Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973213 | 0.99 | HTR2A (0.42) | HTR2APOLBSMN1; SMN2HTR4KDR | |
| SCHEMBL4084541 | 0.89 | SYK (0.45) | SMN1; SMN2KDRLMNACYP2D6TSHR | |
| SCHEMBL4081651 | 0.84 | LMNA (0.46) | DRD2DRD3LMNACYP2D6CYP2C9 | |
| SCHEMBL3973494 | 0.83 | IDH1 (0.39) | POLBSMN1; SMN2MEN1CYP3A4TSHR | |
| SCHEMBL3972272 | 0.81 | CA1 (0.38) | ACHE | |
| SCHEMBL3973824 | 0.81 | HTR2A (0.36) | HTR2ASMN1; SMN2KDRDRD2 | |
| SCHEMBL3979633 | 0.81 | POLB (0.43) | POLBSMN1; SMN2DRD2DRD3MEN1 | |
| SCHEMBL3971360 | 0.79 | ALDH1A1 (0.43) | KDRMEN1CYP3A4CYP2D6THPO | |
| SCHEMBL3973796 | 0.79 | HSD17B10 (0.46) | SMN1; SMN2HTR2CCYP2D6CYP2C9TSHR | |
| SCHEMBL3973411 | 0.78 | CNR2 (0.45) | KCNH2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009051417-A2 | PHENANTHRENE LACTAM DERIVATIVES HAVING ANTICANCER ACTIVITY AND METHOD FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2009-04-23 | — | — | WO | disclosed |