Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | FAAH | O00519 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | AANAT | Q16613 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431608 | 0.91 | MAPT (0.84) | MAPTALDH1A1GAAHPGDRECQL | |
| SCHEMBL12371556 | 0.88 | MAPT (0.78) | MAPTALDH1A1GAAHPGDHTT | |
| SCHEMBL1520411 | 0.86 | MAPT (0.76) | MAPTALDH1A1GAAHPGDHTT | |
| SCHEMBL6275395 | 0.85 | ALDH1A1 (0.74) | MAPTALDH1A1GAAHPGDHTT | |
| SCHEMBL947150 | 0.84 | MAPT (0.73) | MAPTALDH1A1GAAHPGDKMT2A | |
| SCHEMBL29634969 | 0.84 | MAPT (0.72) | MAPTALDH1A1GAAHPGDHTT | |
| SCHEMBL8998855 | 0.84 | MAPT (0.72) | MAPTALDH1A1GAAHPGDHTT | |
| SCHEMBL7677886 | 0.84 | MEN1 (0.84) | MAPTALDH1A1GAAGFERKMT2A | |
| SCHEMBL27099044 | 0.83 | MTNR1A (0.77) | MAPTALDH1A1GAAHPGDHTT | |
| SCHEMBL664283 | 0.83 | MAPT (0.70) | MAPTALDH1A1GAAHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740208-B1 | COMPOUNDS FOR TREATING RAC-GTPASE MEDIATED DISORDER | CHILDRENS MEDICAL CENTER (US) | 2023-10-25 | — | — | EP | disclosed |
| US-11685733-B2 | Compounds for treating Rac-GTPase mediated disorder | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2023-06-27 | — | — | US | disclosed |
| US-11685733-B2 | Compounds for treating Rac-GTPase mediated disorder | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2023-06-27 | — | — | US | disclosed |
| US-11685733-B2 | Compounds for treating Rac-GTPase mediated disorder | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2023-06-27 | — | — | US | disclosed |
| EP-3740208-A1 | COMPOUNDS FOR TREATING RAC-GTPASE MEDIATED DISORDER | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2020-11-25 | — | — | EP | disclosed |
| US-20200347044-A1 | Compounds for Treating Rac-GTPase Mediated Disorder | CHILDREN'S MEDICAL CENTER CORPORATION | 2020-11-05 | — | — | US | disclosed |
| US-20200347044-A1 | Compounds for Treating Rac-GTPase Mediated Disorder | CHILDREN'S MEDICAL CENTER CORPORATION | 2020-11-05 | — | — | US | disclosed |
| WO-2019143833-A1 | COMPOUNDS FOR TREATING RAC-GTPASE MEDIATED DISORDER | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2019-07-25 | — | — | WO | disclosed |
| WO-2019143833-A1 | COMPOUNDS FOR TREATING RAC-GTPASE MEDIATED DISORDER | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2019-07-25 | — | — | WO | disclosed |
| EP-1915149-B1 | NOVEL TRIAZOLE DERIVATIVES AS GHRELIN ANALOGUE LIGANDS OF GROWTH HORMONE SECRETAGOGUE RECEPTORS | AETERNA ZENTARIS GMBH (DE) | 2018-10-10 | — | — | EP | disclosed |
| EP-2103602-A1 | Novel 1,2,4-triazole derivatives and process of manufacturing thereof | AEterna Zentaris GmbH (DE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2009065854-A1 | N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2009-05-28 | — | — | WO | disclosed |
| US-20090042905-A1 | TRIAZOLE DERIVATIVES AS LIGANDS OF G-PROTEIN COUPLED RECEPTORS | AETERNA ZENTARIS GMBH (DE) | 2009-02-12 | — | — | US | disclosed |
| WO-2008098977-A1 | NOVEL TRIAZOLE DERIVATIVES AS LIGANDS OF G-PROTEIN COUPLED RECEPTORS | ÆTERNA ZENTARIS GMBH (DE) | 2008-08-21 | — | — | WO | disclosed |
| EP-1958631-A1 | Novel triazole derivatives as ligands of G-protein coupled receptors | AEterna Zentaris GmbH (DE) | 2008-08-20 | — | — | EP | disclosed |
| EP-1915149-A2 | NOVEL TRIAZOLE DERIVATIVES AS GHRELIN ANALOGUE LIGANDS OF GROWTH HORMONE SECRETAGOGUE RECEPTORS | AEterna Zentaris GmbH (DE) | 2008-04-30 | — | — | EP | disclosed |
| US-20070208061-A2 | NOVEL TRIAZOLE DERIVATIVES AS GHRELIN ANALOGUE LIGANDS OF GROWTH HORMONE SECRETAGOGUE RECEPTORS | ZENTARIS GMBH (DE) | 2007-09-06 | — | — | US | disclosed |
| EP-1757290-A1 | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors | Zentaris GmbH (DE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2007020013-A2 | NOVEL TRIAZOLE DERIVATIVES AS GHRELIN ANALOGUE LIGANDS OF GROWTH HORMONE SECRETAGOGUE RECEPTORS | ÆTERNA ZENTARIS GMBH (DE) | 2007-02-22 | — | — | WO | disclosed |
| US-20070037857-A1 | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors | ZENTARIS GMBH (DE) | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685733-B2 | Compounds for treating Rac-GTPase mediated disorder | ARHGDIB, ARHGEF2, ARHGDIA | MAPT 3225/4885ALDH1A1 3084/4885GAA 911/4885 |
| US-20070208061-A2 | NOVEL TRIAZOLE DERIVATIVES AS GHRELIN ANALOGUE LIGANDS OF GROWTH HORMONE SECRETAGOGUE RECEPTORS | GIPR, GHSR, GPR119 | MAPT 4829/4885ALDH1A1 3459/4885GAA 1604/4885 |
| US-20200347044-A1 | Compounds for Treating Rac-GTPase Mediated Disorder | ARHGDIB, ARHGEF2, ARHGDIA | MAPT 3225/4885ALDH1A1 3084/4885GAA 911/4885 |
| US-20070037857-A1 | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors | GIPR, GHSR, GPR119 | MAPT 4829/4885ALDH1A1 3459/4885GAA 1604/4885 |
| US-20090042905-A1 | TRIAZOLE DERIVATIVES AS LIGANDS OF G-PROTEIN COUPLED RECEPTORS | GPR3, GRK3, GPR88 | MAPT 4470/4885ALDH1A1 2149/4885GAA 3696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.