Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 10/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3491520 | 0.87 | PKM (0.54) | PKMMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL8107611 | 0.85 | MAPT (0.60) | PKMMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL3489700 | 0.84 | PKM (0.54) | PKMMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL3491523 | 0.84 | PKM (0.57) | PKMMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL891444 | 0.82 | MAPT (0.55) | PKMMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL8147273 | 0.82 | MAPT (0.65) | PKMMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6745448 | 0.79 | MAPT (0.59) | PKMMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL502704 | 0.79 | KAT2B (0.58) | PKMMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL14063303 | 0.79 | HCAR3 (0.65) | PKMMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL29375013 | 0.79 | KAT2B (0.58) | PKMMAPTPOLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650672-B2 | Enzymes resistant to photodamage | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2017-05-16 | — | — | US | disclosed |
| US-20160017413-A1 | ENZYMES RESISTANT TO PHOTODAMAGE | PACIFIC BIOSCIENCES CALIFORNIA (US) | 2016-01-21 | — | — | US | disclosed |
| US-9127259-B2 | Enzymes resistant to photodamage | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-20100093555-A1 | Enzymes resistant to photodamage | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093555-A1 | Enzymes resistant to photodamage | POLB, POLN, POLM | PKM 2203/4885MAPT 2398/4885POLB 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.