Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2046093 | 0.75 | CPT1A (0.33) | CPT1A | |
| SCHEMBL2047432 | 0.75 | CPT1A (0.33) | CPT1A | |
| SCHEMBL2051800 | 0.75 | MMP9 (0.36) | CPT1AMMP9ALDH1A1 | |
| Allobarbital SCHEMBL11484021 | 0.71 | LMNA (0.46) | CPT1AMMP9ALDH1A1 | |
| SCHEMBL2047416 | 0.71 | CPT1A (0.34) | CPT1ACYP3A4MMP9PGR | |
| SCHEMBL2050365 | 0.71 | CPT1A (0.31) | CPT1A | |
| SCHEMBL5065701 | 0.71 | ALDH1A1 (0.43) | CPT1ACYP3A4MMP9ALDH1A1 | |
| SCHEMBL2045943 | 0.71 | CPT1A (0.31) | CPT1A | |
| SCHEMBL13969137 | 0.70 | CPT1A (0.55) | CPT1A | |
| SCHEMBL2045917 | 0.69 | ALDH1A1 (0.32) | CPT1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420868-B2 | Process for the preparation of 2,2,4,4-tetraalkylcyclobutane-1,3-diols | EASTMAN CHEMICAL COMPANY (US) | 2013-04-16 | — | — | US | claimed |
| US-8420869-B2 | Process for the preparation of 2,2,4,4-tetraalkylcyclobutane-1,3-diols | EASTMAN CHEMICAL COMPANY (US) | 2013-04-16 | — | — | US | claimed |
| US-20120149946-A1 | PROCESS FOR THE PREPARATION OF 2,2,4,4-TETRAALKYLCYCLOBUTANE-1,3-DIOLS | EASTMAN CHEMICAL COMPANY (US) | 2012-06-14 | — | — | US | claimed |
| WO-2012078384-A1 | PROCESS FOR THE PREPARATION OF 2,2,4,4-TETRAALKYLCYCLOBUTANE-1,3-DIOLS | EASTMAN CHEMICAL COMPANY (US) | 2012-06-14 | — | — | WO | claimed |
| US-20120149947-A1 | PROCESS FOR THE PREPARATION OF 2,2,4,4-TETRAALKYLCYCLOBUTANE-1,3-DIOLS | EASTMAN CHEMICAL COMPANY (US) | 2012-06-14 | — | — | US | claimed |
| US-7838707-B2 | for a specific cis:trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters; hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione from the pyrolysis of isobutyric anhydride and dimerization of the resulting dimethylketene | EASTMAN CHEMICAL COMPANY (US) | 2010-11-23 | — | — | US | claimed |
| US-7582804-B2 | by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione; cesium and cobalt promoters; specific cis/trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters | EASTMAN CHEMICAL COMPANY (US) | 2009-09-01 | — | — | US | claimed |
| US-7560600-B2 | by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione in the presence of an zirconium-promoted nickel-based catalyst; specific cis/trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters | EASTMAN CHEMICAL COMPANY (US) | 2009-07-14 | — | — | US | claimed |
| US-7524994-B2 | by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione; specific cis/trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters | EASTMAN CHEMICAL COMPANY (US) | 2009-04-28 | — | — | US | claimed |
| US-7521583-B2 | Process for the preparation of tetraalkylcyclobutane-1,3-diol in the presence of a cobalt-based catalyst | EASTMAN CHEMICAL COMPANY (US) | 2009-04-21 | — | — | US | claimed |
| US-20080154069-A1 | for a specific cis:trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters; hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione from the pyrolysis of isobutyric anhydride and dimerization of the resulting dimethylketene | EASTMAN CHEMICAL COMPANY (US) | 2008-06-26 | — | — | US | claimed |
| US-20080132742-A1 | by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione; cesium and cobalt promoters; specific cis/trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters | EASTMAN CHEMICAL COMPANY (US) | 2008-06-05 | — | — | US | claimed |
