SCHEMBL378846

SCHEMBL378846

N#Cc1cc(F)ccc1O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA3 P07451 1/20 0.44
CA6 P23280 1/20 0.44
CA5A P35218 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
CA5B Q9Y2D0 1/20 0.44
XDH P47989 1/20 0.41
ESR1 P03372 8/20 0.40
ESR2 Q92731 8/20 0.40
SNCA P37840 1/20 0.39
HSD17B1 P14061 1/20 0.38
HSD17B2 P37059 1/20 0.38
TRPV4 Q9HBA0 1/20 0.38
MEN1 O00255 1/20 0.37
GAA P10253 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
P4HB P07237 1/20 0.37
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30945187 1.00 CA3 (0.44) CA3CA6CA5ACA9CA14
SCHEMBL2525720 0.82 CA3 (0.50) CA3CA6CA5ACA9CA14
SCHEMBL28161686 0.79 ESR1 (0.43) CA3CA6CA5ACA9CA14
SCHEMBL573864 0.78 MAOB (0.53) TRPV4MAOAMAOB
SCHEMBL28406222 0.77 CA3 (0.44) CA3CA6CA5ACA9CA14
SCHEMBL74807 0.76 TRPV4 (0.46) CA3CA6CA5ACA9CA14
SCHEMBL21116203 0.76 USP8 (0.42) TRPV4MAOAMAOB
SCHEMBL1267040 0.76 ESR2 (0.44) CA3CA6CA9CA14XDH
SCHEMBL28843641 0.75 AR (0.41) CA9ESR2MEN1KMT2A
Bromide SCHEMBL28616522 0.74 ESR2 (0.43) CA3CA6CA9CA14XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 208 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115557929-A Somatostatin modulators and uses thereof 克林提克斯医药股份有限公司 2023-01-03 CN claimed
EP-3484865-B1 SOMATOSTATIN MODULATORS AND USES THEREOF CRINETICS PHARMACEUTICALS INC (US) 2022-09-14 EP claimed
US-11414397-B2 Somatostatin modulators and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2022-08-16 US claimed
EP-0103918-A2 Pesticidal benzoylurea compounds SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1984-03-28 EP claimed
JP-59161349-A None JP disclosed
JP-59134767-A None JP disclosed
US-20260028352-A1 MACROCYCLIC IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF SUZHOU LANGRUI BIOPHARMACEUTICAL CO LTD (CN) 2026-01-29 US disclosed
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2026-01-22 US disclosed
US-12459929-B2 GPCR receptor agonists, pharmaceutical compositions comprising the same, and methods for their use CARMOT THERAPEUTICS INC. (US) 2025-11-04 US disclosed
EP-4585598-A1 MACROCYCLIC IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF Suzhou Langrui Biopharmaceutical Co., Ltd. (CN) 2025-07-16 EP disclosed
US-20250197388-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE EMPRESS THERAPEUTICS, INC. 2025-06-19 US disclosed
EP-4563199-A2 GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE Carmot Therapeutics, Inc. (US) 2025-06-04 EP disclosed
EP-0152014-B1 2-CYANO-4-HALOGENOPHENYL SUBSTITUTED-BENZOATES AND LIQUID CRYSTAL COMPOSITIONS CONTAINING THEM Chisso Corporation (JP) 1988-04-20 EP disclosed
US-4659501-A LIQUID CRYSTALS CHISSO CORPORATION (JP) 1987-04-21 US disclosed
US-4603018-A NEGATIVE DIELECTRIC ANISOTROPIC LIQUID CRYSTALS CHISSO CORPORATION (JP) 1986-07-29 US disclosed
EP-0106588-B1 2-CYANO-4-HALOGENOPHENYL ESTERS Chisso Corporation (JP) 1986-04-30 EP disclosed
EP-0152014-A2 2-Cyano-4-halogenophenyl substituted-benzoates and liquid crystal compositions containing them Chisso Corporation (JP) 1985-08-21 EP disclosed
JP-S59161349-A LIQUID CRYSTAL COMPOUND WITH NEGATIVE DIELECTRIC ANISOTROPY CHISSO CORP 1984-09-12 JP disclosed
JP-S59134767-A ESTER COMPOUND HAVING NEGATIVE DIELECTRIC ANISOTROPY CHISSO CORP 1984-08-02 JP disclosed
EP-0106588-A1 2-Cyano-4-halogenophenyl esters Chisso Corporation (JP) 1984-04-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11414397-B2 Somatostatin modulators and uses thereof SSTR5, SSTR2, SSTR4 CA3 2191/4885CA6 1209/4885CA5A 800/4885
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LIPA, LPL CA3 1760/4885CA6 591/4885CA5A 2182/4885
US-12459929-B2 GPCR receptor agonists, pharmaceutical compositions comprising the same, and methods for their use GLP1R, GCGR, GIPR CA3 4766/4885CA6 4244/4885CA5A 2980/4885
US-20250197388-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE SI, VIP, APC CA3 4131/4885CA6 576/4885CA5A 3216/4885
US-20260028352-A1 MACROCYCLIC IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF WEE2, WEE1, ROR1 CA3 3990/4885CA6 3629/4885CA5A 3508/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.