Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 13/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CASP2 | P42575 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
| ▸ | LIG1 | P18858 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3334809 | 0.84 | CES1 (0.62) | TGM2CES1DNMT1DAONSD2 | |
| SCHEMBL3640512 | 0.84 | CES1 (0.53) | TGM2CES1DNMT1DAONSD2 | |
| SCHEMBL20505489 | 0.84 | CES1 (0.71) | TGM2CES1DNMT1DAONSD2 | |
| SCHEMBL19210912 | 0.84 | CES1 (0.41) | TGM2CES1DNMT1DAONSD2 | |
| SCHEMBL31483785 | 0.84 | CES1 (0.62) | TGM2CES1DNMT1DAONSD2 | |
| SCHEMBL24399769 | 0.84 | TGM2 (0.43) | TGM2CES1DNMT1DAONSD2 | |
| SCHEMBL12069895 | 0.84 | TGM2 (0.43) | TGM2CES1DNMT1DAONSD2 | |
| SCHEMBL20504930 | 0.79 | L3MBTL1 (0.43) | TGM2CES1CASP3CA1CA2 | |
| SCHEMBL32089673 | 0.77 | GSK3B (0.43) | TGM2CASP3CASP2CASP7CASP6 | |
| SCHEMBL1081008 | 0.77 | GSK3B (0.43) | TGM2CASP3CASP2CASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025235362-A1 | INDOLINONE COMPOUNDS AS KCa3.1 POTASSIUM CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC (US) | 2025-11-13 | — | — | WO | disclosed |
| CN-115974759-B | Compound with antibacterial use | 中国医学科学院药物研究所 | 2025-06-17 | — | — | CN | disclosed |
| WO-2025106863-A1 | LACTAM DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-05-22 | — | — | WO | disclosed |
| EP-4522591-A1 | OXOINDOLINYL AMIDE DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF | Ventus Therapeutics U.S., Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| CN-119212978-A | Oxoindolinyl amide derivatives for inhibiting NLRP3 and use thereof | 万特斯治疗美国公司 | 2024-12-27 | — | — | CN | disclosed |
| US-20240368131-A1 | OXOINDOLINYL AMIDE DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF | VENTUS THERAPEUTICS U S INC (US) | 2024-11-07 | — | — | US | disclosed |
| WO-2023220715-A1 | OXOINDOLINYL AMIDE DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF | VENTUS THERAPEUTICS U.S., INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220715-A1 | OXOINDOLINYL AMIDE DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF | VENTUS THERAPEUTICS U.S., INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| CN-105593211-B | Indole and indazole derivatives | 豪夫迈·罗氏有限公司 | 2021-07-27 | — | — | CN | disclosed |
| EP-3049391-B1 | INDOLE AND INDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-12-26 | — | — | EP | disclosed |
| US-20080153859-A1 | MULTIPLY-SUBSTITUTED TETRAHYDRONAPHTHALENE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | REHWINKEL HARTMUT | 2008-06-26 | — | — | US | disclosed |
| US-20060229305-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | SCHERING AG (DE) | 2006-10-12 | — | — | US | disclosed |
| US-20060167025-A1 | Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs | SCHERING AG (DE) | 2006-07-27 | — | — | US | disclosed |
| US-20060084652-A1 | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | SCHERING AG (DE) | 2006-04-20 | — | — | US | disclosed |
| US-20050272823-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-12-08 | — | — | US | disclosed |
| US-20050222154-A1 | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-10-06 | — | — | US | disclosed |
| US-20050209324-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-09-22 | — | — | US | disclosed |
| US-20050171109-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-08-04 | — | — | US | disclosed |
| US-20050131226-A1 | Rearranged pentanols, a process for their production and their use as anti-inflammatory agents | SCHERING AG (DE) | 2005-06-16 | — | — | US | disclosed |
| US-20050090559-A1 | Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents | SCHERING AG (DE) | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090559-A1 | Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents | IL1B, NFKBIA, BBOX1 | TGM2 4230/4885CES1 704/4885DNMT1 3913/4885 |
| US-20060167025-A1 | Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs | ALDH7A1, NOTUM, GOT2 | TGM2 247/4885CES1 419/4885DNMT1 2355/4885 |
| US-20060084652-A1 | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | PTGES, PTGS1, PTGES2 | TGM2 1891/4885CES1 518/4885DNMT1 4341/4885 |
| US-20080153859-A1 | MULTIPLY-SUBSTITUTED TETRAHYDRONAPHTHALENE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | DHPS, TNF, IL1B | TGM2 2381/4885CES1 1189/4885DNMT1 3071/4885 |
| US-20060229305-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | PTGES, TNF, DHPS | TGM2 1423/4885CES1 535/4885DNMT1 4479/4885 |
| US-20240368131-A1 | OXOINDOLINYL AMIDE DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF | NLRP3, NLRP1, NOD1 | TGM2 2228/4885CES1 2607/4885DNMT1 4622/4885 |
| US-20050171109-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | TNF, DHPS, PTGES | TGM2 2318/4885CES1 701/4885DNMT1 3980/4885 |
| US-20050222154-A1 | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | DHPS, TNF, IL1B | TGM2 2381/4885CES1 1189/4885DNMT1 3071/4885 |
| US-20050131226-A1 | Rearranged pentanols, a process for their production and their use as anti-inflammatory agents | TNF, PTGES, PTGES2 | TGM2 3230/4885CES1 510/4885DNMT1 1568/4885 |
| US-20050272823-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | DHPS, TNF, PTGES | TGM2 2314/4885CES1 760/4885DNMT1 4024/4885 |
| US-20050209324-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | TNF, DHPS, PTGES | TGM2 2318/4885CES1 701/4885DNMT1 3980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.