Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | P2RY10 | O00398 | 4/20 | 0.39 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | DGKA | P23743 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264512 | 0.92 | FAAH (0.51) | FAAHEPHX2ALDH1A1MAPTTHRB | |
| Cadaverine Tartrate SCHEMBL5987469 | 0.88 | FAAH (0.45) | FAAHEPHX2P2RY10GPR34ALDH1A1 | |
| Cadaverine Tartrate SCHEMBL5986724 | 0.80 | THRA (0.44) | FAAHALDH1A1MAPTTHRBDGKA | |
| SCHEMBL2323553 | 0.79 | SIGMAR1 (0.51) | ALDH1A1MAPTNAAASIGMAR1 | |
| SCHEMBL3669028 | 0.79 | SIGMAR1 (0.51) | ALDH1A1MAPTNAAASIGMAR1 | |
| SCHEMBL5990174 | 0.78 | FAAH (0.52) | FAAHEPHX2ALDH1A1MAPTTHRB | |
| SCHEMBL27907907 | 0.78 | FAAH (0.48) | FAAHEPHX2MAPT | |
| SCHEMBL5724530 | 0.78 | SIGMAR1 (0.50) | ALDH1A1NAAASIGMAR1 | |
| SCHEMBL163676 | 0.76 | FAAH (0.51) | FAAHEPHX2MAPT | |
| SCHEMBL163678 | 0.76 | FAAH (0.51) | FAAHEPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987263-B2 | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-03-24 | — | — | US | claimed |
| EP-2117301-A1 | USE OF LONG-CHAIN ALCOHOL DERIVATIVES FOR THE TREATMENT OF ALOPECIA AREATA | Yeda Research And Development Co. Ltd. At The Weizmann Institute of Science (IL) | 2009-11-18 | — | — | EP | claimed |
| US-20080221115-A1 | Use of long-chain alcohol derivatives for the treatment of alopecia areata | YEDA RESEARCH AND DEVELOPMENT CO. (IL) | 2008-09-11 | — | — | US | claimed |
| WO-2008106091-A1 | USE OF LONG-CHAIN ALCOHOL DERIVATIVES FOR THE TREATMENT OF ALOPECIA AREATA | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-09-04 | — | — | WO | claimed |
| US-20060173053-A1 | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2006-08-03 | — | — | US | claimed |
| EP-1551495-A2 | BASIC ESTERS OF FATTY ALCOHOLS AND THEIR USE AS ANTI-INFLAMMATORY OR IMMUNOMODULATORY AGENTS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2005-07-13 | — | — | EP | claimed |
| WO-2004032824-A2 | BASIC ESTERS OF FATTY ALCOHOLS AND THEIR USE AS ANTI-INFLAMMATORY OR IMMUNOMODULATORY AGENTS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2004-04-22 | — | — | WO | claimed |
| US-8987263-B2 | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-03-24 | — | — | US | disclosed |
| EP-2117301-A1 | USE OF LONG-CHAIN ALCOHOL DERIVATIVES FOR THE TREATMENT OF ALOPECIA AREATA | Yeda Research And Development Co. Ltd. At The Weizmann Institute of Science (IL) | 2009-11-18 | — | — | EP | disclosed |
| US-20080221115-A1 | Use of long-chain alcohol derivatives for the treatment of alopecia areata | YEDA RESEARCH AND DEVELOPMENT CO. (IL) | 2008-09-11 | — | — | US | disclosed |
| WO-2008106091-A1 | USE OF LONG-CHAIN ALCOHOL DERIVATIVES FOR THE TREATMENT OF ALOPECIA AREATA | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-09-04 | — | — | WO | disclosed |
| US-20060173053-A1 | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2006-08-03 | — | — | US | disclosed |
| EP-1551495-A2 | BASIC ESTERS OF FATTY ALCOHOLS AND THEIR USE AS ANTI-INFLAMMATORY OR IMMUNOMODULATORY AGENTS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004032824-A2 | BASIC ESTERS OF FATTY ALCOHOLS AND THEIR USE AS ANTI-INFLAMMATORY OR IMMUNOMODULATORY AGENTS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2004-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221115-A1 | Use of long-chain alcohol derivatives for the treatment of alopecia areata | SLC38A7, CCR8, ADH1A | FAAH 646/4885EPHX2 3591/4885P2RY10 4406/4885 |
| US-20060173053-A1 | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents | ALOX12, ALOX15, ALOX15B | FAAH 117/4885EPHX2 561/4885P2RY10 2481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.