SCHEMBL358066

SCHEMBL358066

O=C(Nc1ccccc1Nc1ccccc1)c1ccccc1Br

nearest known ligand 0.72

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.72
MEN1 O00255 5/20 0.72
SMN1; SMN2 Q16637 2/20 0.57
NPC1 O15118 2/20 0.57
RAB9A P51151 2/20 0.57
FABP4 P15090 1/20 0.56
TDP1 Q9NUW8 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
RXFP1 Q9HBX9 1/20 0.54
MAPT P10636 2/20 0.52
USP2 O75604 1/20 0.51
F2R P25116 2/20 0.50
TP53 P04637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28695522 0.83 KMT2A (0.70) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL882734 0.83 KMT2A (0.80) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL6426650 0.81 KMT2A (0.69) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL10070482 0.81 FABP4 (0.56) KMT2AMEN1NPC1RAB9AFABP4
SCHEMBL6140750 0.78 SIRT2 (0.59) KMT2AMEN1NPC1RAB9AFABP4
SCHEMBL339194 0.77 MEN1 (0.71) KMT2AMEN1NPC1RAB9ATDP1
SCHEMBL12076664 0.77 MEN1 (0.58) KMT2AMEN1SMN1; SMN2RAB9AFABP4
SCHEMBL14363396 0.77 ALDH1A1 (0.61) KMT2AMEN1NPC1RAB9AL3MBTL1
SCHEMBL31092076 0.77 HPGD (0.68) KMT2AMEN1SMN1; SMN2NPC1RAB9A
SCHEMBL15770775 0.76 MEN1 (0.53) KMT2AMEN1FABP4MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2477979-B1 COMPOUNDS FOR ORGANIC LIGHT EMITTING DIODE EMISSIVE LAYERS NITTO DENKO CORP (JP) 2016-10-26 EP disclosed
US-8808879-B2 Phototherapy devices and methods comprising substituted carbazole compounds NITTO DENKO CORPORATION (JP) 2014-08-19 US disclosed
US-8808879-B2 Phototherapy devices and methods comprising substituted carbazole compounds NITTO DENKO CORPORATION (JP) 2014-08-19 US disclosed
US-8808879-B2 Phototherapy devices and methods comprising substituted carbazole compounds NITTO DENKO CORPORATION (JP) 2014-08-19 US disclosed
US-8586205-B2 Compounds for organic light emitting diode emissive layers NITTO DENKO CORPORATION (JP) 2013-11-19 US disclosed
US-8586205-B2 Compounds for organic light emitting diode emissive layers NITTO DENKO CORPORATION (JP) 2013-11-19 US disclosed
EP-2477979-A1 COMPOUNDS FOR ORGANIC LIGHT EMITTING DIODE EMISSIVE LAYERS Nitto Denko Corporation (JP) 2012-07-25 EP disclosed
WO-2012012295-A1 PHOTOTHERAPY DEVICES AND METHODS COMPRISING SUBSTITUTED CARBAZOLE COMPOUNDS NITTO DENKO CORPORATION (JP) 2012-01-26 WO disclosed
WO-2012012295-A1 PHOTOTHERAPY DEVICES AND METHODS COMPRISING SUBSTITUTED CARBAZOLE COMPOUNDS NITTO DENKO CORPORATION (JP) 2012-01-26 WO disclosed
US-20120016449-A1 PHOTOTHERAPY DEVICES AND METHODS COMPRISING SUBSTITUTED CARBAZOLE COMPOUNDS NITTO DENKO CORPORATION (JP) 2012-01-19 US disclosed
US-20120016449-A1 PHOTOTHERAPY DEVICES AND METHODS COMPRISING SUBSTITUTED CARBAZOLE COMPOUNDS NITTO DENKO CORPORATION (JP) 2012-01-19 US disclosed
WO-2011034967-A1 COMPOUNDS FOR ORGANIC LIGHT EMITTING DIODE EMISSIVE LAYERS NITTO DENKO CORPORATION (JP) 2011-03-24 WO disclosed
WO-2011034967-A1 COMPOUNDS FOR ORGANIC LIGHT EMITTING DIODE EMISSIVE LAYERS NITTO DENKO CORPORATION (JP) 2011-03-24 WO disclosed
US-20110062386-A1 COMPOUNDS FOR ORGANIC LIGHT EMITTING DIODE EMISSIVE LAYERS NITTO DENKO CORPORATION (JP) 2011-03-17 US disclosed
US-20110062386-A1 COMPOUNDS FOR ORGANIC LIGHT EMITTING DIODE EMISSIVE LAYERS NITTO DENKO CORPORATION (JP) 2011-03-17 US disclosed
US-20110062386-A1 COMPOUNDS FOR ORGANIC LIGHT EMITTING DIODE EMISSIVE LAYERS NITTO DENKO CORPORATION (JP) 2011-03-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120016449-A1 PHOTOTHERAPY DEVICES AND METHODS COMPRISING SUBSTITUTED CARBAZOLE COMPOUNDS TYR, PPOX, CRY1 KMT2A 710/4885MEN1 2684/4885SMN1; SMN2 1851/4885
US-20110062386-A1 COMPOUNDS FOR ORGANIC LIGHT EMITTING DIODE EMISSIVE LAYERS ALOX12, ALOX15B, ALOX15 KMT2A 1816/4885MEN1 1773/4885SMN1; SMN2 4267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.