Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 3/20 | 0.72 |
| ▸ | CTRC | Q99895 | 3/20 | 0.55 |
| ▸ | MPL | P40238 | 3/20 | 0.55 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | GLB1 | P16278 | 1/20 | 0.48 |
| ▸ | CHAT | P28329 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | SLC7A11 | Q9UPY5 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3771521 | 0.85 | MPL (0.71) | THRBCTRCMPLCTRB1PHLPP2 | |
| SCHEMBL3771513 | 0.85 | MPL (0.71) | THRBCTRCMPLCTRB1PHLPP2 | |
| E122 SCHEMBL2833594 | 0.84 | THRB (1.00) | THRBCTRCMPLCTRB1APP | |
| E122 SCHEMBL29360316 | 0.84 | THRB (1.00) | THRBCTRCMPLCTRB1APP | |
| E122 SCHEMBL42707 | 0.84 | THRB (1.00) | THRBCTRCMPLCTRB1APP | |
| E122 SCHEMBL29360683 | 0.84 | THRB (1.00) | THRBCTRCMPLCTRB1APP | |
| Eriochrome Blue Black B SCHEMBL18281602 | 0.84 | MPL (0.78) | THRBCTRCMPLCTRB1CYP1A2 | |
| Eriochrome Blue Black B SCHEMBL591901 | 0.84 | MPL (0.78) | THRBCTRCMPLCTRB1CYP1A2 | |
| Eriochrome Blue Black B SCHEMBL29923948 | 0.84 | MPL (0.78) | THRBCTRCMPLCTRB1CYP1A2 | |
| SCHEMBL28997504 | 0.84 | THRB (0.57) | THRBCTRCMPLCTRB1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7537620-B2 | Agent for coloring keratin fibers | WELLA AG (DE) | 2009-05-26 | — | — | US | disclosed |
| US-20080229520-A1 | Hair Colorants with Indigoid Vat Dyes | WELLA AG (DE) | 2008-09-25 | — | — | US | disclosed |
| US-20070258928-A1 | Agent for Coloring Keratin Fibers | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2007-11-08 | — | — | US | disclosed |
| US-20070180630-A1 | Hair colorants with vat dyes | WELLA AG (DE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070258928-A1 | Agent for Coloring Keratin Fibers | KRT18, TUBB1, TUBA4A | THRB 3194/4885CTRC 2082/4885MPL 4846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.