Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenobarbital. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 6/20 | 0.50 |
| ▸ | MMP9 | P14780 | 6/20 | 0.50 |
| ▸ | MMP3 | P08254 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenobarbital SCHEMBL5712725 | 0.80 | KMT2A (0.50) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL11515939 | 0.76 | KMT2A (0.50) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL27833760 | 0.76 | MMP2 (0.75) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL28099657 | 0.75 | MMP2 (0.80) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL2592325 | 0.75 | MMP2 (0.80) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL16583 | 0.75 | MMP2 (0.80) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL18825042 | 0.75 | MMP2 (0.80) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL6807467 | 0.74 | MMP2 (0.77) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL1322895 | 0.74 | MMP2 (0.77) | KMT2ATSHRMEN1CYP1A2POLB | |
| Phenobarbital SCHEMBL2120028 | 0.74 | MMP2 (0.77) | KMT2ATSHRMEN1CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11878076-B2 | Lyophilized compositions of phenobarbital sodium salt | Nivagen Pharmaceuticals, Inc. (US) | 2024-01-23 | — | — | US | disclosed |
| US-20230157959-A1 | Lyophilized Compositions of Phenobarbital Sodium Salt | Nivagen Pharmaceuticals, Inc. (US) | 2023-05-25 | — | — | US | disclosed |
| US-20220354794-A1 | Lyophilized Compositions of Phenobarbital Sodium Salt | Nivagen Pharmaceuticals, Inc. (US) | 2022-11-10 | — | — | US | disclosed |
| US-11406598-B2 | Lyophilized compositions of phenobarbital sodium salt | Nivagen Pharmaceuticals, Inc. (US) | 2022-08-09 | — | — | US | disclosed |
| US-20210085608-A1 | Lyophilized Compositions of Phenobarbital Sodium Salt | Nivagen Pharmaceuticals, Inc. (US) | 2021-03-25 | — | — | US | disclosed |
| CN-112007172-A | Establishment and application of rodent tumor model for evaluating drug effect of anti-cancer drug | 中美冠科生物技术（太仓）有限公司 | 2020-12-01 | — | — | CN | disclosed |
| EP-3271722-B1 | METHODS TO DETECT NON-GENOTOXIC CARCINOGENS USING FLATWORMS | UNIV GENT (BE) | 2019-05-08 | — | — | EP | disclosed |
| US-10197556-B2 | Methods to detect non-genotoxic carcinogens using flatworms | UNIVERSITEIT GENT (BE) | 2019-02-05 | — | — | US | disclosed |
| US-20180059095-A1 | METHODS TO DETECT NON-GENOTOXIC CARCINOGENS USING FLATWORMS | UNIVERSITEIT GENT (BE) | 2018-03-01 | — | — | US | disclosed |
| EP-3271722-A1 | METHODS TO DETECT NON-GENOTOXIC CARCINOGENS USING FLATWORMS | Universiteit Gent (BE) | 2018-01-24 | — | — | EP | disclosed |
| WO-2016146620-A1 | METHODS TO DETECT NON-GENOTOXIC CARCINOGENS USING FLATWORMS | UNIVERSITEIT GENT (BE) | 2016-09-22 | — | — | WO | disclosed |
| US-20150031572-A1 | MEANS AND METHODS FOR ASSESSING NEURONAL TOXICITY | BASF SE (DE) | 2015-01-29 | — | — | US | disclosed |
| EP-2706123-A1 | In vitro method for determining genotoxic and non-genotoxic carcinogenicity of a compound. | Rijksinstituut Voor Volksgezondheid En Milieu (NL) | 2014-03-12 | — | — | EP | disclosed |
| EP-2021502-A1 | NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY | Oy Jurilab Ltd (FI) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007128884-A1 | NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY | OY JURILAB LTD (FI) | 2007-11-15 | — | — | WO | disclosed |