Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10725489 | 0.79 | NQO1 (0.32) | NQO1 | |
| SCHEMBL11256631 | 0.79 | — | — | |
| SCHEMBL11269884 | 0.79 | — | — | |
| SCHEMBL11352281 | 0.72 | — | — | |
| SCHEMBL10751581 | 0.72 | — | — | |
| SCHEMBL10730755 | 0.71 | — | — | |
| SCHEMBL9411519 | 0.71 | — | — | |
| SCHEMBL9411475 | 0.71 | — | — | |
| SCHEMBL9411419 | 0.71 | — | — | |
| SCHEMBL11497032 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210363164-A1 | Hydroxide-Catalyzed Formation Of Silicon-Oxygen Bonds By Dehydrogenative Coupling Of Hydrosilanes And Alcohols | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2021-11-25 | — | — | US | claimed |
| EP-3865491-A1 | SILYL ETHERS AS PRODUCTS OF THE HYDROXIDE-CATALYZED FORMATION OF SILICON-OXYGEN BONDS BY DEHYDROGENATIVE COUPLING OF HYDROSILANES AND ALCOHOLS | California Institute of Technology (US) | 2021-08-18 | — | — | EP | claimed |
| US-10927065-B2 | Silylations of aromatic substrates with base-activated organosilanes | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-02-23 | — | — | US | claimed |
| US-10781221-B2 | Preparation of aromatic-substituted silylamines by the dehydrogenative coupling of aromatic-substituted amine N—H and Si—H bonds | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2020-09-22 | — | — | US | claimed |
| EP-3177630-B1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INST OF TECHN (US) | 2019-10-23 | — | — | EP | claimed |
| US-20190218232-A1 | Preparation Of Aromatic-Substituted Silylamines By The Dehydrogenative Coupling Of Aromatic-Substituted Amine N-H And Si-H Bonds | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-07-18 | — | — | US | claimed |
| US-20180155271-A1 | SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2018-06-07 | — | — | US | claimed |
| US-9908840-B2 | Reactions of aromatic substrates with base-activated hydrosilanes-silylations and reductive cleavage | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-03-06 | — | — | US | claimed |
| US-9809607-B2 | Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-11-07 | — | — | US | claimed |
| US-9764995-B2 | Silylation of aromatic heterocycles by disilanes using potassium alkoxide catalysts | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-09-19 | — | — | US | claimed |
| US-20170088562-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY DISILANES USING POTASSIUM ALKOXIDE CATALYSTS | NATIONAL SCIENCE FOUNDATION | 2017-03-30 | — | — | US | claimed |
| WO-2014055586-A1 | TRANSITION-METAL FREE REDUCTIVE CLEAVAGE OF AROMATIC C-O, C-N, AND C-S BONDS BY ACTIVATED SILANES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-04-10 | — | — | WO | claimed |
| EP-3303350-B1 | BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS | CALIFORNIA INST OF TECHN (US) | 2023-11-22 | — | — | EP | disclosed |
| EP-3419982-B1 | NEW STABLE SILYLATING REAGENTS | CALIFORNIA INST OF TECHN (US) | 2023-11-15 | — | — | EP | disclosed |
| US-11773116-B2 | Hydrosilylamines and fluorosilylamines and methods of making the same | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2023-10-03 | — | — | US | disclosed |
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2023-09-12 | — | — | US | disclosed |
| WO-2007130306-A2 | ORTHO-METALLATED HAFNIUM COMPLEXES OF IMIDAZOLE LIGANDS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2007-11-15 | — | — | WO | disclosed |
| US-5498419-A | SIDE EFFECT REDUCTION | PARS HARRY G (US) | 1996-03-12 | — | — | US | disclosed |
| WO-1995033429-A1 | FUMARATE SALT OF 4-(DIETHYL-3-(1-METHYLOCTYL)- 7, 8, 9, 10-TETRAHYDRO-6, 6, 9-TRIMETHYL-6H-DIBENZO[B, D]PYRAN-1-OL, 4-(DIETHYL-AMINO)BUTYRIC ACID ESTER | PARS HARRY G (US) | 1995-12-14 | — | — | WO | disclosed |
| EP-0221293-B1 | 7,8,9,10-Tetrahydro-6-oxo-6H-dibenzo[b,d]pyranyloxy-propanes | PENNWALT CORPORATION (US) | 1989-03-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927065-B2 | Silylations of aromatic substrates with base-activated organosilanes | TYR, DDC, TPST2 | NQO1 456/4885 |
| US-20180155271-A1 | SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES | TYR, DDC, TPST2 | NQO1 456/4885 |
| US-10781221-B2 | Preparation of aromatic-substituted silylamines by the dehydrogenative coupling of aromatic-substituted amine N—H and Si—H bonds | HNMT, HRH3, ALKBH3 | NQO1 489/4885 |
| US-20190218232-A1 | Preparation Of Aromatic-Substituted Silylamines By The Dehydrogenative Coupling Of Aromatic-Substituted Amine N-H And Si-H Bonds | HRH3, HNMT, HNRNPH3 | NQO1 559/4885 |
| US-20210363164-A1 | Hydroxide-Catalyzed Formation Of Silicon-Oxygen Bonds By Dehydrogenative Coupling Of Hydrosilanes And Alcohols | SORD, ADH1A, ADH1C | NQO1 495/4885 |
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | NQO1 297/4885 |
| US-20170088562-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY DISILANES USING POTASSIUM ALKOXIDE CATALYSTS | KCNH3, KCNH2, KCNH1 | NQO1 970/4885 |
| US-11773116-B2 | Hydrosilylamines and fluorosilylamines and methods of making the same | HNMT, PNMT, BHMT2 | NQO1 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.