Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 3/20 | 0.40 |
| ▸ | CA4 known ✓ | P22748 | 2/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zinc Ion SCHEMBL8372146 | 0.94 | FFAR3 (0.39) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Lithium Ion SCHEMBL2524489 | 0.84 | CA1 (0.42) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL5022357 | 0.84 | CA1 (0.48) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL16719246 | 0.80 | CA1 (0.44) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3645966 | 0.80 | CA1 (0.44) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL27989388 | 0.78 | APEX1 (0.57) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3563111 | 0.78 | FFAR3 (0.43) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL9421241 | 0.77 | HDAC3 (0.48) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL11335835 | 0.76 | ALDH1A1 (0.44) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| SCHEMBL29398624 | 0.76 | ALDH1A1 (0.45) | KDM4EMAPTALOX15CA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662854-B2 | HIF hydroxylase inhibitors | ISIS INNOVATION LIMITED (GB) | 2010-02-16 | — | — | US | disclosed |
| US-7638295-B2 | Identifying agent which modulates 2-oxoglutarate dependent oxygenase; ankyrin substrate; hypoxia-inducible factor; thalassemia | ISIS INNOVATION LIMITED (GB) | 2009-12-29 | — | — | US | disclosed |
| EP-2065366-A2 | HIF hydroxylase inhibitors | ISIS Innovation Limited (GB) | 2009-06-03 | — | — | EP | disclosed |
| EP-1485347-B1 | HIF HYDROXYLASE INHIBITORS FOR USE IN THE TREATMENT OF ANAEMIA | ISIS INNOVATION (GB) | 2009-04-29 | — | — | EP | disclosed |
| US-20080227848-A1 | Assays | ISIS INNOVATION LIMITED (GB) | 2008-09-18 | — | — | US | disclosed |
| EP-1466927-B1 | PROCESS FOR PRODUCTION OF CARBOXYLIC ACID POLYMERS | KAO CORP (JP) | 2007-03-28 | — | — | EP | disclosed |
| US-20070066576-A1 | HIF hydroxylase inhibitors | ISIS INNOVATION LIMITED (GB) | 2007-03-22 | — | — | US | disclosed |
| EP-1733030-A2 | ASSAYS FOR IDENTIFYING MODULATORS OF THE HYDROXYLATION OF ANKYRIN REPEAT PROTEINS BY 2-OXOGLUTARATE DEPENDENT OXYGENASE AND METHODS OF USING THE SAME | ISIS INNOVATION LIMITED (GB) | 2006-12-20 | — | — | EP | disclosed |
| US-20050227948-A1 | Hif hydroxylase inhibitors | ISIS INNOVATION LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
| WO-2005093411-A2 | ASSAYS FOR IDENTIFYING MODULATORS OF THE HYDROXYLATION OF ANKYRIN REPEAT PROTEINS BY 2-OXOGLUTARATE DEPENDENT OXIGENASE AND METHODS OF USING THE SAME | ISIS INNOVATION LIMITED (GB) | 2005-10-06 | — | — | WO | disclosed |
| EP-1485347-A2 | HIF HYDROXYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2004-12-15 | — | — | EP | disclosed |
| EP-1466927-A1 | PROCESS FOR PRODUCTION OF CARBOXYLIC ACID POLYMERS | Kao Corporation (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003080566-A2 | HIF HYDROXYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227948-A1 | Hif hydroxylase inhibitors | HIF1AN, HIF1A, EGLN3 | CA1 1222/4885CA4 311/4885FFAR3 2487/4885 |
| US-20070066576-A1 | HIF hydroxylase inhibitors | HIF1AN, HIF1A, EGLN3 | CA1 1222/4885CA4 311/4885FFAR3 2487/4885 |
| US-20080227848-A1 | Assays | OGDH, HOGA1, OXGR1 | CA1 3246/4885CA4 4106/4885FFAR3 4611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.