SCHEMBL4251283

SCHEMBL4251283

Nc1c(C(=O)O)cccc1-c1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 2/20 0.46
RIPK1 Q13546 1/20 0.43
ACMSD Q8TDX5 1/20 0.43
KDR P35968 2/20 0.42
FLT3 P36888 2/20 0.42
KIT P10721 1/20 0.42
MPL P40238 2/20 0.41
G6PD P11413 1/20 0.41
CASP7 P55210 1/20 0.41
CASP6 P55212 1/20 0.41
FABP4 P15090 5/20 0.40
FABP3 P05413 1/20 0.40
ALOX5AP P20292 1/20 0.40
FEN1 P39748 1/20 0.40
CFTR P13569 1/20 0.40
RAB9A P51151 1/20 0.39
CSF1R P07333 1/20 0.39
RET P07949 1/20 0.39
FGFR1 P11362 1/20 0.39
FLT1 P17948 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9501440 0.82 KMO (0.43) KMORIPK1ACMSDKDRFLT3
SCHEMBL31583298 0.79 BCAT2 (0.51) KMORIPK1MPLALOX5APFEN1
SCHEMBL10588475 0.79 RORB (0.56) KMO
SCHEMBL17744770 0.77 G6PD (0.55) KMOACMSDG6PDCASP7CASP6
SCHEMBL17744826 0.77 G6PD (0.59) G6PDCASP7CASP6FABP4FABP3
SCHEMBL1358529 0.77 ALDH1A1 (0.49) KMOG6PDCASP7CASP6FABP4
SCHEMBL16608991 0.75 KMO (0.54) KMOMPL
SCHEMBL9501436 0.74 KMO (0.43) KMOKDRFLT3KITFABP4
SCHEMBL27731061 0.74 KMO (0.44) KMORIPK1MPLAURKB
SCHEMBL158167 0.74 G6PD (0.55) G6PDCASP7CASP6FABP4CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090131527-A1 NOVEL ANTHRANILIC ACID DERIVATIVES AND CHLORIDE CHANNEL BLOCKING AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2009-05-21 US claimed
US-20090131527-A1 NOVEL ANTHRANILIC ACID DERIVATIVES AND CHLORIDE CHANNEL BLOCKING AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2009-05-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090131527-A1 NOVEL ANTHRANILIC ACID DERIVATIVES AND CHLORIDE CHANNEL BLOCKING AGENT CONTAINING THE SAME CLIC1, ASIC1, CLIC4 KMO 729/4885RIPK1 3308/4885ACMSD 515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.