Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27099161 | 0.88 | CHRNA7 (0.64) | L3MBTL1BAZ2BALOX15HSD17B10USP2 | |
| SCHEMBL12868041 | 0.86 | BAZ2B (0.56) | L3MBTL1BAZ2BALOX15HSD17B10USP2 | |
| Dehydrostobadine SCHEMBL29468212 | 0.84 | L3MBTL1 (0.97) | L3MBTL1BAZ2BALOX15HSD17B10USP2 | |
| Dehydrostobadine SCHEMBL167500 | 0.84 | L3MBTL1 (0.97) | L3MBTL1BAZ2BALOX15HSD17B10USP2 | |
| SCHEMBL2186097 | 0.82 | L3MBTL1 (0.70) | L3MBTL1BAZ2BALOX15HSD17B10USP2 | |
| SCHEMBL19252850 | 0.82 | L3MBTL1 (0.70) | L3MBTL1BAZ2BALOX15HSD17B10USP2 | |
| Dehydrostobadine SCHEMBL2837548 | 0.82 | L3MBTL1 (1.00) | L3MBTL1BAZ2BALOX15HSD17B10USP2 | |
| SCHEMBL3024458 | 0.82 | L3MBTL1 (0.70) | L3MBTL1ALOX15HSD17B10USP2CYP1A2 | |
| SCHEMBL13356240 | 0.82 | L3MBTL1 (0.70) | L3MBTL1ALOX15HSD17B10USP2CYP1A2 | |
| SCHEMBL167328 | 0.82 | L3MBTL1 (0.70) | L3MBTL1BAZ2BALOX15HSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420235-A1 | Methods and combination therapies for treating alzheimer's disease | Medivation Neurology, Inc. (US) | 2012-02-22 | — | — | EP | claimed |
| US-20100152108-A1 | METHODS AND COMBINATION THERAPIES FOR TREATING ALZHEIMER'S DISEASE | MEDIVATION NEUROLOGY, INC. (US) | 2010-06-17 | — | — | US | claimed |
| US-20100152225-A1 | HYDROGENATED PYRIDO [4,3-B] INDOLES SUCH AS DIMEBON FOR TREATING CANINE COGNITIVE DYSFUNCTION SYNDROME | MEDIVATION NEUROLOGY, INC. | 2010-06-17 | — | — | US | claimed |
| US-20100099700-A1 | HYDROGENATED PYRIDO (4,3-B) INDOLES FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) | MEDIVATION NEUROLOGY, INC. | 2010-04-22 | — | — | US | claimed |
| EP-2086538-A2 | COMBINATION THERAPIES FOR TREATING ALZHEIMER'S DISEASE USING I.A. DIMEBON AND DOLEPEZIL | Medivation Neurology, Inc. (US) | 2009-08-12 | — | — | EP | claimed |
| EP-2063892-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) | Medivation Neurology, Inc. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2009039420-A9 | METHODS AND COMPOSITIONS FOR TREATING NEURONAL DEATH MEDIATED OCULAR DISEASES | MEDIVATION NEUROLOGY INC (US) | 2009-05-07 | — | — | WO | claimed |
| WO-2009039420-A1 | METHODS AND COMPOSITIONS FOR TREATING NEURONAL DEATH MEDIATED OCULAR DISEASES | MEDIVATION NEUROLOGY, INC. (US) | 2009-03-26 | — | — | WO | claimed |
| US-20080234310-A1 | Methods and Compositions for Slowing Aging | MEDIVATION, INC. | 2008-09-25 | — | — | US | claimed |
| EP-1692131-A4 | METHODS AND COMPOSITIONS FOR SLOWING AGING | MEDIVATION INC (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2008051599-A2 | COMBINATION THERAPIES FOR TREATING ALZHEIMER'S DISEASE USING I. A. DIMEBON AND DOLEPEZIL | MEDIVATION NEUROLOGY, INC. (US) | 2008-05-02 | — | — | WO | claimed |
| WO-2008036410-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) | MEDIVATION NEUROLOGY, INC. (US) | 2008-03-27 | — | — | WO | claimed |
| US-20070225316-A1 | Methods and compositions for treating schizophrenia | MEDIVATION, INC. | 2007-09-27 | — | — | US | claimed |
| US-20070179174-A1 | Methods and compositions for slowing aging | MEDIVATION, INC. | 2007-08-02 | — | — | US | claimed |
| US-20070117835-A1 | Methods and compositions for treating Huntington's disease | MEDIVATION NEUROLOGY, INC. | 2007-05-24 | — | — | US | claimed |
| US-20070117834-A1 | Methods and compositions for treating Huntington's disease | MEDIVATION NEUROLOGY, INC. | 2007-05-24 | — | — | US | claimed |
| WO-2007041697-A2 | HYDROGENATED PYRIDO-INDOLE COMPOUNDS FOR THE TREATMENT OF HUNTINGTON ' S DISEASE | MEDIVATION, INC. (GB) | 2007-04-12 | — | — | WO | claimed |
| EP-1692131-A2 | METHODS AND COMPOSITIONS FOR SLOWING AGING | MEDIVATION, INC. (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005055951-A2 | METHODS AND COMPOSITIONS FOR SLOWING AGING | MEDIVATION, INC. (US) | 2005-06-23 | — | — | WO | claimed |
| EP-0876818-B1 | AGENT FOR TREATING NEURO-DEGENERATIVE DISORDERS | SELENA PHARMACEUTICALS INC (US) | 2002-12-18 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152108-A1 | METHODS AND COMBINATION THERAPIES FOR TREATING ALZHEIMER'S DISEASE | PSEN2, APP, PSEN1 | L3MBTL1 4152/4885BAZ2B 589/4885ALOX15 1029/4885 |
| US-20070225316-A1 | Methods and compositions for treating schizophrenia | SLC6A3, DBH, GRIN3B | L3MBTL1 4439/4885BAZ2B 957/4885ALOX15 828/4885 |
| US-20070179174-A1 | Methods and compositions for slowing aging | PRDX5, HMOX1, SHMT2 | L3MBTL1 1438/4885BAZ2B 1574/4885ALOX15 290/4885 |
| US-20070117835-A1 | Methods and compositions for treating Huntington's disease | HTT, HYPK, HTR6 | L3MBTL1 4123/4885BAZ2B 919/4885ALOX15 2543/4885 |
| US-20100152225-A1 | HYDROGENATED PYRIDO [4,3-B] INDOLES SUCH AS DIMEBON FOR TREATING CANINE COGNITIVE DYSFUNCTION SYNDROME | HPD, KYNU, IDO1 | L3MBTL1 3532/4885BAZ2B 648/4885ALOX15 1441/4885 |
| US-20100099700-A1 | HYDROGENATED PYRIDO (4,3-B) INDOLES FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) | HTT, NLN, SMN1; SMN2 | L3MBTL1 321/4885BAZ2B 507/4885ALOX15 71/4885 |
| US-20070117834-A1 | Methods and compositions for treating Huntington's disease | HTT, HYPK, HTR6 | L3MBTL1 4123/4885BAZ2B 919/4885ALOX15 2543/4885 |
| US-20080234310-A1 | Methods and Compositions for Slowing Aging | PRDX5, HMOX1, SHMT2 | L3MBTL1 1438/4885BAZ2B 1574/4885ALOX15 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.