SCHEMBL333323

SCHEMBL333323

[c]1nonc1Cc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.42
RAB9A P51151 5/20 0.37
SMN1; SMN2 Q16637 4/20 0.37
ALDH1A1 P00352 3/20 0.37
TDP1 Q9NUW8 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
SORT1 Q99523 1/20 0.37
NPC1 O15118 4/20 0.36
HPGD P15428 1/20 0.34
TSHR P16473 1/20 0.34
GPR55 Q9Y2T6 1/20 0.34
S1PR1 P21453 1/20 0.33
CHUK O15111 1/20 0.33
TXNRD1 Q16881 1/20 0.33
NOX4 Q9NPH5 1/20 0.33
MAPK1 P28482 1/20 0.33
HTT P42858 1/20 0.33
LMNA P02545 1/20 0.33
TAAR1 Q96RJ0 2/20 0.32
HRH3 Q9Y5N1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4995016 0.68 MEN1 (0.39) RAB9ASMN1; SMN2ALDH1A1TDP1L3MBTL1
SCHEMBL1828221 0.68 CALM1 (0.42) CALM1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL1086378 0.68 CALM1 (0.42) CALM1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL3924743 0.64 CALM1 (0.42) CALM1ALDH1A1HPGDTSHRLMNA
SCHEMBL7765645 0.64 TAAR1 (0.44) CALM1RAB9ASMN1; SMN2ALDH1A1NPC1
Diphenylmethane SCHEMBL14763944 0.64 CALM1 (1.00) CALM1ALDH1A1HPGDTSHRLMNA
Diphenylmethane SCHEMBL3792579 0.64 CALM1 (1.00) CALM1ALDH1A1HPGDTSHRLMNA
Diphenylmethane SCHEMBL1303 0.64 CALM1 (1.00) CALM1ALDH1A1HPGDTSHRLMNA
Diphenylmethane SCHEMBL4361124 0.64 CALM1 (1.00) CALM1ALDH1A1HPGDTSHRLMNA
Diphenylmethane SCHEMBL28172316 0.64 CALM1 (1.00) CALM1ALDH1A1HPGDTSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4326721-A1 SPIROCYCLIC IMIDAZOLIDINONES AND IMIDAZOLIDINEDIONES FOR TREATMENT OF LIGHT CHAIN AMYLOIDOSIS Protego Biopharma, Inc. (US) 2024-02-28 EP claimed
US-20240051960-A1 SPIROCYCLIC IMIDAZOLIDINONES AND IMIDAZOLIDINEDIONES FOR TREATMENT OF LIGHT CHAIN AMYLOIDOSIS PROTEGO BIOPHARMA, INC. 2024-02-15 US claimed
US-9371281-B2 Indole derivatives as inhibitors of histone deacetylase PHARMACYCLICS LLC (US) 2016-06-21 US claimed
US-20150299119-A1 INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE PHARMACYCLICS LLC 2015-10-22 US claimed
US-20140221322-A1 HETEROARYL SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2014-08-07 US claimed
US-20140066412-A1 HETEROARYL SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2014-03-06 US claimed
US-20110230490-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2011-09-22 US claimed
WO-2010068452-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2010-06-17 WO claimed
EP-2164493-A2 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE Janssen Pharmaceutica, N.V. (BE) 2010-03-24 EP claimed
US-20090062294-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2009-03-05 US claimed
US-20030232825-A1 Benzoxazine derivatives and uses thereof ROCHE PALO ALTO LLC 2003-12-18 US claimed
US-20030225061-A1 Protease inhibitors MARQUIS ROBERT WELLS (US) 2003-12-04 US claimed
US-20030144175-A1 Protease inhibitors SMITHKLINE BEECHAM CORPORATION 2003-07-31 US claimed
WO-2003053331-A2 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-07-03 WO claimed
EP-1307203-A1 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-05-07 EP claimed
US-20020147188-A1 Protease inhibitors SMITHKLINE BEECHAM CORPORATION 2002-10-10 US claimed
EP-1158986-A4 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORP (US) 2002-03-27 EP claimed
EP-1158986-A1 PROTEASE INHIBITORS SmithKline Beecham Corporation (US) 2001-12-05 EP claimed
WO-2001070232-A1 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2001-09-27 WO claimed
WO-2000038687-A1 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2000-07-06 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150299119-A1 INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE HDAC8, HDAC1, HDAC2 CALM1 1831/4885RAB9A 3005/4885SMN1; SMN2 3122/4885
US-20030225061-A1 Protease inhibitors CTSK, MMP13, CTSZ CALM1 2475/4885RAB9A 1322/4885SMN1; SMN2 4669/4885
US-20110230490-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, GPR119 CALM1 3881/4885RAB9A 1675/4885SMN1; SMN2 1719/4885
US-20090062294-A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, GPR119 CALM1 3881/4885RAB9A 1675/4885SMN1; SMN2 1719/4885
US-20140221322-A1 HETEROARYL SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, GPR119 CALM1 4049/4885RAB9A 1709/4885SMN1; SMN2 2038/4885
US-20030232825-A1 Benzoxazine derivatives and uses thereof CYP3A5, CYP4X1, XDH CALM1 2260/4885RAB9A 1198/4885SMN1; SMN2 3073/4885
US-20140066412-A1 HETEROARYL SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, GPR119 CALM1 4049/4885RAB9A 1709/4885SMN1; SMN2 2038/4885
US-20240051960-A1 SPIROCYCLIC IMIDAZOLIDINONES AND IMIDAZOLIDINEDIONES FOR TREATMENT OF LIGHT CHAIN AMYLOIDOSIS IGLV6-57, TTR, MAP1LC3C CALM1 2354/4885RAB9A 2375/4885SMN1; SMN2 107/4885
US-20020147188-A1 Protease inhibitors CTSK, MMP13, CTSZ CALM1 2475/4885RAB9A 1322/4885SMN1; SMN2 4669/4885
US-20030144175-A1 Protease inhibitors CTSK, MMP13, CTSZ CALM1 2475/4885RAB9A 1322/4885SMN1; SMN2 4669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.