Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 4/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 5/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670285 | 0.90 | TRPV4 (0.43) | HSD17B1HSD17B2TRPV4TACR1MLYCD | |
| SCHEMBL3671611 | 0.88 | PDK1 (0.54) | HSD17B1HSD17B2PDK1TACR1MLYCD | |
| SCHEMBL1950917 | 0.85 | PTGDR2 (0.54) | TRPV4 | |
| SCHEMBL3671698 | 0.80 | NAMPT (0.53) | HSD17B1HSD17B2KMT2A | |
| SCHEMBL3671609 | 0.78 | MLYCD (0.52) | HSD17B1HSD17B2PDK1TACR1MLYCD | |
| SCHEMBL3668574 | 0.77 | GPBAR1 (0.52) | TRPV4TACR1GPBAR1 | |
| SCHEMBL3667571 | 0.76 | MGLL (0.42) | HSD17B1HSD17B2PDK1TACR1MEN1 | |
| SCHEMBL3666332 | 0.76 | MTOR (0.47) | TACR1MGLLBRAF | |
| SCHEMBL3671902 | 0.76 | LIPE (0.46) | PDK1TACR1MGLLBRAF | |
| SCHEMBL3666876 | 0.75 | ABHD6 (0.54) | HSD17B2PDK1TACR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240434-A1 | 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS | Ligand Pharmaceuticals Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009089192-A1 | 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS | LIGAND PHARMACEUTICALS INC. (US) | 2009-07-16 | — | — | WO | disclosed |