Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 10/20 | 0.61 |
| ▸ | HTR3A | P46098 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.61 |
| ▸ | HTR3B | O95264 | 2/20 | 0.61 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.61 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MPO | P05164 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247499 | 0.84 | GAA (0.68) | HTR4HTR3ACYP1A2CYP2D6HTR3E | |
| SCHEMBL9153713 | 0.84 | HTR4 (0.41) | HTR4HTR3ACYP1A2CYP2D6HTR3E | |
| SCHEMBL9152344 | 0.83 | HTR4 (0.43) | HTR4HTR3ACYP1A2CYP2D6HTR3E | |
| Hydrochloric Acid SCHEMBL4158811 | 0.81 | RAB9A (0.45) | HTR4HTR3ACYP1A2CYP2D6HTR3E | |
| SCHEMBL10371973 | 0.80 | ALDH1A1 (0.41) | HTR4HTR3ACYP1A2CYP2D6HTR3E | |
| SCHEMBL11408654 | 0.79 | ALDH1A1 (0.45) | HTR4HTR3ACYP1A2CYP2D6HTR3E | |
| SCHEMBL5925585 | 0.79 | GAA (0.60) | HTR4HTR3ACYP1A2CYP2D6HTR3E | |
| SCHEMBL7751850 | 0.79 | GAA (0.71) | HTR4HTR3ACYP1A2CYP2D6HTR3E | |
| SCHEMBL11395774 | 0.78 | ALDH1A1 (0.41) | HTR4HTR3ACYP1A2CYP2D6HTR3E | |
| SCHEMBL3102868 | 0.78 | HTR4 (0.70) | HTR4HTR3ACYP1A2CYP2D6HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241797-B2 | Method of increasing milk production | UNIVERSITY OF CINCINNATI (US) | 2007-07-10 | — | — | US | claimed |
| US-20030139420-A1 | Method of increasing milk production | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-07-24 | — | — | US | claimed |
| EP-0652767-B1 | TREATMENT OF HUMAN LACTATION FAILURE | PHARMACIA & UPJOHN AB (SE) | 1999-09-15 | — | — | EP | claimed |
| EP-0652767-A1 | TREATMENT OF HUMAN LACTATION FAILURE | Pharmacia AB (SE) | 1995-05-17 | — | — | EP | claimed |
| WO-1992002245-A1 | TREATMENT OF HUMAN LACTATION FAILURE | KABI PHARMACIA AB (SE) | 1992-02-20 | — | — | WO | claimed |
| JP-4208259-A | — | — | None | — | — | JP | disclosed |
| CN-117686642-A | Ion chromatography detection method for residual reagent dimethyl sulfate in medicine | 绪必迪药业(沧州)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-114652690-B | New metoclopramide preparation for intestinal obstruction and process thereof | 山东新时代药业有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-114652690-A | New metoclopramide preparation for intestinal obstruction and process thereof | 山东新时代药业有限公司 | 2022-06-24 | — | — | CN | disclosed |
| US-20090209615-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-20 | — | — | US | disclosed |
| US-20090203940-A1 | Method for preparing 4-[2-(dimethylamino)ethoxy]benzylamine as itopride-hydrocloride salt mediate | IL-YANG PHARM. CO., LTD. (KR) | 2009-08-13 | — | — | US | disclosed |
| US-20090118303-A1 | SEROTONIN 5-HT3 RECEPTOR AGONIST | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2009-05-07 | — | — | US | disclosed |
| US-4870074-A | Substituted benzamide derivatives, for enhancing gastrointestinal motility | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0306827-A1 | Amide compounds, process for preparing the same, and composition for activating gastric motor function containing the same | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1989-03-15 | — | — | EP | disclosed |
| EP-0305008-A2 | Tumor or cancer cell killing therapy and agents useful therefor | OXI-GENE, INC. (US) | 1989-03-01 | — | — | EP | disclosed |
| EP-0243959-A1 | Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |
| EP-0234872-A1 | Carboxamides useful as antiemetic or antipsychotic agents | Erbamont Inc. (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0147044-A2 | Benzofurancarboxamides, process for their preparation and pharmaceutical preparations containing them | ADRIA LABORATORIES INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| US-4109005-A | METHOD OF INCREASING RATE OF GASTRIC EMPTYING WITH PYRROLIDINYLBENZAMIDES | A. H. ROBINS COMPANY, INC. (US) | 1978-08-22 | — | — | US | disclosed |
| US-4041032-A | ANTIEMATICS, GASTRIC MOTILITY STIMULANTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) | 1977-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209615-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | MMP9, MMP10, MMP17 | HTR4 2993/4885HTR3A 1831/4885CYP1A2 1149/4885 |
| US-20090203940-A1 | Method for preparing 4-[2-(dimethylamino)ethoxy]benzylamine as itopride-hydrocloride salt mediate | KCNN1, HCN4, KCNN2 | HTR4 201/4885HTR3A 430/4885CYP1A2 132/4885 |
| US-20090118303-A1 | SEROTONIN 5-HT3 RECEPTOR AGONIST | HTR3A, HTR7, HTR1A | HTR4 7/4885HTR3A 1/4885CYP1A2 1262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.