Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | MC1R | Q01726 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 3/20 | 0.36 |
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 4/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040381 | 0.93 | MC4R (0.36) | MC4RMC3RMC1RCTSLCTSS | |
| SCHEMBL4044768 | 0.90 | CTSL (0.44) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4043722 | 0.88 | CTSK (0.40) | MC4RMC3RMC1RCTSLCTSS | |
| SCHEMBL4047478 | 0.88 | MC4R (0.37) | MC4RMC3RMC1RCTSLCTSS | |
| SCHEMBL4045047 | 0.88 | CTSL (0.37) | MC4RMC3RMC1RCTSLCTSS | |
| SCHEMBL4044814 | 0.88 | FNTA (0.35) | MC4RMC3RMC1RGRIA1CTSK | |
| SCHEMBL6210816 | 0.85 | CTSL (0.43) | MC4RMC3RMC1RCTSLCTSS | |
| SCHEMBL4041433 | 0.85 | ALDH1A1 (0.35) | MC4RMC3RMC1RCTSLCTSS | |
| SCHEMBL4042676 | 0.83 | CTSB (0.36) | MC4RMC3RMC1RCTSLCTSS | |
| SCHEMBL4040539 | 0.83 | MC4R (0.41) | MC4RMC3RMC1RCTSKITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |