SCHEMBL406254

SCHEMBL406254

CC(=O)C(C)(O)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.47
SSTR4 P31391 1/20 0.42
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
CASR P41180 1/20 0.40
CYP2C19 P33261 1/20 0.38
CYP19A1 P11511 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
POLB P06746 1/20 0.37
EPHX1 P07099 1/20 0.37
EPHX2 P34913 1/20 0.37
CYP3A4 P08684 1/20 0.36
APEX1 P27695 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
AR P10275 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2348384 0.85 TSHR (0.47) TSHRSSTR4HDAC3HDAC1HDAC2
SCHEMBL22939210 0.84 HTT (0.45) TSHRMEN1KMT2ASMN1; SMN2
SCHEMBL602699 0.82 TSHR (0.48) TSHRSSTR4HDAC3HDAC1HDAC2
SCHEMBL22938100 0.81 KDR (0.47) AR
SCHEMBL27932320 0.80 SMN1; SMN2 (0.46) TSHRSSTR4HDAC3HDAC1HDAC2
SCHEMBL11303263 0.78 KMT2A (0.58) TSHRCYP2C19CYP19A1MEN1KMT2A
SCHEMBL10600692 0.77 TSHR (0.56) TSHRSSTR4HDAC3HDAC1HDAC2
SCHEMBL1978775 0.75 TSHR (0.41) TSHRSSTR4HDAC3HDAC1HDAC2
SCHEMBL1627092 0.74 TSHR (0.48) TSHRSSTR4HDAC3HDAC1HDAC2
SCHEMBL1626481 0.74 AKR1C3 (0.51) TSHRSSTR4HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260140422-A1 Electro-Optic Polymer Devices Having High Performance Claddings, and Methods of Preparing the Same LIGHTWAVE LOGIC, INC. (US) 2026-05-21 US disclosed
US-20260071119-A1 Nonlinear Optical Chromophores Containing Furanyl Accepting Groups, and Methods of Making and Using the Same LIGHTWAVE LOGIC, INC. (US) 2026-03-12 US disclosed
US-12547041-B2 Electro-optic polymer devices having high performance claddings, and methods of preparing the same LIGHTWAVE LOGIC, INC. (US) 2026-02-10 US disclosed
US-12286438-B2 Nonlinear optical chromophores, nonlinear optical materials containing the same, and uses thereof in optical devices LIGHTWAVE LOGIC, INC. (US) 2025-04-29 US disclosed
US-20240336623-A1 NONLINEAR OPTICAL CHROMOPHORES, NONLINEAR OPTICAL MATERIALS CONTAINING THE SAME, AND USES THEREOF IN OPTICAL DEVICES LIGHTWAVE LOGIC, INC. (US) 2024-10-10 US disclosed
US-12043628-B2 Nonlinear optical chromophores, nonlinear optical materials containing the same, and uses thereof in optical devices LIGHTWAVE LOGIC, INC. (US) 2024-07-23 US disclosed
US-20240176202-A1 Electro-Optic Polymer Devices Having High Performance Claddings, and Methods of Preparing the Same LIGHTWAVE LOGIC, INC. (US) 2024-05-30 US disclosed
US-11927868-B2 Electro-optic polymer devices having high performance claddings, and methods of preparing the same LIGHTWAVE LOGIC, INC. (US) 2024-03-12 US disclosed
US-20230312600-A1 NONLINEAR OPTICAL CHROMOPHORES, NONLINEAR OPTICAL MATERIALS CONTAINING THE SAME, AND USES THEREOF IN OPTICAL DEVICES LIGHTWAVE LOGIC, INC. (US) 2023-10-05 US disclosed
US-20230251543-A1 Electro-Optic Polymer Devices Having High Performance Claddings, and Methods of Preparing the Same LIGHTWAVE LOGIC, INC. (US) 2023-08-10 US disclosed
US-11661428-B1 Nonlinear optical chromophores, nonlinear optical materials containing the same, and uses thereof in optical devices LIGHTWAVE LOGIC, INC. (US) 2023-05-30 US disclosed
