Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of E122. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.55 |
| ▸ | CTRC | Q99895 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | GLB1 | P16278 | 1/20 | 0.54 |
| ▸ | CHAT | P28329 | 1/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.54 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.54 |
| ▸ | SLC7A11 | Q9UPY5 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| E122 SCHEMBL29360683 | 1.00 | THRB (1.00) | THRBCYP1A2CTRB1CTRCAPP | |
| E122 SCHEMBL29360316 | 1.00 | THRB (1.00) | THRBCYP1A2CTRB1CTRCAPP | |
| E122 SCHEMBL2833594 | 1.00 | THRB (1.00) | THRBCYP1A2CTRB1CTRCAPP | |
| E122 SCHEMBL3208444 | 0.95 | THRB (0.90) | THRBCYP1A2CTRB1CTRCAPP | |
| E122 SCHEMBL4806638 | 0.95 | THRB (0.90) | THRBCYP1A2CTRB1CTRCAPP | |
| SCHEMBL9017566 | 0.85 | THRB (0.73) | THRBCYP1A2CTRB1CTRCAPP | |
| SCHEMBL29382082 | 0.84 | THRB (0.74) | THRBCYP1A2CTRCAPPGLB1 | |
| SCHEMBL4020467 | 0.84 | THRB (0.72) | THRBCYP1A2CTRB1CTRCAPP | |
| E122 SCHEMBL345295 | 0.84 | CYP1A2 (0.78) | THRBCYP1A2CTRB1CTRCAPP | |
| E122 SCHEMBL110093 | 0.84 | CYP1A2 (0.78) | THRBCYP1A2CTRB1CTRCAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2564 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4716527-A1 | A MULTIPLE UNIT ORAL DOSAGE FORM OF DOXYLAMINE SUCCINATE AND PYRIDOXINE HYDROCHLORIDE FREE OF TITANIUM DIOXIDE | Italfarmaco SpA (IT) | 2026-04-01 | — | — | EP | claimed |
| EP-4378311-B1 | METHOD TO PREPARE COLOURED CHLORHEXIDINE COMPOSITIONS | BARNA IMP MEDICA S A (ES) | 2026-04-01 | — | — | EP | claimed |
| EP-3958926-B1 | MULTIVASCULAR NETWORKS AND FUNCTIONAL INTRAVASCULAR TOPOLOGIES WITHIN BIOCOMPATIBLE HYDROGELS | UNIV RICE WILLIAM M (US) | 2025-08-20 | — | — | EP | claimed |
| US-20250243348-A1 | Food Grade Starch Based Modeling Clay with High Elasticity and High Ductility and Its Preparation Method | JIANGNAN UNIVERSITY (CN) | 2025-07-31 | — | — | US | claimed |
| US-20250186407-A1 | TRANSMUCOSAL THERAPEUTIC SYSTEM CONTAINING A MACROLIDE IMMUNOSUPPRESSANT | NUCLEUS MEDICAL GMBH (DE) | 2025-06-12 | — | — | US | claimed |
| US-12287245-B2 | Time-temperature indicator | E.O.S. S.P.A. (IT) | 2025-04-29 | — | — | US | claimed |
| EP-4489725-A1 | TRANSMUCOSAL THERAPEUTIC SYSTEM CONTAINING A MACROLIDE IMMUNOSUPPRESSANT | LTS Lohmann Therapie-Systeme AG (DE) | 2025-01-15 | — | — | EP | claimed |
| WO-2024240747-A1 | A MULTIPLE UNIT ORAL DOSAGE FORM OF DOXYLAMINE SUCCINATE AND PYRIDOXINE HYDROCHLORIDE FREE OF TITANIUM DIOXIDE | ITALFARMACO S.P.A. (IT) | 2024-11-28 | — | — | WO | claimed |
| EP-4378311-A1 | COLOURED CHLORHEXIDINE COMPOSITIONS | Barna Import Medica, S.A. (ES) | 2024-06-05 | — | — | EP | claimed |
| EP-4058764-B1 | TIME-TEMPERATURE INDICATOR | E O S S P A (IT) | 2023-11-01 | — | — | EP | claimed |
| CN-1240461-A | Polymer film composition for capsules | WARNER LAMBERT CO (US) | 2000-01-05 | — | — | CN | claimed |
| EP-0946637-A1 | POLYMER FILM COMPOSITIONS FOR CAPSULES | WARNER-LAMBERT COMPANY (US) | 1999-10-06 | — | — | EP | claimed |
| WO-1999046329-A1 | POLYVINYL ALCOHOL COMPOSITIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-16 | — | — | WO | claimed |
| WO-1999033924-A1 | GELATINE COMPOSITIONS | WARNER-LAMBERT COMPANY (US) | 1999-07-08 | — | — | WO | claimed |
| US-5866166-A | BLEND OF MICROCRYSTALLINE CELLULOSE AND COMPRESSIBILITY ADJUVANT | EDWARD MENDELL CO., INC. (US) | 1999-02-02 | — | — | US | claimed |
| US-5858412-A | FORMING AQUEOUS SLURRY OF MICROCRYSTALLINE CELLULOSE AND COMPRESSIBILITY AUGMENTING AGENT, DRYING TO FORM AGGLOMERATED PARTICLES, ADDING ACTIVE AGENT, INCORPORATING SUSTAINED-RELEASE CARRIER | EDWARD MENDELL CO., INC. (US) | 1999-01-12 | — | — | US | claimed |
| WO-1998027151-A1 | POLYMER FILM COMPOSITIONS FOR CAPSULES | WARNER-LAMBERT COMPANY (US) | 1998-06-25 | — | — | WO | claimed |
| US-5741524-A | CONTAINING MICROCRYSTALLINE CELLULOSE | EDWARD MENDELL CO., INC. (US) | 1998-04-21 | — | — | US | claimed |
| CN-1080845-A | Color-coded poultry inactivated vaccines | ABIC LTD (IL) | 1994-01-19 | — | — | CN | claimed |
| EP-0565236-A2 | Colour-coded inactivated vaccines for poultry | ABIC LIMITED (IL) | 1993-10-13 | — | — | EP | claimed |