SCHEMBL409751

SCHEMBL409751

CC1(C)[CH]Cc2ccccc2O1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
SIGMAR1 Q99720 2/20 0.34
CYP2D6 P10635 2/20 0.33
TSHR P16473 2/20 0.33
CYP2C19 P33261 2/20 0.33
CYP1A2 P05177 1/20 0.33
PKM P14618 1/20 0.33
NFKB1 P19838 1/20 0.33
THPO P40225 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NISCH Q9Y2I1 1/20 0.33
MEN1 O00255 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
KMT2A Q03164 1/20 0.33
NPSR1 Q6W5P4 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7784011 0.72 MAOA (0.33) MAOAMAOBCYP2D6TSHRCYP2C19
SCHEMBL1441712 0.71 PKM (0.41) MAOAMAOBCYP2D6TSHRCYP2C19
SCHEMBL2023897 0.70 MAOA (0.42) MAOAMAOBSIGMAR1CYP2D6TSHR
SCHEMBL2925890 0.70 PPIB (0.41) SIGMAR1SMN1; SMN2HTR2ADRD2GAA
SCHEMBL5525165 0.70 MAOA (0.38) MAOAMAOBNPSR1OXTRABCG2
SCHEMBL30005029 0.69 SIGMAR1 (0.44) MAOAMAOBSIGMAR1CYP2D6TSHR
SCHEMBL23811463 0.68 CYP2D6 (0.39) MAOAMAOBCYP2D6TSHRCYP2C19
SCHEMBL10382409 0.68 CYP2C19 (0.39) MAOAMAOBCYP2D6TSHRCYP2C19
SCHEMBL4854732 0.68 SIGMAR1 (0.43) MAOAMAOBSIGMAR1CYP2D6TSHR
SCHEMBL888447 0.68 TSHR (0.39) MAOAMAOBCYP2D6TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022026823-A1 CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF CHAN ZUCKERBERG BIOHUB, INC. (US) 2022-02-03 WO claimed
US-20240115557-A1 INHIBITORS OF RNA-GUIDED NUCLEASES AND USES THEREOF THE BROAD INSTITUTE, INC. 2024-04-11 US disclosed
US-11787795-B2 Inhibitors of RNA guided nucleases and uses thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-10-17 US disclosed
US-20210177832-A1 INHIBITORS OF RNA-GUIDED NUCLEASE TARGET BINDING AND USES THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-06-17 US disclosed
US-20190263807-A1 INHIBITORS OF RNA GUIDED NUCLEASES AND USES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2019-08-29 US disclosed
US-20190134056-A1 K-RAS MUTATIONS AND ANTAGONISTS THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOG (US) 2019-05-09 US disclosed
US-10183011-B2 Anti-depression compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-01-22 US disclosed
US-10172827-B2 Pro-neurogenic compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-01-08 US disclosed
US-20180318255-A1 Pro-Neurogenic Compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2018-11-08 US disclosed
EP-2385829-B1 PRO-NEUROGENIC COMPOUNDS UNIV TEXAS (US) 2018-08-01 EP disclosed
WO-2010081115-A1 PRO-NEUROGENIC COMPOUNDS UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) 2010-07-15 WO disclosed
US-20100029648-A1 11-Beta HSD1 Inhibitors XIANG JASON SHAOYUN 2010-02-04 US disclosed
US-7632838-B2 11-beta HSD1 inhibitors WYETH (US) 2009-12-15 US disclosed
EP-1981848-A2 11-BETA HSD1 INHIBITORS Wyeth (US) 2008-10-22 EP disclosed
US-20070219198-A1 11-Beta HSD 1 inhibitors WYETH (US) 2007-09-20 US disclosed
WO-2007092435-A2 11-BETA HSD1 INHIBITORS WYETH (US) 2007-08-16 WO disclosed
US-4734121-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1988-03-29 US disclosed
US-4668275-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1987-05-26 US disclosed
EP-0107156-B1 CYCLOHEXANE-1,3-DIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE CONTROL OF UNDESIRABLE PLANT GROWTH BASF Aktiengesellschaft (DE) 1986-12-30 EP disclosed
EP-0107156-A1 Cyclohexane-1,3-dione derivatives, process for their preparation and their use in the control of undesirable plant growth BASF Aktiengesellschaft (DE) 1984-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210177832-A1 INHIBITORS OF RNA-GUIDED NUCLEASE TARGET BINDING AND USES THEREOF RNASEH1, RNASEL, RNASE1 MAOA 1866/4885MAOB 1325/4885SIGMAR1 4433/4885
US-10172827-B2 Pro-neurogenic compounds DCX, GAP43, BDNF MAOA 2000/4885MAOB 1329/4885SIGMAR1 1003/4885
US-20100029648-A1 11-Beta HSD1 Inhibitors HSD11B1, HSD3B1, HSD11B2 MAOA 3028/4885MAOB 2621/4885SIGMAR1 3376/4885
US-20190263807-A1 INHIBITORS OF RNA GUIDED NUCLEASES AND USES THEREOF RNASE1, RNASEH1, RNASEL MAOA 1932/4885MAOB 1452/4885SIGMAR1 4220/4885
US-20180318255-A1 Pro-Neurogenic Compounds BDNF, GAP43, DCX MAOA 1758/4885MAOB 1083/4885SIGMAR1 2231/4885
US-20240115557-A1 INHIBITORS OF RNA-GUIDED NUCLEASES AND USES THEREOF ZFR, ENDOD1, FEN1 MAOA 4127/4885MAOB 3941/4885SIGMAR1 4272/4885
US-10183011-B2 Anti-depression compounds BDNF, DCX, GAP43 MAOA 1736/4885MAOB 1109/4885SIGMAR1 2283/4885
US-20190134056-A1 K-RAS MUTATIONS AND ANTAGONISTS KRAS, NRAS, HRAS MAOA 4754/4885MAOB 4703/4885SIGMAR1 4020/4885
US-11787795-B2 Inhibitors of RNA guided nucleases and uses thereof RNASE1, RNASEH1, RNASEL MAOA 1932/4885MAOB 1452/4885SIGMAR1 4220/4885
US-20070219198-A1 11-Beta HSD 1 inhibitors HSD11B1, HSD11B2, HSD3B1 MAOA 1996/4885MAOB 1849/4885SIGMAR1 2861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.