US-11614670-B2 Electro-optic polymer devices having high performance claddings, and methods of preparing the same LIGHTWAVE LOGIC, INC. (US) 2023-03-28 US disclosed
US-20210032228-A1 ELECTRO-OPTIC POLYMER NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) 2021-02-04 US disclosed
US-20200183245-A1 ELECTRO-OPTIC POLYMER DEVICES HAVING HIGH PERFORMANCE CLADDINGS, AND METHODS OF PREPARING THE SAME LIGHTWAVE LOGIC, INC. (US) 2020-06-11 US disclosed
US-20200183245-A1 ELECTRO-OPTIC POLYMER DEVICES HAVING HIGH PERFORMANCE CLADDINGS, AND METHODS OF PREPARING THE SAME LIGHTWAVE LOGIC, INC. (US) 2020-06-11 US disclosed
WO-2019151318-A1 ELECTRO-OPTICAL POLYMER 国立研究開発法人情報通信研究機構 2019-08-08 WO disclosed
US-20120329865-A1 MOLECULES RELATED hERG ION CHANNELS AND THE USE THEREOF CORNING INCORPORATED 2012-12-27 US disclosed
EP-2519236-A2 MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF Corning Incorporated (US) 2012-11-07 EP disclosed
US-20120022116-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX CORNING INCORPORATED 2012-01-26 US disclosed
WO-2011081970-A2 MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF CORNING INCORPORATED (US) 2011-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12286438-B2 Nonlinear optical chromophores, nonlinear optical materials containing the same, and uses thereof in optical devices MB, CYBA, GNE TSHR 4029/4885SSTR4 3446/4885HDAC3 3379/4885
US-12043628-B2 Nonlinear optical chromophores, nonlinear optical materials containing the same, and uses thereof in optical devices MB, CYBA, GNE TSHR 4029/4885SSTR4 3446/4885HDAC3 3379/4885
US-20120022116-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX GPR35, GPR65, GPR68 TSHR 1910/4885SSTR4 1772/4885HDAC3 881/4885
US-20230312600-A1 NONLINEAR OPTICAL CHROMOPHORES, NONLINEAR OPTICAL MATERIALS CONTAINING THE SAME, AND USES THEREOF IN OPTICAL DEVICES MB, CYBA, GNE TSHR 4029/4885SSTR4 3446/4885HDAC3 3379/4885
US-20260071119-A1 Nonlinear Optical Chromophores Containing Furanyl Accepting Groups, and Methods of Making and Using the Same NCL, HCN2, B3GNT2 TSHR 3435/4885SSTR4 3028/4885HDAC3 1559/4885
US-12547041-B2 Electro-optic polymer devices having high performance claddings, and methods of preparing the same ELOC, ODC1, AOC1 TSHR 3710/4885SSTR4 4329/4885HDAC3 2811/4885
US-20240336623-A1 NONLINEAR OPTICAL CHROMOPHORES, NONLINEAR OPTICAL MATERIALS CONTAINING THE SAME, AND USES THEREOF IN OPTICAL DEVICES MB, CYBA, GNE TSHR 4029/4885SSTR4 3446/4885HDAC3 3379/4885
US-11661428-B1 Nonlinear optical chromophores, nonlinear optical materials containing the same, and uses thereof in optical devices MB, CYBA, GNE TSHR 4029/4885SSTR4 3446/4885HDAC3 3379/4885
US-20120329865-A1 MOLECULES RELATED hERG ION CHANNELS AND THE USE THEREOF KCNH2, KCNJ2, KCNH3 TSHR 726/4885SSTR4 687/4885HDAC3 233/4885
US-20210032228-A1 ELECTRO-OPTIC POLYMER TECR, AQP3, LAGE3 TSHR 1027/4885SSTR4 935/4885HDAC3 756/4885
US-20260140422-A1 Electro-Optic Polymer Devices Having High Performance Claddings, and Methods of Preparing the Same ELOC, EYA3, SDC2 TSHR 3700/4885SSTR4 3953/4885HDAC3 2737/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.