Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | PLG | P00747 | 2/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 2/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.34 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046868 | 0.93 | ITGB1 (0.37) | F2KCNQ1ALDH1A1NAMPTCTSB | |
| SCHEMBL4044160 | 0.91 | CTSB (0.37) | NAMPTEPHX1CTSBCTSSCTSK | |
| SCHEMBL4045597 | 0.90 | ACE (0.36) | F2F10PLGST14PLAU | |
| SCHEMBL4043833 | 0.89 | F10 (0.36) | F2F10PLGST14PLAU | |
| SCHEMBL4041436 | 0.89 | ALDH1A1 (0.39) | F2KCNQ1ALDH1A1BCL2GPR132 | |
| SCHEMBL4051296 | 0.88 | CTSL (0.39) | CTSBCTSSCTSK | |
| SCHEMBL4051777 | 0.87 | CTSK (0.44) | KCNQ1ALDH1A1NAMPTCTSBCTSS | |
| SCHEMBL4042165 | 0.86 | EPHX1 (0.37) | EPHX1CTSBCTSSCTSKACE | |
| SCHEMBL4048312 | 0.86 | KCNQ1 (0.40) | KCNQ1ALDH1A1NAMPTCTSKELOVL6 | |
| SCHEMBL4046932 | 0.85 | GPR132 (0.35) | CTSBCTSSCTSKGPR132ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |