Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 3/20 | 0.40 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.39 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.39 |
| ▸ | CA4 known ✓ | P22748 | 2/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL10800058 | 0.91 | FFAR3 (0.42) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Acetic Acid SCHEMBL10800052 | 0.91 | FFAR3 (0.42) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL28668393 | 0.84 | CA1 (0.48) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL17873523 | 0.80 | CA1 (0.44) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL27449071 | 0.79 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2526702 | 0.79 | APP (0.44) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2516912 | 0.79 | APP (0.44) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3563113 | 0.78 | FFAR3 (0.43) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL28245794 | 0.75 | CA1 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL27864686 | 0.74 | CA1 (0.47) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662854-B2 | HIF hydroxylase inhibitors | ISIS INNOVATION LIMITED (GB) | 2010-02-16 | — | — | US | disclosed |
| US-7638295-B2 | Identifying agent which modulates 2-oxoglutarate dependent oxygenase; ankyrin substrate; hypoxia-inducible factor; thalassemia | ISIS INNOVATION LIMITED (GB) | 2009-12-29 | — | — | US | disclosed |
| EP-2065366-A2 | HIF hydroxylase inhibitors | ISIS Innovation Limited (GB) | 2009-06-03 | — | — | EP | disclosed |
| EP-1485347-B1 | HIF HYDROXYLASE INHIBITORS FOR USE IN THE TREATMENT OF ANAEMIA | ISIS INNOVATION (GB) | 2009-04-29 | — | — | EP | disclosed |
| US-20080227848-A1 | Assays | ISIS INNOVATION LIMITED (GB) | 2008-09-18 | — | — | US | disclosed |
| EP-1466927-B1 | PROCESS FOR PRODUCTION OF CARBOXYLIC ACID POLYMERS | KAO CORP (JP) | 2007-03-28 | — | — | EP | disclosed |
| US-20070066576-A1 | HIF hydroxylase inhibitors | ISIS INNOVATION LIMITED (GB) | 2007-03-22 | — | — | US | disclosed |
| EP-1733030-A2 | ASSAYS FOR IDENTIFYING MODULATORS OF THE HYDROXYLATION OF ANKYRIN REPEAT PROTEINS BY 2-OXOGLUTARATE DEPENDENT OXYGENASE AND METHODS OF USING THE SAME | ISIS INNOVATION LIMITED (GB) | 2006-12-20 | — | — | EP | disclosed |
| US-20050227948-A1 | Hif hydroxylase inhibitors | ISIS INNOVATION LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
| WO-2005093411-A2 | ASSAYS FOR IDENTIFYING MODULATORS OF THE HYDROXYLATION OF ANKYRIN REPEAT PROTEINS BY 2-OXOGLUTARATE DEPENDENT OXIGENASE AND METHODS OF USING THE SAME | ISIS INNOVATION LIMITED (GB) | 2005-10-06 | — | — | WO | disclosed |
| EP-1485347-A2 | HIF HYDROXYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2004-12-15 | — | — | EP | disclosed |
| EP-1466927-A1 | PROCESS FOR PRODUCTION OF CARBOXYLIC ACID POLYMERS | Kao Corporation (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003080566-A2 | HIF HYDROXYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227948-A1 | Hif hydroxylase inhibitors | HIF1AN, HIF1A, EGLN3 | CA1 1222/4885PTGS1 84/4885PDE4A 1069/4885 |
| US-20070066576-A1 | HIF hydroxylase inhibitors | HIF1AN, HIF1A, EGLN3 | CA1 1222/4885PTGS1 84/4885PDE4A 1069/4885 |
| US-20080227848-A1 | Assays | OGDH, HOGA1, OXGR1 | CA1 3246/4885PTGS1 1167/4885PDE4A 4615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.