SCHEMBL3789673

SCHEMBL3789673

CCc1cccc(N)c1Cl

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 4/20 0.44
GABRB2 P47870 4/20 0.44
HTR1A P08908 3/20 0.44
DRD2 P14416 3/20 0.44
DRD4 P21917 3/20 0.44
HTR2A P28223 3/20 0.44
HTR2C P28335 3/20 0.44
DRD3 P35462 3/20 0.44
PNMT P11086 1/20 0.41
ALDH1A1 P00352 1/20 0.41
TSHR P16473 2/20 0.39
CYP3A4 P08684 1/20 0.39
PIK3CA P42336 1/20 0.39
TAAR1 Q96RJ0 1/20 0.38
PARP1 P09874 1/20 0.37
NR4A2 P43354 1/20 0.37
IDO1 P14902 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2200675 0.83 GABRA1 (0.55) GABRA1GABRB2HTR1ADRD2DRD4
SCHEMBL3786513 0.83 TAAR1 (0.44) PNMTALDH1A1TSHRCYP3A4PIK3CA
SCHEMBL5591177 0.81 PNMT (0.62) PNMTALDH1A1TSHRCYP3A4TAAR1
SCHEMBL699759 0.81 PNMT (0.44) PNMTALDH1A1TSHRCYP3A4PIK3CA
SCHEMBL3783958 0.79 TAAR1 (0.41) PNMTALDH1A1TAAR1
SCHEMBL21852155 0.79 POLB (0.40) GABRA1GABRB2HTR1ADRD2DRD4
Nitrogen SCHEMBL10979594 0.78 GABRA1 (0.50) GABRA1GABRB2HTR1ADRD2DRD4
SCHEMBL29565534 0.78
SCHEMBL39547 0.78
Ethylene SCHEMBL1818621 0.77 PNMT (0.41) PNMTALDH1A1TSHRCYP3A4PIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3848351-B1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF US HEALTH (US) 2025-01-15 EP disclosed
US-20240408084-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-12-12 US disclosed
US-12162861-B2 Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-12-10 US disclosed
US-12097196-B2 Dopamine D3 receptor selective antagonists/partial agonists and uses thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-09-24 US disclosed
US-20230010886-A1 SHP2 INHIBITORS AND USES THEREOF Suzhou Puhe BioPharma Co., Ltd. (CN) 2023-01-12 US disclosed
US-20220265643-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2022-08-25 US disclosed
US-20220185798-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2022-06-16 US disclosed
US-20220185798-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2022-06-16 US disclosed
US-11337971-B2 Dopamine D3 receptor selective antagonists/partial agonists and uses thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-05-24 US disclosed
US-11337971-B2 Dopamine D3 receptor selective antagonists/partial agonists and uses thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-05-24 US disclosed
US-20200291000-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2020-09-17 US disclosed
US-20200291000-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2020-09-17 US disclosed
WO-2020055725-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2020-03-19 WO disclosed
US-10561655-B2 SHP2 inhibitors and uses thereof SYNBLIA THERAPEUTICS, INC. (US) 2020-02-18 US disclosed
US-20190290649-A1 SHP2 INHIBITORS AND USES THEREOF Suzhou Puhe BioPharma Co., Ltd. (CN) 2019-09-26 US disclosed
EP-3429993-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) 2019-01-23 EP disclosed
WO-2017160552-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2017-09-21 WO disclosed
WO-2017160552-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2017-09-21 WO disclosed
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2010-04-08 US disclosed
EP-1914221-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-04-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230010886-A1 SHP2 INHIBITORS AND USES THEREOF PTPN1, PTPN7, PTPN18 GABRA1 3604/4885GABRB2 3264/4885HTR1A 4727/4885
US-20220185798-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF DRD3, DRD2, SLC6A3 GABRA1 229/4885GABRB2 331/4885HTR1A 45/4885
US-12162861-B2 Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof DRD3, DRD2, SLC6A3 GABRA1 229/4885GABRB2 331/4885HTR1A 45/4885
US-20200291000-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF DRD3, DRD2, SLC6A3 GABRA1 229/4885GABRB2 331/4885HTR1A 45/4885
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND NISCH, BLVRB, BBOX1 GABRA1 991/4885GABRB2 561/4885HTR1A 3657/4885
US-12097196-B2 Dopamine D3 receptor selective antagonists/partial agonists and uses thereof OPRD1, OPRK1, DRD3 GABRA1 221/4885GABRB2 295/4885HTR1A 54/4885
US-20240408084-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF DRD3, OPRD1, DRD2 GABRA1 168/4885GABRB2 208/4885HTR1A 65/4885
US-20220265643-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF OPRD1, OPRK1, DRD3 GABRA1 221/4885GABRB2 295/4885HTR1A 54/4885
US-20190290649-A1 SHP2 INHIBITORS AND USES THEREOF PTPN1, PTPN7, PTPN18 GABRA1 3604/4885GABRB2 3264/4885HTR1A 4727/4885
US-11337971-B2 Dopamine D3 receptor selective antagonists/partial agonists and uses thereof OPRD1, OPRK1, DRD3 GABRA1 221/4885GABRB2 295/4885HTR1A 54/4885
US-10561655-B2 SHP2 inhibitors and uses thereof PTPN1, PTPN7, PTPN18 GABRA1 3604/4885GABRB2 3264/4885HTR1A 4727/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.