SCHEMBL2525720

SCHEMBL2525720

N#Cc1ccc(F)cc1O

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA3 P07451 1/20 0.50
CA6 P23280 1/20 0.50
CA5A P35218 1/20 0.50
CA9 Q16790 1/20 0.50
CA14 Q9ULX7 1/20 0.50
CA5B Q9Y2D0 1/20 0.50
TRPV4 Q9HBA0 1/20 0.42
P4HB P07237 2/20 0.41
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
CYP11B1 P15538 2/20 0.40
CYP11B2 P19099 2/20 0.40
AR P10275 5/20 0.39
FFAR1 O14842 1/20 0.38
FFAR4 Q5NUL3 1/20 0.38
PGR P06401 1/20 0.38
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30945187 0.82 CA3 (0.44) CA3CA6CA5ACA9CA14
SCHEMBL378846 0.82 CA3 (0.44) CA3CA6CA5ACA9CA14
SCHEMBL573864 0.78 MAOB (0.53) TRPV4MAOAMAOBCYP11B1CYP11B2
SCHEMBL30919072 0.76 TRPV4 (0.61) TRPV4MAOAMAOBCYP11B1CYP11B2
SCHEMBL57346 0.76 TRPV4 (0.61) TRPV4MAOAMAOBCYP11B1CYP11B2
SCHEMBL1267080 0.76 ESR2 (0.44) CA3CA6CA9CA14AR
SCHEMBL21131569 0.76 TRPV4 (0.45) TRPV4MAOAMAOBCYP11B1CYP11B2
SCHEMBL28843641 0.75 AR (0.41) CA9ARPGRESR2
SCHEMBL28161686 0.75 ESR1 (0.43) CA3CA6CA5ACA9CA14
SCHEMBL3027689 0.74 CA12 (0.48) CA3CA6CA9CA14AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-9143139-A None JP disclosed
CN-122080069-A Phospholipid compounds and uses thereof 2026-05-26 CN disclosed
US-20260021192-A1 PROTEINS HAVING A COVALENT WARHEAD TOPAZ THERAPEUTICS INC (US) 2026-01-22 US disclosed
US-12473314-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES, INC. (US) 2025-11-18 US disclosed
US-12466803-B2 BCKDK inhibitors and/or degraders PFIZER INC. (US) 2025-11-11 US disclosed
EP-4615578-A1 CYCLIC PYRIDINE DERIVATIVES AS CGAS INHIBITORS Boehringer Ingelheim International GmbH (DE) 2025-09-17 EP disclosed
US-20250257076-A1 SUBSTITUTED PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS cGAS INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2025-08-14 US disclosed
US-20250197388-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE EMPRESS THERAPEUTICS, INC. 2025-06-19 US disclosed
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-05-13 US disclosed
EP-4537828-A2 PHOSPHOLIPID COMPOUNDS AND USES THEREOF Gilead Sciences, Inc. (US) 2025-04-16 EP disclosed
US-7157447-B2 Bicyclic heterocycles as HIV integrase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2007-01-02 US disclosed
US-20060276466-A1 Bicyclic heterocycles as HIV integrase inhibitors NAIDU B N 2006-12-07 US disclosed
EP-1710233-A1 NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE Kissei Pharmaceutical Co., Ltd. (JP) 2006-10-11 EP disclosed
US-20060199956-A1 Bicyclic heterocycles as HIV integrase inhibitors BRISTOL-MYERS SQUIBB COMPANY 2006-09-07 US disclosed
WO-2005118593-A1 BICYCLIC HETEROCYCLES AS HIV INTEGRASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2005-12-15 WO disclosed
US-20050267105-A1 Bicyclic heterocycles as HIV integrase inhibitors BRISTOL-MYERS SQUIBB COMPANY 2005-12-01 US disclosed
JP-H09143139-A PRODUCTION OF CYANOFLUOROPHENOL TOHKEM PROD:KK 1997-06-03 JP disclosed
US-5264538-A Cyclic poly(aryl ether) oligomers THE DOW CHEMICAL COMPANY (US) 1993-11-23 US disclosed
US-5264520-A Polymerization of cyclic poly(aryl ether) oligomers THE DOW CHEMICAL COMPANY (US) 1993-11-23 US disclosed
EP-0413257-A2 Cyclic poly(aryl ether) oligomers, a process for preparation thereof, and polymerization of cyclic poly (aryl ether) oligomers THE DOW CHEMICAL COMPANY (US) 1991-02-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12466803-B2 BCKDK inhibitors and/or degraders BCKDK, KHK, PDK4 CA3 3550/4885CA6 2288/4885CA5A 1121/4885
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 CA3 1575/4885CA6 2043/4885CA5A 897/4885
US-20250197388-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE SI, VIP, APC CA3 4131/4885CA6 576/4885CA5A 3216/4885
US-20060199956-A1 Bicyclic heterocycles as HIV integrase inhibitors CCNI, TYMP, IMPDH1 CA3 4689/4885CA6 4668/4885CA5A 3101/4885
US-20250257076-A1 SUBSTITUTED PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS cGAS INHIBITORS CGAS, SSB, FPGS CA3 2797/4885CA6 3228/4885CA5A 368/4885
US-20060276466-A1 Bicyclic heterocycles as HIV integrase inhibitors CCNI, TYMP, IMPDH1 CA3 4689/4885CA6 4668/4885CA5A 3101/4885
US-20050267105-A1 Bicyclic heterocycles as HIV integrase inhibitors CCNI, TYMP, IMPDH1 CA3 4689/4885CA6 4668/4885CA5A 3101/4885
US-20260021192-A1 PROTEINS HAVING A COVALENT WARHEAD RIOX2, ORC3, DCLRE1A CA3 3652/4885CA6 3719/4885CA5A 1774/4885
US-12473314-B2 Phospholipid compounds and uses thereof PHOSPHO1, SGMS2, SGMS1 CA3 4182/4885CA6 2987/4885CA5A 1864/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.