| US-20080132738-A1 | by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione in the presence of an zirconium-promoted nickel-based catalyst; specific cis/trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters | EASTMAN CHEMICAL COMPANY (US) | 2008-06-05 | — | — | US | claimed |
| US-20080132737-A1 | by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione; specific cis/trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters | EASTMAN CHEMICAL COMPANY (US) | 2008-06-05 | — | — | US | claimed |
| US-20080132739-A1 | PROCESS FOR THE PREPARATION OF TETRAALKYLCYCLOBUTANE-1,3-DIOL IN THE PRESENCE OF A COBALT-BASED CATALYST | EASTMAN CHEMICAL COMPANY (US) | 2008-06-05 | — | — | US | claimed |
| US-5886223-A | REACTING A SUBSTITUTED ANILINE COMPOUND WITH A TETRAALKYL-1,3-CYCLOBUTANEDIONE COMPOUND AND A BASE IN THE PRESENCE OF A SOLVENT | AMERICAN CYANAMID COMPANY (US) | 1999-03-23 | — | — | US | claimed |
| JP-2305816-A | — | — | None | — | — | JP | disclosed |
| CN-114349596-A | Synthetic method of 2,2,4, 4-tetraalkyl-1, 3-cyclobutanediol | 万华化学集团股份有限公司 | 2022-04-15 | — | — | CN | disclosed |
| US-5886223-A | REACTING A SUBSTITUTED ANILINE COMPOUND WITH A TETRAALKYL-1,3-CYCLOBUTANEDIONE COMPOUND AND A BASE IN THE PRESENCE OF A SOLVENT | AMERICAN CYANAMID COMPANY (US) | 1999-03-23 | — | — | US | disclosed |
| JP-H02305816-A | OXYGEN-PERMEABLE MOLDING | KURARAY CO LTD | 1990-12-19 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149946-A1 | PROCESS FOR THE PREPARATION OF 2,2,4,4-TETRAALKYLCYCLOBUTANE-1,3-DIOLS | TELO2, TTI2, HAO2 | CPT1A 1897/4885CYP3A4 401/4885MMP9 4413/4885 |
| US-20080132739-A1 | PROCESS FOR THE PREPARATION OF TETRAALKYLCYCLOBUTANE-1,3-DIOL IN THE PRESENCE OF A COBALT-BASED CATALYST | TET1, TET3, HPD | CPT1A 884/4885CYP3A4 902/4885MMP9 3783/4885 |
| US-20080132738-A1 | by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione in the presence of an zirconium-promoted nickel-based catalyst; specific cis/trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters | ZRANB2, RCC1, TELO2 | CPT1A 1963/4885CYP3A4 1506/4885MMP9 3976/4885 |
| US-20080132742-A1 | by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione; cesium and cobalt promoters; specific cis/trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters | CA3, TELO2, CA1 | CPT1A 1847/4885CYP3A4 963/4885MMP9 3602/4885 |
| US-20120149947-A1 | PROCESS FOR THE PREPARATION OF 2,2,4,4-TETRAALKYLCYCLOBUTANE-1,3-DIOLS | DEGS1, ADH1C, HVCN1 | CPT1A 1199/4885CYP3A4 98/4885MMP9 4401/4885 |
| US-20080154069-A1 | for a specific cis:trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters; hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione from the pyrolysis of isobutyric anhydride and dimerization of the resulting dimethylketene | CA3, CA1, CA2 | CPT1A 796/4885CYP3A4 645/4885MMP9 4630/4885 |
| US-20080132737-A1 | by hydrogenation of a 2,2,4,4-tetraalkylcyclobutane-1,3-dione; specific cis/trans isomer ratio in order to control glass transition temperatures and/or crystallization rates in copolyesters | TELO2, CA3, CA1 | CPT1A 1520/4885CYP3A4 1267/4885MMP9 4413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.