Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HEXA | P06865 | 1/20 | 0.45 |
| ▸ | HEXB | P07686 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31208305 | 1.00 | GAA (0.62) | GAAALDH1A1RECQLCYP1A2TDP1 | |
| SCHEMBL20125239 | 0.86 | GAA (0.59) | GAAALDH1A1RECQLCYP1A2TDP1 | |
| SCHEMBL3485810 | 0.83 | GAA (0.59) | GAAALDH1A1RECQLCYP1A2TDP1 | |
| SCHEMBL22326350 | 0.82 | GAA (0.88) | GAAALDH1A1RECQLCYP1A2TDP1 | |
| SCHEMBL4917285 | 0.82 | GAA (0.54) | GAAALDH1A1RECQLCYP1A2TDP1 | |
| SCHEMBL1671882 | 0.82 | GAA (0.54) | GAAALDH1A1RECQLCYP1A2TDP1 | |
| Hydrochloric Acid SCHEMBL3485772 | 0.81 | GAA (0.57) | GAAALDH1A1RECQLCYP1A2TDP1 | |
| SCHEMBL10601228 | 0.81 | MAOB (0.62) | GAAALDH1A1 | |
| SCHEMBL2641485 | 0.80 | HTR1B (0.43) | GAAALDH1A1RECQLCYP1A2TDP1 | |
| SCHEMBL6625137 | 0.79 | GAA (0.69) | GAAALDH1A1RECQLCYP1A2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240409533-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-12-12 | — | — | US | disclosed |
| US-12071433-B2 | HMOX1 inducers | Astellas Engineered Small Molecules US, Incorporated (US) | 2024-08-27 | — | — | US | disclosed |
| US-20240051952-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-02-15 | — | — | US | disclosed |
| EP-3722291-B1 | INDOLINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF FIBROTIC DISEASES | RESPIVERT LTD (GB) | 2023-07-19 | — | — | EP | disclosed |
| EP-3722291-B1 | INDOLINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF FIBROTIC DISEASES | RESPIVERT LTD (GB) | 2023-07-19 | — | — | EP | disclosed |
| US-20220177460-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2022-06-09 | — | — | US | disclosed |
| US-20220177460-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2022-06-09 | — | — | US | disclosed |
| EP-3952990-A1 | HMOX1 INDUCERS | Mitobridge, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| CN-113874074-A | HMOX1 inducers | 米托布里奇公司 | 2021-12-31 | — | — | CN | disclosed |
| US-11046672-B2 | Indolinones compounds and their use in the treatment of fibrotic diseases | RESPIVERT LIMITED (GB) | 2021-06-29 | — | — | US | disclosed |
| US-20140179691-A1 | NOVEL OXAZOLIDINONE DERIVATIVE AND MEDICAL COMPOSITION CONTAINING SAME | LEGOCHEM BIOSCIENCES, INC. (KR) | 2014-06-26 | — | — | US | disclosed |
| US-8637667-B2 | Method for preparing (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives | LEGOCHEM BIOSCIENCE LTD. (KR) | 2014-01-28 | — | — | US | disclosed |
| US-20120302516-A1 | NANOPARTICLES FOR DRUG DELIVERY | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2012-11-29 | — | — | US | disclosed |
| US-20120108808-A1 | METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES | LEGOCHEM BIOSCIENCE LTD. (KR) | 2012-05-03 | — | — | US | disclosed |
| US-20050203144-A1 | Bicyclo[3.1.0]hexane containing oxazolidinone antibiotics and derivatives thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2005-09-15 | — | — | US | disclosed |
| EP-1385834-B1 | BICYCLO[3,1,0]HEXANE CONTAINING OXAZOLIDINONE ANTIBIOTIC AND DERIVATIVES THEREOF | MERCK & CO INC (US) | 2005-09-14 | — | — | EP | disclosed |
| US-6897230-B2 | Bicyclo[3/1/0] hexane containing oxazolidinone antibiotics and derivatives thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2005-05-24 | — | — | US | disclosed |
| EP-1385834-A1 | BICYCLO[3,1,0]HEXANE CONTAINING OXAZOLIDINONE ANTIBIOTIC AND DERIVATIVES THEREOF | Merck & Co., Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| US-20030125367-A1 | Bicyclo[3,1,0]hexane containing oxazolidinone antibioytics and derivatives thereof | KYORIN PHARMACEUTICAL CO., LTD. | 2003-07-03 | — | — | US | disclosed |
| WO-2003027083-A1 | BICYCLO[3,1,0]HEXANE CONTAINING OXAZOLIDINONE ANTIBIOTIC AND DERIVATIVES THEREOF | MERCK & CO., INC. (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179691-A1 | NOVEL OXAZOLIDINONE DERIVATIVE AND MEDICAL COMPOSITION CONTAINING SAME | OXA1L, PAM, ABCC1 | GAA 1666/4885ALDH1A1 1667/4885RECQL 89/4885 |
| US-20030125367-A1 | Bicyclo[3,1,0]hexane containing oxazolidinone antibioytics and derivatives thereof | NR4A1, NR0B1, NR1D1 | GAA 4035/4885ALDH1A1 708/4885RECQL 1435/4885 |
| US-20050203144-A1 | Bicyclo[3.1.0]hexane containing oxazolidinone antibiotics and derivatives thereof | NR0B1, NR4A1, VDR | GAA 3705/4885ALDH1A1 741/4885RECQL 919/4885 |
| US-20240409533-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, HMBS | GAA 2202/4885ALDH1A1 332/4885RECQL 3936/4885 |
| US-12071433-B2 | HMOX1 inducers | HMOX1, HMOX2, HMBS | GAA 2123/4885ALDH1A1 223/4885RECQL 3568/4885 |
| US-20240051952-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, QSOX1 | GAA 1965/4885ALDH1A1 266/4885RECQL 3384/4885 |
| US-20220177460-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, HMBS | GAA 2123/4885ALDH1A1 223/4885RECQL 3568/4885 |
| US-11046672-B2 | Indolinones compounds and their use in the treatment of fibrotic diseases | IDO1, INMT, IDO2 | GAA 3846/4885ALDH1A1 373/4885RECQL 1056/4885 |
| US-20120108808-A1 | METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES | F2, F11, F5 | GAA 2082/4885ALDH1A1 1161/4885RECQL 3836/4885 |
| US-20120302516-A1 | NANOPARTICLES FOR DRUG DELIVERY | HIF1AN, CD47, EGLN2 | GAA 2209/4885ALDH1A1 757/4885RECQL 3493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.