Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 3/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673329 | 0.94 | FFAR4 (0.61) | CALM1APPTSHRHDAC1HDAC2 | |
| SCHEMBL7995941 | 0.93 | FFAR4 (0.60) | CALM1APPTSHRHDAC1HDAC2 | |
| SCHEMBL2840795 | 0.92 | FFAR4 (0.55) | CALM1APPHDAC1HDAC2FFAR4 | |
| SCHEMBL347209 | 0.89 | FFAR4 (0.61) | FFAR4FFAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL3693650 | 0.88 | LMNA (0.60) | APPHDAC1HDAC2FFAR4FFAR1 | |
| SCHEMBL22622262 | 0.88 | LMNA (0.62) | APPHDAC1HDAC2FFAR4FFAR1 | |
| SCHEMBL1269702 | 0.88 | PPARG (0.53) | CALM1APPTSHRHDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL3225386 | 0.87 | FFAR4 (0.59) | FFAR4FFAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL9178046 | 0.87 | FFAR4 (0.55) | APPFFAR4FFAR1PPARAALDH1A1 | |
| SCHEMBL5687906 | 0.85 | PPARA (0.57) | APPHDAC1HDAC2FFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795310-B2 | Methods and reagents for the treatment of metabolic disorders | COMBINATORX, INC. (US) | 2010-09-14 | — | — | US | disclosed |
| EP-1781303-A4 | METHODS AND REAGENTS FOR THE TREATMENT OF METABOLIC DISORDERS | COMBINATORX INC (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1781303-A1 | METHODS AND REAGENTS FOR THE TREATMENT OF METABOLIC DISORDERS | CombinatoRx, Incorporated (US) | 2007-05-09 | — | — | EP | disclosed |
| US-20060122064-A1 | Amides and method for plant diseases control with the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-06-08 | — | — | US | disclosed |
| US-20060069161-A1 | Methods and reagents for the treatment of metabolic disorders | COMBINATORX, INC. (US) | 2006-03-30 | — | — | US | disclosed |
| EP-1640360-A1 | AMIDES AND METHOD FOR PLANT DISEASE CONTROL WITH THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-03-29 | — | — | EP | disclosed |
| WO-2006004803-A1 | METHODS AND REAGENTS FOR THE TREATMENT OF METABOLIC DISORDERS | COMBINATORX, INCORPORATED (US) | 2006-01-12 | — | — | WO | disclosed |
| WO-2005122766-A1 | FUNGICIDAL COMPOSITION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-12-29 | — | — | WO | disclosed |
| EP-1609360-A1 | Fungicidal Composition | Sumitomo Chemical Company, Limited (JP) | 2005-12-28 | — | — | EP | disclosed |
| US-20050282888-A1 | Fungicidal composition | SUMITOMO CHEMICAL COMPANY, LIMITED | 2005-12-22 | — | — | US | disclosed |
| US-4026896-A | ANTIALLERGENS | KISSEI YAKUHIN KOGYO KABUSHIKI KAISHA (KISSEI PHARMACEUTICAL CO. LTD.) (JA) | 1977-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122064-A1 | Amides and method for plant diseases control with the same | ARG1, ARGLU1, ARG2 | CALM1 1314/4885APP 3090/4885TSHR 851/4885 |
| US-20050282888-A1 | Fungicidal composition | DDT, CYP51A1, DDAH1 | CALM1 1995/4885APP 2172/4885TSHR 3635/4885 |
| US-20060069161-A1 | Methods and reagents for the treatment of metabolic disorders | LIPC, PNLIP, GOT2 | CALM1 3616/4885APP 2382/4885TSHR 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.