SCHEMBL3775432

SCHEMBL3775432

O=C(O)c1cc2c(cc1C(=O)O)C(c1ccccc1)(c1ccc(F)c(F)c1F)c1cc(C(=O)O)c(C(=O)O)cc1O2

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 2/20 0.34
ALOX5 P09917 2/20 0.33
MAP2K1 Q02750 2/20 0.32
HCAR2 Q8TDS4 2/20 0.32
HCAR3 P49019 1/20 0.32
MAP2K2 P36507 1/20 0.32
AKR1C2 P52895 1/20 0.32
AKR1C1 Q04828 1/20 0.32
CYP2C9 P11712 1/20 0.32
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
ALDH1A1 P00352 1/20 0.30
HSD17B10 Q99714 1/20 0.30
LMNA P02545 1/20 0.30
ACMSD Q8TDX5 1/20 0.30
MEN1 O00255 1/20 0.30
POLB P06746 1/20 0.30
CASP6 P55212 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3770445 0.91 CES2 (0.36) ALOX5MAP2K1HCAR2HCAR3MAP2K2
SCHEMBL3274334 0.83 ALOX5 (0.41) CNR1ALOX5CYP2C9ALDH1A1HSD17B10
SCHEMBL21436917 0.73 ALOX5 (0.36) ALOX5CYP2C9ALDH1A1HSD17B10
SCHEMBL3271333 0.72 ALOX5 (0.39) CNR1ALOX5HCAR2HCAR3CYP2C9
SCHEMBL8984589 0.72 TDP1 (0.41) ALOX5CYP2C9ALDH1A1HSD17B10LMNA
SCHEMBL1099586 0.71 PDK2 (0.38) CNR1ALOX5CYP2C9NPC1RAB9A
SCHEMBL9221863 0.70 PDK2 (0.37) CNR1ALOX5CYP2C9NPC1RAB9A
SCHEMBL9220689 0.69 ALOX5 (0.35) CNR1ALOX5CYP2C9NPC1RAB9A
SCHEMBL9220858 0.69 PDK2 (0.36) CNR1ALOX5HCAR2HCAR3CYP2C9
SCHEMBL3277451 0.68 RAB9A (0.45) NPC1RAB9AALDH1A1HSD17B10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7851121-B2 Photosensitive polyimide composition and polyimide precursor composition CENTRAL GLASS CO., LTD. (JP) 2010-12-14 US disclosed
US-20090176172-A1 PHOTOSENSITIVE POLYIMIDE COMPOSITION AND POLYIMIDE PRECURSOR COMPOSITION CENTRAL GLASS CO., LTD. (JP) 2009-07-09 US disclosed