Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5470345 | 0.89 | RAB9A (0.58) | MAOAKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL18852011 | 0.82 | PIM1 (0.47) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL5323077 | 0.79 | ALDH1A1 (0.56) | MAOAKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL4078024 | 0.79 | MAOA (0.53) | MAOAKDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL18852012 | 0.79 | CSNK2B (0.51) | KDM4EALDH1A1PIM1CSNK2BCSNK2A2 | |
| SCHEMBL24026229 | 0.78 | KMT2A (0.49) | MAOAKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL1984213 | 0.78 | KMT2A (0.56) | MAOAKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL13377736 | 0.77 | ABCG2 (0.61) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL1905327 | 0.75 | KDM4E (0.62) | MAOAKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL14028590 | 0.73 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDNPC1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033645-A1 | Isoquinoline derivatives and methods of use thereof | Inotek Pharmaceuticals Corporation (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20070249653-A1 | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249653-A1 | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249653-A1 | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| US-7268143-B2 | Isoquinoline derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-09-11 | — | — | US | disclosed |
| US-7217709-B2 | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-05-15 | — | — | US | disclosed |
| US-7217709-B2 | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-05-15 | — | — | US | disclosed |
| US-20060019980-A1 | Methods for treating or preventing erectile dysfunction or urinary incontinence | INOTEK PHARMACEUTICAL, CORP. (US) | 2006-01-26 | — | — | US | disclosed |
| US-6956035-B2 | Isoquinoline derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2005-10-18 | — | — | US | disclosed |
| US-20050228007-A1 | Isoquinoline derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION | 2005-10-13 | — | — | US | disclosed |
| US-20050049270-A1 | Isoquinoline derivatives and methods of use thereof | JAGTAP PRAKASH (US) | 2005-03-03 | — | — | US | disclosed |
| US-20040229895-A1 | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION | 2004-11-18 | — | — | US | disclosed |
| US-20040039009-A1 | Isoquinoline derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228007-A1 | Isoquinoline derivatives and methods of use thereof | GLS, PINK1, PARK7 | MAOA 1092/4885KDM4E 3282/4885ALDH1A1 635/4885 |
| US-20060019980-A1 | Methods for treating or preventing erectile dysfunction or urinary incontinence | PDE3A, PDE3B, PDE5A | MAOA 48/4885KDM4E 1369/4885ALDH1A1 478/4885 |
| US-20040039009-A1 | Isoquinoline derivatives and methods of use thereof | CYP3A7, CYP3A5, ABCG2 | MAOA 485/4885KDM4E 1995/4885ALDH1A1 1165/4885 |
| US-20070249653-A1 | Tetracyclic benzamide derivatives and methods of use thereof | TBC1D5, TBC1D15, BAD | MAOA 1772/4885KDM4E 2163/4885ALDH1A1 585/4885 |
| US-20050049270-A1 | Isoquinoline derivatives and methods of use thereof | CYP3A7, CYP3A5, ABCG2 | MAOA 485/4885KDM4E 1995/4885ALDH1A1 1165/4885 |
| US-20040229895-A1 | Tetracyclic benzamide derivatives and methods of use thereof | TBC1D5, TBC1D15, BAD | MAOA 1772/4885KDM4E 2163/4885ALDH1A1 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.