Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 12/20 | 0.58 |
| ▸ | BCHE | P06276 | 6/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.58 |
| ▸ | ACHE | P22303 | 4/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3962959 | 0.94 | CHRM2 (0.63) | ALDH1A1CHRM2BCHEGRIN1GRIN2A | |
| SCHEMBL13330463 | 0.90 | ALDH1A1 (0.63) | ALDH1A1CHRM2BCHEGRIN1GRIN2A | |
| SCHEMBL3268488 | 0.85 | CHRM2 (0.78) | CHRM2BCHEGRIN1GRIN2AACHE | |
| SCHEMBL7000552 | 0.85 | KDM4E (0.69) | ALDH1A1BCHECYP3A4CYP2D6TSHR | |
| SCHEMBL31711441 | 0.83 | KDM4E (0.60) | ALDH1A1BCHECYP3A4CYP2D6TSHR | |
| SCHEMBL917350 | 0.80 | ALDH1A1 (0.56) | ALDH1A1CHRM2BCHEGRIN1GRIN2A | |
| SCHEMBL28058011 | 0.80 | ALDH1A1 (0.56) | ALDH1A1CHRM2BCHEGRIN1GRIN2A | |
| SCHEMBL8655974 | 0.79 | BCHE (0.82) | CHRM2BCHEGRIN1GRIN2A | |
| SCHEMBL27142965 | 0.79 | SMPD1 (0.56) | ALDH1A1BCHEHTR2AHTR2C | |
| SCHEMBL13570066 | 0.78 | ALOX5 (0.60) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488844-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2009-02-10 | — | — | US | disclosed |
| US-7355069-B2 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance | ASTRAZENECA AB (SE) | 2008-04-08 | — | — | US | disclosed |
| EP-1517883-B1 | ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF INSULIN RESISTANCE | ASTRAZENECA AB (SE) | 2008-02-13 | — | — | EP | disclosed |
| US-20070244198-A1 | Carboxylic Derivatives | LI LANNA | 2007-10-18 | — | — | US | disclosed |
| US-20060258866-A1 | Carboxylic derivates | ASTRAZENECA AB, A SWEDEN CORPORATION | 2006-11-16 | — | — | US | disclosed |
| EP-1675820-A2 | PROPIONIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF LIPID DISORDERS | AstraZeneca AB (SE) | 2006-07-05 | — | — | EP | disclosed |
| EP-1676833-A1 | Propionic acid derivatives useful in the treatment of lipid disorders | AstraZeneca AB (SE) | 2006-07-05 | — | — | EP | disclosed |
| US-20050282822-A1 | Therapeutic agents | ASTRAZENECA AB (SE) | 2005-12-22 | — | — | US | disclosed |
| US-20050256198-A1 | Ortho-substituted benzoic acid derivatives for the treatmetn of insulin resistance | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
| US-20050148656-A1 | 3-(amino-oxo(alkyl, alkyloxy and alkylthio)phenyl) propanoic and propenoic acid derivatives; peroxisome proliferator-activated receptors agonists; dyslipidemias with or without insulin resisitance and associated metabolic disorders (metabolic syndrome) including obesity, hypertension, type 2 diabetes | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | US | disclosed |
| WO-2004113270-A2 | PROPIONIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF LIPID DISORDERS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244198-A1 | Carboxylic Derivatives | GPR119, CPT1A, PC | ALDH1A1 323/4885CHRM2 2845/4885BCHE 1133/4885 |
| US-20050148656-A1 | 3-(amino-oxo(alkyl, alkyloxy and alkylthio)phenyl) propanoic and propenoic acid derivatives; peroxisome proliferator-activated receptors agonists; dyslipidemias with or without insulin resisitance and associated metabolic disorders (metabolic syndrome) including obesity, hypertension, type 2 diabetes | GPR119, PPARA, PPARG | ALDH1A1 1343/4885CHRM2 2177/4885BCHE 4358/4885 |
| US-20060258866-A1 | Carboxylic derivates | GPR119, PC, CPT1A | ALDH1A1 230/4885CHRM2 2535/4885BCHE 911/4885 |
| US-20050282822-A1 | Therapeutic agents | GPR119, LIPC, PNLIP | ALDH1A1 1921/4885CHRM2 4274/4885BCHE 2688/4885 |
| US-20050256198-A1 | Ortho-substituted benzoic acid derivatives for the treatmetn of insulin resistance | GPR119, INSR, IRS1 | ALDH1A1 1160/4885CHRM2 1268/4885BCHE 2365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.