Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGDS | O60760 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23581884 | 0.85 | HTR2B (0.53) | ALDH1A1HPGDSHDAC6IRAK4ACHE | |
| Hydrochloric Acid SCHEMBL30862504 | 0.84 | HTR2B (0.51) | ALDH1A1HPGDSHDAC6IRAK4ACHE | |
| Hydrochloric Acid SCHEMBL30196166 | 0.84 | HTR2B (0.51) | ALDH1A1HPGDSHDAC6IRAK4ACHE | |
| SCHEMBL12571467 | 0.81 | MAOA (0.53) | ALDH1A1HPGDSHDAC6IRAK4ACHE | |
| Fumaric Acid SCHEMBL31258611 | 0.81 | HTR2B (0.46) | ALDH1A1HPGDSHDAC6IRAK4ACHE | |
| SCHEMBL657641 | 0.81 | ALDH1A1 (0.70) | ALDH1A1HPGDSKDM4EHDAC6PTPN1 | |
| SCHEMBL31351012 | 0.81 | HDAC6 (0.72) | ALDH1A1HPGDSKDM4EHDAC6IRAK4 | |
| SCHEMBL369871 | 0.81 | HDAC6 (0.72) | ALDH1A1HPGDSKDM4EHDAC6IRAK4 | |
| SCHEMBL352152 | 0.79 | HPGDS (0.73) | ALDH1A1HPGDSKDM4EHDAC6PTPN1 | |
| SCHEMBL3435162 | 0.78 | RAB9A (0.60) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025082460-A1 | DIACYLGLYCEROL KINASE INHIBITOR COMPOUND AND USE THEREOF | 上海先祥医药科技有限公司 | 2025-04-24 | — | — | WO | disclosed |
| CN-113365994-B | Pyridazinyl thiazole carboxamides | 安斯泰来制药株式会社 | 2024-08-09 | — | — | CN | disclosed |
| CN-115590854-B | Pyridazinyl thiazole carboxamides | 安斯泰来制药株式会社 | 2024-06-07 | — | — | CN | disclosed |
| CN-117534665-A | Diacylglycerol kinase inhibitors | 山东轩竹医药科技有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-117510497-A | DGK zeta inhibitors | 山东轩竹医药科技有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-115626919-A | Pyridazinyl thiazole carboxamides | 安斯泰来制药株式会社 | 2023-01-20 | — | — | CN | disclosed |
| CN-115590854-A | Pyridazinyl thiazole carboxamides | 安斯泰来制药株式会社（JP） | 2023-01-13 | — | — | CN | disclosed |
| US-20220315603-A1 | PYRIDAZINYL-THIAZOLECARBOXAMIDE COMPOUND | KOTOBUKI PHARMACEUTICAL CO., LTD. (JP) | 2022-10-06 | — | — | US | disclosed |
| CN-113365994-A | Pyridazinyl thiazole carboxamides | 安斯泰来制药株式会社 | 2021-09-07 | — | — | CN | disclosed |
| WO-2021132422-A1 | PYRIDAZINYL THIAZOLECARBOXAMIDE COMPOUND | アステラス製薬株式会社 | 2021-07-01 | — | — | WO | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-20090118503-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. | 2009-05-07 | — | — | US | disclosed |
| US-20090118503-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. | 2009-05-07 | — | — | US | disclosed |
| WO-2008054702-A1 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197708-A1 | INDOLE COMPOUNDS | IDO1, IDO2, TPH2 | ALDH1A1 1229/4885HPGDS 141/4885KDM4E 2243/4885 |
| US-20220315603-A1 | PYRIDAZINYL-THIAZOLECARBOXAMIDE COMPOUND | CD274, PDCD1, PDCD1LG2 | ALDH1A1 1416/4885HPGDS 891/4885KDM4E 1077/4885 |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | ALDH1A1 178/4885HPGDS 267/4885KDM4E 2232/4885 |
| US-20090118503-A1 | FAAH INHIBITORS | FAAH, FAAH2, CNR2 | ALDH1A1 648/4885HPGDS 139/4885KDM4E 1921/4885 |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | GPR17, NTRK1, TRPV1 | ALDH1A1 975/4885HPGDS 2971/4885KDM4E 1834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.