Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047239 | 0.93 | CTSK (0.34) | CTSKP2RX7OPRM1 | |
| SCHEMBL4043833 | 0.91 | F10 (0.36) | CTSKP2RX7ITGB1ITGA4F10 | |
| SCHEMBL4047305 | 0.89 | P2RX7 (0.37) | CTSKP2RX7ITGB1ITGA4 | |
| SCHEMBL4045552 | 0.89 | ITGB3 (0.37) | CTSKP2RX7ITGB1ITGA4ITGB3 | |
| SCHEMBL4047763 | 0.87 | CTSK (0.44) | CTSK | |
| SCHEMBL4041133 | 0.86 | CTSK (0.36) | CTSKF10F2 | |
| SCHEMBL4051296 | 0.85 | CTSL (0.39) | CTSK | |
| SCHEMBL4047882 | 0.84 | F2 (0.36) | CTSKITGB1F10F2PLG | |
| SCHEMBL4047934 | 0.83 | CTSK (0.51) | CTSKHPGDSF10PLGITGB3 | |
| SCHEMBL4046036 | 0.83 | P2RX7 (0.36) | CTSKP2RX7ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |