Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.36 |
| ▸ | F2 | P00734 | 5/20 | 0.36 |
| ▸ | PLG | P00747 | 5/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 5/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | PLAU | P00749 | 4/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.34 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046036 | 0.92 | P2RX7 (0.36) | CTSKP2RX7ITGB1ITGA4ITGB7 | |
| SCHEMBL4047214 | 0.91 | CTSK (0.33) | F10F2PLGST14CTSK | |
| SCHEMBL4047882 | 0.89 | F2 (0.36) | F10F2PLGST14CTSK | |
| SCHEMBL4041712 | 0.89 | ITGA4 (0.40) | F10F2PLGST14CTSK | |
| SCHEMBL4041901 | 0.89 | P2RX7 (0.39) | CTSKP2RX7ITGB1ITGA4ITGB7 | |
| SCHEMBL4051296 | 0.86 | CTSL (0.39) | CTSK | |
| SCHEMBL4044695 | 0.86 | CTSK (0.36) | CTSKMMP13 | |
| SCHEMBL4046932 | 0.83 | GPR132 (0.35) | CTSKITGA4ITGB7HTRA1 | |
| SCHEMBL4043350 | 0.83 | HTRA1 (0.35) | CTSKITGA4ITGB7HTRA1 | |
| SCHEMBL4044160 | 0.83 | CTSB (0.37) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |