SCHEMBL339622

SCHEMBL339622

CN(C)c1ccc2cc(-c3ccc(N4C(=O)C=CC4=O)cc3)oc2c1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.51
APAF1 O14727 1/20 0.51
USP2 O75604 1/20 0.51
RAB9A P51151 1/20 0.51
APP P05067 3/20 0.45
EP300 Q09472 1/20 0.44
SLC16A3 O15427 1/20 0.44
TNKS O95271 1/20 0.44
PGR P06401 4/20 0.43
QPCT Q16769 1/20 0.41
AR P10275 1/20 0.41
SHBG P04278 1/20 0.39
MAPT P10636 1/20 0.39
FAAH O00519 2/20 0.39
MGLL Q99685 2/20 0.39
CCNC P24863 1/20 0.38
CDK8 P49336 1/20 0.38
HDAC6 Q9UBN7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10777972 0.74 L3MBTL1 (0.56) L3MBTL1APAF1USP2RAB9AAPP
SCHEMBL3759716 0.73 MGLL (0.65) L3MBTL1MAPTFAAHMGLL
SCHEMBL339623 0.73 EP300 (0.39) L3MBTL1APPEP300PGRFAAH
SCHEMBL7750137 0.73 EP300 (0.78) L3MBTL1RAB9AEP300QPCTMAPT
SCHEMBL2207387 0.73 ALDH1A1 (0.40) RAB9ATNKSSHBGMAPTFAAH
SCHEMBL15080535 0.72 APP (0.57) L3MBTL1APAF1USP2RAB9AAPP
SCHEMBL14076002 0.71 APP (0.62) L3MBTL1APAF1USP2RAB9AAPP
SCHEMBL14075998 0.71 APP (0.58) L3MBTL1APAF1USP2RAB9AAPP
SCHEMBL25470835 0.70 APP (0.52) L3MBTL1APAF1USP2RAB9AAPP
SCHEMBL20468570 0.70 L3MBTL1 (0.66) L3MBTL1APAF1USP2RAB9AAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12638394-B2 Skin sensitization measuring reagent, method for measuring skin sensitization, and compound FUJIFILM CORPORATION (JP) 2026-05-26 US disclosed
EP-4036570-B1 REAGENT FOR MEASURING SKIN SENSITIZATION, METHOD FOR MEASURING SKIN SENSITIZATION, AND COMPOUND FUJIFILM CORP (JP) 2025-03-05 EP disclosed
EP-4234537-A1 REAGENT FOR MEASURING SKIN SENSITIZATION, COMPOUND, AND METHOD FOR MEASURING SKIN SENSITIZATION FUJIFILM Corporation (JP) 2023-08-30 EP disclosed
US-20230258569-A1 REAGENT FOR MEASURING SKIN SENSITIZATION, COMPOUND, AND METHOD FOR MEASURING SKIN SENSITIZATION FUJIFILM CORPORATION (JP) 2023-08-17 US disclosed
EP-4036570-A1 REAGENT FOR MEASURING SKIN SENSITIZATION, METHOD FOR MEASURING SKIN SENSITIZATION, AND COMPOUND FUJIFILM Corporation (JP) 2022-08-03 EP disclosed
US-20220214276-A1 SKIN SENSITIZATION MEASURING REAGENT, METHOD FOR MEASURING SKIN SENSITIZATION, AND COMPOUND FUJIFILM CORPORATION (JP) 2022-07-07 US disclosed
WO-2022085762-A1 REAGENT FOR MEASURING SKIN SENSITIZATION, COMPOUND, AND METHOD FOR MEASURING SKIN SENSITIZATION 富士フイルム株式会社 2022-04-28 WO disclosed
WO-2021060477-A1 REAGENT FOR MEASURING SKIN SENSITIZATION, METHOD FOR MEASURING SKIN SENSITIZATION, AND COMPOUND 富士フイルム株式会社 2021-04-01 WO disclosed
EP-1646395-B1 METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY CURIS INC (US) 2014-11-05 EP disclosed
US-8637562-B2 Methods for detecting sulfhydryl-containing compounds in a biological test sample THERAVANCE, INC. (US) 2014-01-28 US disclosed
EP-1036092-A2 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS BIOGEN, INC. (US) 2000-09-20 EP disclosed
EP-1028741-A1 REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO Ontogeny, Inc. (US) 2000-08-23 EP disclosed
WO-2000035948-A1 METHODS AND COMPOSITIONS FOR TREATING DISORDERS INVOLVING EXCITOTOXICITY BIOGEN, INC. (US) 2000-06-22 WO disclosed
EP-1009424-A2 REGULATION OF MUSCLE TISSUES BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO Ontogeny, Inc. (US) 2000-06-21 EP disclosed
WO-2000027422-A2 METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PERIPHERAL NEUROPATHIES BIOGEN, INC. (US) 2000-05-18 WO disclosed
WO-1999028343-A9 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS BIOGEN INC (US) 1999-10-14 WO disclosed
WO-1999028343-A2 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS BIOGEN, INC. (US) 1999-06-10 WO disclosed
WO-1999020298-A1 REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO ONTOGENY, INC. (US) 1999-04-29 WO disclosed
WO-1999010004-A2 REGULATION OF MUSCLE TISSUES BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO ONTOGENY, INC. (US) 1999-03-04 WO disclosed
US-5790627-A Method and apparatus for observing a specimen using an X-ray microscope RESEARCH DEVELOPMENT CORP. (JP) 1998-08-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12638394-B2 Skin sensitization measuring reagent, method for measuring skin sensitization, and compound HRH1, HRH4, CUTA L3MBTL1 3292/4885APAF1 4512/4885USP2 2523/4885
US-20230258569-A1 REAGENT FOR MEASURING SKIN SENSITIZATION, COMPOUND, AND METHOD FOR MEASURING SKIN SENSITIZATION TST, CUTA, HNMT L3MBTL1 4306/4885APAF1 4049/4885USP2 1275/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.