Sugi Predict

Sugi Predict / Compounds / SCHEMBL3717062

SCHEMBL3717062

SCHEMBL3717062

CCOC(=O)c1nnc(-c2ccccn2)s1

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.63
▸ KDM4E B2RXH2 9/20 0.53
▸ HSD17B10 Q99714 6/20 0.53
▸ SMN1; SMN2 Q16637 4/20 0.53
▸ HPGD P15428 2/20 0.53
▸ RAB9A P51151 6/20 0.53
▸ NPC1 O15118 4/20 0.53
▸ MAPT P10636 2/20 0.53
▸ ATM Q13315 1/20 0.53
▸ FAAH O00519 1/20 0.52
▸ CES1 P23141 1/20 0.52
▸ ALDH1A1 P00352 4/20 0.50
▸ TP53 P04637 1/20 0.47
▸ CASP1 P29466 1/20 0.46
▸ KMT2A Q03164 3/20 0.46
▸ P2RY1 P47900 1/20 0.45
▸ GAA P10253 1/20 0.44
▸ MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30839468 1.00 LMNA (0.63) LMNAKDM4EHSD17B10SMN1; SMN2HPGD
SCHEMBL2161780 0.85 KDM4E (0.57) LMNAKDM4EHSD17B10SMN1; SMN2HPGD
SCHEMBL26524124 0.84 FAAH (0.59) LMNAKDM4EHSD17B10SMN1; SMN2HPGD
SCHEMBL3725911 0.83 LMNA (0.45) LMNAKDM4EHSD17B10SMN1; SMN2HPGD
SCHEMBL22619842 0.83 CDC7 (0.47) LMNACASP1P2RY1
SCHEMBL22617532 0.81 KDM4E (0.46) LMNAKDM4EMAPTCES1ALDH1A1
SCHEMBL22617530 0.81 CDC7 (0.63) LMNAKDM4EHSD17B10SMN1; SMN2HPGD
SCHEMBL9905494 0.81 KDM4E (0.65) LMNAKDM4EHSD17B10SMN1; SMN2HPGD
SCHEMBL2179717 0.80 TRPM8 (0.58) LMNAKDM4EHSD17B10SMN1; SMN2HPGD
SCHEMBL22617519 0.80 P2RY1 (0.44) LMNAKDM4ESMN1; SMN2RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12325702-B2 ATF6 inhibitors and uses thereof ALTOS LABS, INC. (US) 2025-06-10 — — US disclosed
US-20240124434-A1 ATF6 INHIBITORS AND USES THEREOF ALTOS LABS, INC. 2024-04-18 — — US disclosed
EP-3388428-B1 FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR SUZHOU SINOVENT PHARMACEUTICALS COMPANY (CN) 2021-08-04 — — EP disclosed
US-20210221803-A1 ATF6 INHIBITORS AND USES THEREOF ALTOS LABS, INC. 2021-07-22 — — US disclosed
US-20210221803-A1 ATF6 INHIBITORS AND USES THEREOF ALTOS LABS, INC. 2021-07-22 — — US disclosed
EP-3774782-A2 ATF6 INHIBITORS AND USES THEREOF Black Belt TX Ltd (GB) 2021-02-17 — — EP disclosed
CN-112313224-A ATF6 inhibitors and uses thereof 黑带医疗有限责任公司 2021-02-02 — — CN disclosed
US-10829485-B2 ATF6 inhibitors and uses thereof BLACK BELT TX LTD (GB) 2020-11-10 — — US disclosed
US-10829485-B2 ATF6 inhibitors and uses thereof BLACK BELT TX LTD (GB) 2020-11-10 — — US disclosed
US-10821104-B2 Five-membered heterocyclic amides WNT pathway inhibitor Suzhou Sinovent Pharmaceuticals Co., Ltd. (CN) 2020-11-03 — — US disclosed
CN-102459296-B ketolide compounds having antimicrobial activity WOCKHARDT RESEARCH CENTRE (IN) 2014-10-29 — — CN disclosed
US-20140005133-A1 KETOLIDE COMPOUNDS WOCKHARDT LIMITED (IN) 2014-01-02 — — US disclosed
EP-2673285-A1 KETOLIDE COMPOUNDS Wockhardt Limited (IN) 2013-12-18 — — EP disclosed
US-8541420-B2 Ketolide compounds having antimicrobial activity WOCKHARDT LTD. (IN) 2013-09-24 — — US disclosed
US-8541420-B2 Ketolide compounds having antimicrobial activity WOCKHARDT LTD. (IN) 2013-09-24 — — US disclosed
WO-2012076989-A1 KETOLIDE COMPOUNDS WOCKHARDT LIMITED (IN) 2012-06-14 — — WO disclosed
US-20120142710-A1 Ketolide Compounds Having Antimicrobial Activity WOCKHARDT LIMITED (IN) 2012-06-07 — — US disclosed
US-20120142710-A1 Ketolide Compounds Having Antimicrobial Activity WOCKHARDT LIMITED (IN) 2012-06-07 — — US disclosed
CN-102459296-A Ketolide compounds with antimicrobial activity WOCKHARDT RESEARCH CENTER 2012-05-16 — — CN disclosed
WO-2010136971-A1 KETOLIDE COMPOUNDS HAVING ANTIMICROBIAL ACTIVITY WOCKHARDT RESEARCH CENTRE (IN) 2010-12-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124434-A1 ATF6 INHIBITORS AND USES THEREOF ATF4, XBP1, ATF1 LMNA 2920/4885KDM4E 4305/4885HSD17B10 2671/4885
US-12325702-B2 ATF6 inhibitors and uses thereof ATF4, XBP1, ATF1 LMNA 2920/4885KDM4E 4305/4885HSD17B10 2671/4885
US-10821104-B2 Five-membered heterocyclic amides WNT pathway inhibitor WNT1, WNT3, WNT3A LMNA 3903/4885KDM4E 1435/4885HSD17B10 1808/4885
US-20120142710-A1 Ketolide Compounds Having Antimicrobial Activity CYP51A1, AKR1A1, AKR1C1 LMNA 3964/4885KDM4E 128/4885HSD17B10 180/4885
US-10829485-B2 ATF6 inhibitors and uses thereof ATF4, XBP1, ATF1 LMNA 2920/4885KDM4E 4305/4885HSD17B10 2671/4885
US-20210221803-A1 ATF6 INHIBITORS AND USES THEREOF ATF4, XBP1, ATF1 LMNA 2920/4885KDM4E 4305/4885HSD17B10 2671/4885
US-20140005133-A1 KETOLIDE COMPOUNDS AKR1C3, AKR1D1, AKR1C1 LMNA 4118/4885KDM4E 298/4885HSD17B10 325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.