Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cinnamic Aldehyde. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.75 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 5/20 | 0.50 |
| ▸ | CCND1 | P24385 | 5/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.50 |
| ▸ | CDK1 | P06493 | 4/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cinnamaldehyde SCHEMBL6061954 | 1.00 | ALDH1A1 (0.75) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL26923210 | 1.00 | ALDH1A1 (0.75) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL29029047 | 1.00 | ALDH1A1 (0.75) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL28719829 | 0.92 | LMNA (0.69) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL28719830 | 0.92 | LMNA (0.69) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL22729219 | 0.89 | ALDH1A1 (0.78) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL22729220 | 0.89 | ALDH1A1 (0.78) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamic Aldehyde SCHEMBL22729218 | 0.89 | ALDH1A1 (0.78) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL29206157 | 0.89 | ALDH1A1 (0.86) | ALDH1A1LMNATRPA1ALOX5MAPK1 | |
| Cinnamaldehyde SCHEMBL29206156 | 0.89 | ALDH1A1 (0.86) | ALDH1A1LMNATRPA1ALOX5MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12089620-B2 | Delivery system for food additives and its preparation | SYMRISE AG (DE) | 2024-09-17 | — | — | US | disclosed |
| EP-3554279-B1 | DELIVERY SYSTEM FOR FOOD ADDITIVES AND ITS PREPARATION | SYMRISE AG (DE) | 2021-09-22 | — | — | EP | disclosed |
| EP-3554279-A1 | DELIVERY SYSTEM FOR FOOD ADDITIVES AND ITS PREPARATION | Symrise AG (DE) | 2019-10-23 | — | — | EP | disclosed |
| US-10344247-B2 | Tetrahydrofuran derivatives as fragrances | SYMRISE AG (DE) | 2019-07-09 | — | — | US | disclosed |
| WO-2018108267-A1 | DELIVERY SYSTEM FOR FOOD ADDITIVES AND ITS PREPARATION | SYMRISE AG (DE) | 2018-06-21 | — | — | WO | disclosed |
| US-20180160710-A1 | DELIVERY SYSTEM FOR FOOD ADDITIVES AND ITS PREPARATION | SYMRISE AG (DE) | 2018-06-14 | — | — | US | disclosed |
| US-20160362644-A1 | LIQUID DETERGENT INCLUDING POLYMERS FOR INCREASING THE FRAGRANCE PERFORMANCE | HENKEL AG & CO. KGAA (DE) | 2016-12-15 | — | — | US | disclosed |
| US-20160338370-A1 | SOLID PROTEIN PREPARATIONS | DMK DEUTSCHES MILCHKONTOR GMBH (DE) | 2016-11-24 | — | — | US | disclosed |
| US-20150376546-A1 | TETRAHYDROFURAN DERIVATIVES AS FRAGRANCES | SYMRISE AG (DE) | 2015-12-31 | — | — | US | disclosed |
| US-9006169-B2 | Personal care compositions with improved hyposensitivity | THE PROCTER & GAMBLE COMPANY (US) | 2015-04-14 | — | — | US | disclosed |
| US-20120270932-A1 | Personal Care Compositions with Improved Hyposensitivity | CAHEN CHRISTINE MARIE (GB) | 2012-10-25 | — | — | US | disclosed |
| US-7807616-B2 | Geranonitrile substitute | HENKEL AG & CO. KGAA (DE) | 2010-10-05 | — | — | US | disclosed |
| US-20100143278-A1 | Low-residue deodorant or antiperspirant stick based on an oil-in-water emulsion | BANOWSKI BERNHARD | 2010-06-10 | — | — | US | disclosed |
| US-20070265183-A1 | fragrance mixture for laundering, care and/or cleaning component; producing a citrus odor; 3,7-dimethyloct-6-enenitrile mixtures; stability; nontoxic | HENKEL AG & CO. KGAA (DE) | 2007-11-15 | — | — | US | disclosed |
| US-7176177-B2 | Aromas and aroma compositions containing 4,8-dimethyl-3,7-nonadien-2-one, and a method for the production thereof | SYMRISE GMBH & CO. KG (DE) | 2007-02-13 | — | — | US | disclosed |
| US-20060029624-A1 | Low-residue deodorant or antiperspirant stick based on an oil-in-water dispersion | HENKEL AG & CO. KGAA (DE) | 2006-02-09 | — | — | US | disclosed |
| US-20030096731-A1 | Aromas and aroma compositions containing 4,8-dimethyl-3,7-nonadien-2-one, and a method for production thereof | SYMRISE AG (DE) | 2003-05-22 | — | — | US | disclosed |
| US-6566557-B2 | Oxidation of a phenylpropane compound | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-05-20 | — | — | US | disclosed |
| US-20020133045-A1 | Process for the preparation of substituted trans-cinnamaldehyde, a natural yellow dye, from phenylpropane derivatives | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2002-09-19 | — | — | US | disclosed |
| WO-2002072709-A1 | A PROCESS FOR THE PREPARATION OF SUBSTITUTED TRANS-CINNAMALDEHYDE, A NATURAL YELLOW DYE, FROM PHENYLPROPANE DERIVATIVES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096731-A1 | Aromas and aroma compositions containing 4,8-dimethyl-3,7-nonadien-2-one, and a method for production thereof | TAS2R8, TAS2R7, TAS2R40 | ALDH1A1 343/4885LMNA 491/4885TRPA1 218/4885 |
| US-20120270932-A1 | Personal Care Compositions with Improved Hyposensitivity | CUTA, DPM1, PIEZO1 | ALDH1A1 3452/4885LMNA 702/4885TRPA1 10/4885 |
| US-20150376546-A1 | TETRAHYDROFURAN DERIVATIVES AS FRAGRANCES | TRPA1, ADH5, SORD | ALDH1A1 29/4885LMNA 3266/4885TRPA1 1/4885 |
| US-10344247-B2 | Tetrahydrofuran derivatives as fragrances | TRPA1, ADH5, SORD | ALDH1A1 29/4885LMNA 3266/4885TRPA1 1/4885 |
| US-20020133045-A1 | Process for the preparation of substituted trans-cinnamaldehyde, a natural yellow dye, from phenylpropane derivatives | CBR3, DDT, DHODH | ALDH1A1 1048/4885LMNA 1783/4885TRPA1 630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.