Acid SCHEMBL7128380 0.61 GPR3 (0.37) KDM4EALDH1A1MAPK1
SCHEMBL29006005 0.61
SCHEMBL28437526 0.61

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7799722-B2 Catalyst system for the polymerization of olefin BASELL POLYOLEFINE GMBH (DE) 2010-09-21 US disclosed
EP-1533324-B1 A ligand for a metallocene catalyst used to prepare propylene based polymers, and its preparation method BASELL POLYOLEFINE GMBH (DE) 2009-05-06 EP disclosed
US-20080281062-A1 Catalyst System for the Polymerization of Olefin BASELL POLYOLEFINE GMBH (DE) 2008-11-13 US disclosed
EP-1381618-B1 PROCESS FOR THE PRODUCTION OF MONOHALIDE OR DIHALIDE METALLOCENE COMPOUNDS BASELL POLYOLEFINE GMBH (DE) 2008-05-07 EP disclosed
US-7365137-B2 Multistep process for the (co) polymerization of olefins BASELL POLYOLEFINE GMBH (DE) 2008-04-29 US disclosed
US-7115761-B2 Process for the production of monohalide or dihalide metallocene compounds BASELL POLYOLEFINE GMBH (DE) 2006-10-03 US disclosed
US-20060025621-A1 Process for the production of monohalide or dihalide metallocene compounds BASELL POLYOLEFINE GMBH (DE) 2006-02-02 US disclosed
US-6987196-B2 Process for the production of monohalide or dihalide metallocene compounds BASELL POLYOLEFINE GMBH (DE) 2006-01-17 US disclosed
EP-1533324-A2 A ligand for a metallocene catalyst used to prepare propylene based polymers, and its preparation method Basell Polyolefine GmbH (DE) 2005-05-25 EP disclosed
EP-1159310-B1 PROCESS FOR PRODUCING SUBSTANTIALLY AMORPHOUS PROPYLENE-BASED POLYMERS BASELL POLYOLEFINE GMBH (DE) 2005-03-30 EP disclosed
US-20040242815-A1 Multistep process for the (co) polymerization of olefins BASELL POLYOLEFINE GMBH (DE) 2004-12-02 US disclosed
US-20040147770-A1 Process for the production of monohalide or dihalide metallocene compounds EQUISTAR CHEMICALS, LP 2004-07-29 US disclosed
US-6730754-B2 COORDINATION POLYMERIZATION CATALYST BASELL POLYOLEFINE GMBH (DE) 2004-05-04 US disclosed
EP-1406969-A1 MULTISTEP PROCESS FOR THE (CO)POLYMERIZATION OF OLEFINS Basell Polyolefine GmbH (DE) 2004-04-14 EP disclosed
EP-1381618-A2 PROCESS FOR THE PRODUCTION OF MONOHALIDE OR DIHALIDE METALLOCENE COMPOUNDS Basell Polyolefine GmbH (DE) 2004-01-21 EP disclosed
WO-2003008496-A1 MULTISTEP PROCESS FOR THE (CO)POLYMERIZATION OF OLEFINS BASELL POLYOLEFINE GMBH (DE) 2003-01-30 WO disclosed
WO-2002083699-A2 PROCESS FOR THE PRODUCTION OF MONOHALIDE OR DIHALIDE METALLOCENE COMPOUNDS BASELL POLYOLEFINE GMBH (DE) 2002-10-24 WO disclosed
US-20020147286-A1 Process for producing substantially amorphous propylene-based polymers EQUISTAR CHEMICALS, LP 2002-10-10 US disclosed
EP-1159310-A1 PROCESS FOR PRODUCING SUBSTANTIALLY AMORPHOUS PROPYLENE-BASED POLYMERS Basell Technology Company B.V. (NL) 2001-12-05 EP disclosed
WO-2001053360-A1 PROCESS FOR PRODUCING SUBSTANTIALLY AMORPHOUS PROPYLENE-BASED POLYMERS BASELL TECHNOLOGY COMPANY B.V. (NL) 2001-07-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060025621-A1 Process for the production of monohalide or dihalide metallocene compounds SOD1, HAO2, HMOX2 MEN1 2535/4885KMT2A 705/4885KDM4E 4456/4885
US-20040242815-A1 Multistep process for the (co) polymerization of olefins CCNT1, TST, SOAT1 MEN1 1242/4885KMT2A 684/4885KDM4E 3625/4885
US-20020147286-A1 Process for producing substantially amorphous propylene-based polymers GRB7, CHRM1, CPNE4 MEN1 2468/4885KMT2A 3512/4885KDM4E 4193/4885
US-20040147770-A1 Process for the production of monohalide or dihalide metallocene compounds SOD1, HAO2, MT-CO1 MEN1 2983/4885KMT2A 577/4885KDM4E 3985/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.